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57  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ALK_HUMAN (Q9UM73)

Summary

This is the summary of UniProt entry ALK_HUMAN (Q9UM73).

Description: ALK tyrosine kinase receptor EC=2.7.10.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1620 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 20
low_complexity n/a 5 13
disorder n/a 24 42
disorder n/a 78 79
low_complexity n/a 90 101
low_complexity n/a 95 106
disorder n/a 113 114
disorder n/a 201 202
disorder n/a 227 233
Pfam MAM 266 426
disorder n/a 299 310
disorder n/a 387 390
Pfam MAM 480 635
disorder n/a 649 652
disorder n/a 655 672
disorder n/a 696 702
Pfam Gly_rich 726 987
low_complexity n/a 737 747
low_complexity n/a 796 808
disorder n/a 812 814
low_complexity n/a 815 822
low_complexity n/a 840 850
disorder n/a 851 856
disorder n/a 860 865
low_complexity n/a 860 874
disorder n/a 867 869
low_complexity n/a 867 881
disorder n/a 901 903
disorder n/a 907 909
low_complexity n/a 918 939
disorder n/a 938 946
disorder n/a 948 952
low_complexity n/a 1032 1052
transmembrane n/a 1035 1059
Pfam PK_Tyr_Ser-Thr 1116 1383
disorder n/a 1341 1342
disorder n/a 1344 1346
disorder n/a 1397 1399
disorder n/a 1404 1560
low_complexity n/a 1404 1418
low_complexity n/a 1431 1448
disorder n/a 1590 1620

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UM73. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ
50
51
RKSLAVDFVV PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR
100
101
LLGPAPGVSW TAGSPAPAEA RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI
150
151
LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ GEGRLRIRLM PEKKASEVGR
200
201
EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY FTWNLTWIMK
250
251
DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ
300
301
MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS
350
351
VHRHLQPSGR YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF
400
401
RVALEYISSG NRSLSAVDFF ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ
450
451
LGQACDFHQD CAQGEDESQM CRKLPVGFYC NFEDGFCGWT QGTLSPHTPQ
500
501
WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP APIKSSPCEL
550
551
RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL
600
601
LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP
650
651
KSRNLFERNP NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ
700
701
CNNAYQNSNL SVEVGSEGPL KGIQIWKVPA TDTYSISGYG AAGGKGGKNT
750
751
MMRSHGVSVL GIFNLEKDDM LYILVGQQGE DACPSTNQLI QKVCIGENNV
800
801
IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII AAGGGGRAYG
850
851
AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA
900
901
TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM
950
951
DGEDGVSFIS PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE
1000
1001
SHKVICFCDH GTVLAEDGVS CIVSPTPEPH LPLSLILSVV TSALVAALVL
1050
1051
AFSGIMIVYR RKHQELQAMQ MELQSPEYKL SKLRTSTIMT DYNPNYCFAG
1100
1101
KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN DPSPLQVAVK
1150
1151
TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA
1200
1201
GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI
1250
1251
AARNCLLTCP GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA
1300
1301
FMEGIFTSKT DTWSFGVLLW EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP
1350
1351
PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL ERIEYCTQDP DVINTALPIE
1400
1401
YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA PPPLPTTSSG
1450
1451
KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT
1500
1501
SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL
1550
1551
PGASLLLEPS SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG
1600
1601
AGHYEDTILK SKNSMNQPGP                                 
1620
 

Show the unformatted sequence.

