Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TIM_HUMAN (Q9UNS1)

Summary

This is the summary of UniProt entry TIM_HUMAN (Q9UNS1).

Description: Protein timeless homolog
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1208 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 22
Pfam TIMELESS 24 284
low_complexity n/a 194 209
disorder n/a 237 238
disorder n/a 264 270
disorder n/a 312 324
low_complexity n/a 527 537
disorder n/a 587 589
disorder n/a 630 631
disorder n/a 656 679
coiled_coil n/a 662 687
low_complexity n/a 665 677
Pfam TIMELESS_C 728 1207
disorder n/a 814 822
low_complexity n/a 891 905
disorder n/a 967 998
low_complexity n/a 968 992
disorder n/a 1037 1068
low_complexity n/a 1048 1057
disorder n/a 1076 1086
disorder n/a 1090 1135
low_complexity n/a 1096 1113
low_complexity n/a 1130 1147
disorder n/a 1137 1208
low_complexity n/a 1168 1180

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UNS1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDLHMMNCEL LATCSALGYL EGDTYHKEPD CLESVKDLIR YLRHEDETRD
50
51
VRQQLGAAQI LQSDLLPILT QHHQDKPLFD AVIRLMVNLT QPALLCFGNL
100
101
PKEPSFRHHF LQVLTYLQAY KEAFASEKAF GVLSETLYEL LQLGWEERQE
150
151
EDNLLIERIL LLVRNILHVP ADLDQEKKID DDASAHDQLL WAIHLSGLDD
200
201
LLLFLASSSA EEQWSLHVLE IVSLMFRDQN PEQLAGVGQG RLAQERSADF
250
251
AELEVLRQRE MAEKKTRALQ RGNRHSRFGG SYIVQGLKSI GERDLIFHKG
300
301
LHNLRNYSSD LGKQPKKVPK RRQAARELSI QRRSALNVRL FLRDFCSEFL
350
351
ENCYNRLMGS VKDHLLREKA QQHDETYYMW ALAFFMAFNR AASFRPGLVS
400
401
ETLSVRTFHF IEQNLTNYYE MMLTDRKEAA SWARRMHLAL KAYQELLATV
450
451
NEMDISPDEA VRESSRIIKN NIFYVMEYRE LFLALFRKFD ERCQPRSFLR
500
501
DLVETTHLFL KMLERFCRSR GNLVVQNKQK KRRKKKKKVL DQAIVSGNVP
550
551
SSPEEVEAVW PALAEQLQCC AQNSELSMDS VVPFDAASEV PVEEQRAEAM
600
601
VRIQDCLLAG QAPQALTLLR SAREVWPEGD VFGSQDISPE EEIQLLKQIL
650
651
SAPLPRQQGP EERGAEEEEE EEEEEEEELQ VVQVSEKEFN FLDYLKRFAC
700
701
STVVRAYVLL LRSYQQNSAH TNHCIVKMLH RLAHDLKMEA LLFQLSVFCL
750
751
FNRLLSDPAA GAYKELVTFA KYILGKFFAL AAVNQKAFVE LLFWKNTAVV
800
801
REMTEGYGSL DDRSSSRRAP TWSPEEEAHL RELYLANKDV EGQDVVEAIL
850
851
AHLNTVPRTR KQIIHHLVQM GLADSVKDFQ RKGTHIVLWT GDQELELQRL
900
901
FEEFRDSDDV LGHIMKNITA KRSRARIVDK LLALGLVAER RELYKKRQKK
950
951
LASSILPNGA ESLKDFCQED LEEEENLPEE DSEEEEEGGS EAEQVQGSLV
1000
1001
LSNENLGQSL HQEGFSIPLL WLQNCLIRAA DDREEDGCSQ AVPLVPLTEE
1050
1051
NEEAMENEQF QQLLRKLGVR PPASGQETFW RIPAKLSPTQ LRRAAASLSQ
1100
1101
PEEEQKLQPE LQPKVPGEQG SDEEHCKEHR AQALRALLLA HKKKAGLASP
1150
1151
EEEDAVGKEP LKAAPKKRQL LDSDEEQEED EGRNRAPELG APGIQKKKRY
1200
1201
QIEDDEDD                                              
1208
 

Show the unformatted sequence.

Checksums:
CRC64:16C6C07DDC6D2701
MD5:d960c66eea311cc948947df01cac1877

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TIMELESS 24 - 238 5MQI A 24 - 238 Jmol OpenAstexViewer
TIMELESS_C 1004 - 1098 4XHT B 1004 - 1098 Jmol OpenAstexViewer
1005 - 1098 4XHT A 1005 - 1098 Jmol OpenAstexViewer
C 1005 - 1098 Jmol OpenAstexViewer
4XHW C 10 - 103 Jmol OpenAstexViewer
1006 - 1098 4XHT D 1006 - 1098 Jmol OpenAstexViewer
1007 - 1098 4XHW A 12 - 103 Jmol OpenAstexViewer
B 12 - 103 Jmol OpenAstexViewer
D 12 - 103 Jmol OpenAstexViewer
1010 - 1098 4XHU B 15 - 103 Jmol OpenAstexViewer
1016 - 1098 4XHU D 21 - 103 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.