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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: ZC3H4_HUMAN (Q9UPT8)

Summary

This is the summary of UniProt entry ZC3H4_HUMAN (Q9UPT8).

Description: Zinc finger CCCH domain-containing protein 4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1303 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 387
low_complexity n/a 2 40
low_complexity n/a 40 53
low_complexity n/a 49 70
low_complexity n/a 95 128
low_complexity n/a 130 145
low_complexity n/a 192 218
low_complexity n/a 232 274
low_complexity n/a 278 292
low_complexity n/a 285 295
low_complexity n/a 313 356
low_complexity n/a 355 381
Pfam zf-CCCH_4 394 415
Pfam zf-CCCH 420 445
disorder n/a 462 465
disorder n/a 468 967
low_complexity n/a 482 500
low_complexity n/a 505 531
low_complexity n/a 535 559
low_complexity n/a 602 654
low_complexity n/a 651 676
low_complexity n/a 745 758
low_complexity n/a 771 785
low_complexity n/a 876 889
low_complexity n/a 902 928
disorder n/a 970 975
disorder n/a 979 1049
disorder n/a 1051 1299
low_complexity n/a 1096 1109
low_complexity n/a 1124 1144
low_complexity n/a 1220 1244
disorder n/a 1301 1303

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UPT8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEAAPGTPPP PPSESPPPPS PPPPSTPSPP PCSPDARPAT PHLLHHRLPL
50
51
PDDREDGELE EGELEDDGAE ETQDTSGGPE RSRKEKGEKH HSDSDEEKSH
100
101
RRLKRKRKKE REKEKRRSKK RRKSKHKRHA SSSDDFSDFS DDSDFSPSEK
150
151
GHRKYREYSP PYAPSHQQYP PSHATPLPKK AYSKMDSKSY GMYEDYENEQ
200
201
YGEYEGDEEE DMGKEDYDDF TKELNQYRRA KEGSSRGRGS RGRGRGYRGR
250
251
GSRGGSRGRG MGRGSRGRGR GSMGGDHPED EEDFYEEEMD YGESEEPMGD
300
301
DDYDEYSKEL NQYRRSKDSR GRGLSRGRGR GSRGRGKGMG RGRGRGGSRG
350
351
GMNKGGMNDD EDFYDEDMGD GGGGSYRSRD HDKPHQQSDK KGKVICKYFV
400
401
EGRCTWGDHC NFSHDIELPK KRELCKFYIT GFCARAENCP YMHGDFPCKL
450
451
YHTTGNCING DDCMFSHDPL TEETRELLDK MLADDAEAGA EDEKEVEELK
500
501
KQGINPLPKP PPGVGLLPTP PRPPGPQAPT SPNGRPMQGG PPPPPPPPPP
550
551
PPGPPQMPMP VHEPLSPQQL QQQDMYNKKI PSLFEIVVRP TGQLAEKLGV
600
601
RFPGPGGPPG PMGPGPNMGP PGPMGGPMHP DMHPDMHPDM HPDMHADMHA
650
651
DMPMGPGMNP GPPMGPGGPP MMPYGPGDSP HSGMMPPIPP AQNFYENFYQ
700
701
QQEGMEMEPG LLGDAEDYGH YEELPGEPGE HLFPEHPLEP DSFSEGGPPG
750
751
RPKPGAGVPD FLPSAQRALY LRIQQKQQEE EERARRLAES SKQDRENEEG
800
801
DTGNWYSSDE DEGGSSVTSI LKTLRQQTSS RPPASVGELS SSGLGDPRLQ
850
851
KGHPTGSRLA DPRLSRDPRL TRHVEASGGS GPGDSGPSDP RLARALPTSK
900
901
PEGSLHSSPV GPSSSKGSGP PPTEEEEGER ALREKAVNIP LDPLPGHPLR
950
951
DPRSQLQQFS HIKKDVTLSK PSFARTVLWN PEDLIPLPIP KQDAVPPVPA
1000
1001
ALQSMPTLDP RLHRAATAGP PNARQRPGAS TDSSTQGANL PDFELLSRIL
1050
1051
KTVNATGSSA APGSSDKPSD PRVRKAPTDP RLQKPTDSTA SSRAAKPGPA
1100
1101
EAPSPTASPS GDASPPATAP YDPRVLAAGG LGQGGGGGQS SVLSGISLYD
1150
1151
PRTPNAGGKA TEPAADTGAQ PKGAEGNGKS SASKAKEPPF VRKSALEQPE
1200
1201
TGKAGADGGT PTDRYNSYNR PRPKAAAAPA ATTATPPPEG APPQPGVHNL
1250
1251
PVPTLFGTVK QTPKTGSGSP FAGNSPAREG EQDAASLKDV FKGFDPTASP
1300
1301
FCQ                                                   
1303
 

Show the unformatted sequence.

Checksums:
CRC64:A6DAE368F543FF4D
MD5:e93f61fc713b607ed5d23c86cc9655b3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
zf-CCCH 420 - 445 2CQE A 432 - 457 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.