Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: CHIP_HUMAN (Q9UNE7)

Summary

This is the summary of UniProt entry CHIP_HUMAN (Q9UNE7).

Description: E3 ubiquitin-protein ligase CHIP {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 303 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 30
low_complexity n/a 1 17
Pfam ANAPC3 39 120
coiled_coil n/a 100 127
Pfam CHIP_TPR_N 142 225
low_complexity n/a 166 178
coiled_coil n/a 170 190
disorder n/a 176 196
Pfam U-box 227 299
disorder n/a 266 269

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UNE7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG
50
51
RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL
100
101
GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI
150
151
EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI
200
201
EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI
250
251
TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV
300
301
EDY                                                   
303
 

Show the unformatted sequence.

Checksums:
CRC64:7E7D6568B17070BF
MD5:b737f8f3f944c348123a9e232d503397

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ANAPC3 39 - 120 4KBQ A 39 - 120 Jmol OpenAstexViewer
B 39 - 120 Jmol OpenAstexViewer
CHIP_TPR_N 142 - 148 4KBQ B 142 - 148 Jmol OpenAstexViewer
142 - 153 4KBQ A 142 - 153 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.