Checksums:
CRC64:0733D6C4FD212F41
MD5:638c4a64d52d6951aeba1a615d93068f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PK_Tyr_Ser-Thr 1116 - 1383 2XB7 A 1116 - 1383 Jmol OpenAstexViewer
2XBA A 1116 - 1383 Jmol OpenAstexViewer
2XP2 A 1116 - 1383 Jmol OpenAstexViewer
2YFX A 1116 - 1383 Jmol OpenAstexViewer
2YHV A 1116 - 1383 Jmol OpenAstexViewer
2YJR A 1116 - 1383 Jmol OpenAstexViewer
2YJS A 1116 - 1383 Jmol OpenAstexViewer
3AOX A 1116 - 1383 Jmol OpenAstexViewer
3L9P A 1116 - 1383 Jmol OpenAstexViewer
3LCS A 1116 - 1383 Jmol OpenAstexViewer
3LCT A 1116 - 1383 Jmol OpenAstexViewer
4ANL A 1116 - 1383 Jmol OpenAstexViewer
4ANQ A 1116 - 1383 Jmol OpenAstexViewer
4ANS A 1116 - 1383 Jmol OpenAstexViewer
4CCB A 1116 - 1383 Jmol OpenAstexViewer
4CCU A 1116 - 1383 Jmol OpenAstexViewer
4CD0 A 1116 - 1383 Jmol OpenAstexViewer
4CLI A 1116 - 1383 Jmol OpenAstexViewer
4CLJ A 1116 - 1383 Jmol OpenAstexViewer
4CMO A 1116 - 1383 Jmol OpenAstexViewer
4CMT A 1116 - 1383 Jmol OpenAstexViewer
4CMU A 1116 - 1383 Jmol OpenAstexViewer
4CNH A 1116 - 1383 Jmol OpenAstexViewer
B 1116 - 1383 Jmol OpenAstexViewer
4CTB A 1116 - 1383 Jmol OpenAstexViewer
4CTC A 1116 - 1383 Jmol OpenAstexViewer
4DCE A 1116 - 1383 Jmol OpenAstexViewer
B 1116 - 1383 Jmol OpenAstexViewer
4FNW A 1116 - 1383 Jmol OpenAstexViewer
4FNX A 1116 - 1383 Jmol OpenAstexViewer
4FNY A 1116 - 1383 Jmol OpenAstexViewer
4FNZ A 1116 - 1383 Jmol OpenAstexViewer
4FOB A 1116 - 1383 Jmol OpenAstexViewer
4FOC A 1116 - 1383 Jmol OpenAstexViewer
4FOD A 1116 - 1383 Jmol OpenAstexViewer
4JOA A 1116 - 1383 Jmol OpenAstexViewer
4MKC A 1116 - 1383 Jmol OpenAstexViewer
4TT7 A 1116 - 1383 Jmol OpenAstexViewer
4Z55 A 1116 - 1383 Jmol OpenAstexViewer
5A9U A 1116 - 1383 Jmol OpenAstexViewer
5AA8 A 1116 - 1383 Jmol OpenAstexViewer
5AA9 A 1116 - 1383 Jmol OpenAstexViewer
5AAA A 1116 - 1383 Jmol OpenAstexViewer
5AAB A 1116 - 1383 Jmol OpenAstexViewer
5AAC A 1116 - 1383 Jmol OpenAstexViewer
5FTO A 1116 - 1383 Jmol OpenAstexViewer
5FTQ A 1116 - 1383 Jmol OpenAstexViewer
5IMX A 1116 - 1383 Jmol OpenAstexViewer
5IUG A 1116 - 1383 Jmol OpenAstexViewer
5IUH A 1116 - 1383 Jmol OpenAstexViewer
5IUI A 1116 - 1383 Jmol OpenAstexViewer
5KZ0 A 1116 - 1383 Jmol OpenAstexViewer
6CDT A 1116 - 1383 Jmol OpenAstexViewer
6E0R A 1116 - 1383 Jmol OpenAstexViewer
6EBW A 1116 - 1383 Jmol OpenAstexViewer
6EDL A 1116 - 1383 Jmol OpenAstexViewer
6MX8 A 1116 - 1383 Jmol OpenAstexViewer
1274 - 1283 5VZ5 C 1 - 10 Jmol OpenAstexViewer
6AT9 C 1 - 10 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.