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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RIMS2_HUMAN (Q9UQ26)

Summary

This is the summary of UniProt entry RIMS2_HUMAN (Q9UQ26).

Description: Regulating synaptic membrane exocytosis protein 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1411 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 56
Pfam FYVE_2 67 185
low_complexity n/a 70 88
disorder n/a 74 119
coiled_coil n/a 96 116
low_complexity n/a 107 115
disorder n/a 179 649
low_complexity n/a 271 286
low_complexity n/a 345 366
low_complexity n/a 523 536
low_complexity n/a 541 551
low_complexity n/a 557 570
disorder n/a 677 682
Pfam PDZ_6 697 754
disorder n/a 762 765
disorder n/a 767 777
low_complexity n/a 770 778
disorder n/a 779 793
Pfam C2 820 930
low_complexity n/a 855 866
disorder n/a 859 865
disorder n/a 932 934
disorder n/a 938 969
disorder n/a 971 972
disorder n/a 986 1217
low_complexity n/a 1095 1111
low_complexity n/a 1126 1140
disorder n/a 1259 1260
Pfam C2 1270 1377
disorder n/a 1395 1396
disorder n/a 1399 1411

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UQ26. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK
50
51
VKEEHKPQLT QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK
100
101
EQVKKMGEES QQQQEQKGDA PTCGICHKTK FADGCGHNCS YCQTKFCARC
150
151
GGRVSLRSNK VMWVCNLCRK QQEILTKSGA WFYNSGSNTP QQPDQKVLRG
200
201
LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL TRQHSIKNGS
250
251
GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS
300
301
PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE
350
351
YERQRREEEY QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS
400
401
DVSLANADLE DSRISMLRMD RPSRQRSISE RRAAMENQRS YSMERTREAQ
450
451
GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR RTDSLRKQHH LDPSSAVRKT
500
501
KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ ISLSSSEEEL
550
551
ASTPEYTSCD DVEIESESVS EKGDSQKGKR KTSEQAVLSD SNTRSERQKE
600
601
MMYFGGHSLE EDLEWSEPQI KDSGVDTCSS TTLNEEHSHS DKHPVTWQPS
650
651
KDGDRLIGRI LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK
700
701
VKKGSLADTV GHLRPGDEVL EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL
750
751
VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ KMDRPSISVT SPMSPGMLRD
800
801
VPQFLSGQLS IKLWFDKVGH QLIVTILGAK DLPSREDGRP RNPYVKIYFL
850
851
PDRSDKNKRR TKTVKKTLEP KWNQTFIYSP VHRREFRERM LEITLWDQAR
900
901
VREEESEFLG EILIELETAL LDDEPHWYKL QTHDVSSLPL PHPSPYMPRR
950
951
QLHGESPTRR LQRSKRISDS EVSDYDCDDG IGVVSDYRHD GRDLQSSTLS
1000
1001
VPEQVMSSNH CSPSGSPHRV DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT
1050
1051
MTGHYNTISR MDRHRVMDDH YSPDRDRDCE AADRQPYHRS RSTEQRPLLE
1100
1101
RTTTRSRSTE RPDTNLMRSM PSLMTGRSAP PSPALSRSHP RTGSVQTSPS
1150
1151
STPVAGRRGR QLPQLPPKGT LDRKAGGKKL RSTVQRSTET GLAVEMRNWM
1200
1201
TRQASRESTD GSMNSYSSEG NLIFPGVRLA SDSQFSDFLD GLGPAQLVGR
1250
1251
QTLATPAMGD IQVGMMDKKG QLEVEIIRAR GLVVKPGSKT LPAPYVKVYL
1300
1301
LDNGVCIAKK KTKVARKTLE PLYQQLLSFE ESPQGKVLQI IVWGDYGRMD
1350
1351
HKSFMGVAQI LLDELELSNM VIGWFKLFPP SSLVDPTLAP LTRRASQSSL
1400
1401
ESSTGPSYSR S                                          
1411
 

Show the unformatted sequence.

Checksums:
CRC64:9D4E83F4CBE4A864
MD5:ee3ad146dc4732c9252e9c9152d3d771

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C2 820 - 930 1V27 A 21 - 131 Jmol OpenAstexViewer
PDZ_6 697 - 754 1WFG A 68 - 125 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.