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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KDM5_DROME (Q9VMJ7)

Summary

This is the summary of UniProt entry KDM5_DROME (Q9VMJ7).

Description: Lysine-specific demethylase lid
Source organism: Drosophila melanogaster (Fruit fly) (NCBI taxonomy ID 7227)
Length: 1838 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 153
low_complexity n/a 9 37
low_complexity n/a 41 56
low_complexity n/a 120 129
disorder n/a 155 160
Pfam JmjN 162 195
disorder n/a 163 166
Pfam ARID 228 312
disorder n/a 271 286
disorder n/a 318 380
low_complexity n/a 321 333
disorder n/a 387 394
disorder n/a 416 437
Pfam PHD 450 498
Pfam JmjC 624 740
Pfam zf-C5HC2 830 882
Pfam PLU-1 895 1231
coiled_coil n/a 1011 1031
low_complexity n/a 1014 1031
low_complexity n/a 1044 1058
coiled_coil n/a 1096 1116
coiled_coil n/a 1153 1173
disorder n/a 1278 1283
Pfam PHD 1295 1354
disorder n/a 1326 1339
disorder n/a 1346 1347
low_complexity n/a 1363 1377
disorder n/a 1395 1494
low_complexity n/a 1407 1418
low_complexity n/a 1452 1463
low_complexity n/a 1505 1516
disorder n/a 1507 1514
disorder n/a 1516 1517
disorder n/a 1519 1762
low_complexity n/a 1544 1555
low_complexity n/a 1576 1597
low_complexity n/a 1623 1653
low_complexity n/a 1658 1684
low_complexity n/a 1691 1722
low_complexity n/a 1718 1737
low_complexity n/a 1741 1759
Pfam PHD 1756 1808
disorder n/a 1816 1838

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9VMJ7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSAKTEADNT TAANSGGGGV GSGTSSGGGA SANGTATPAR RLRTRNSTGN
50
51
GTNSGSESVK KSNANDEPST PVTPAGATGS HTHAPPGISP AVMERPMPSV
100
101
PMNHASSSVS ASKKYHNSCP HPTPTPAPTG HKKSVHTQPH SSNKFDQGKN
150
151
EEFHFDTPPE CPVFRPTTEE FKNPLAYISK IRSIAEKCGI AKILPPATWS
200
201
PPFAVDVDKL RFVPRVQRLN ELEAKTRVKL NFLDQIAKFW ELQGSSLKIP
250
251
MVERKALDLY TLHRIVQEEG GMEQTTKDRK WAKVANRMQY PSSKSVGATL
300
301
KAHYERILHP FEVYTSGKVL GPTPTSSGSG STPVKLEDGG GTDYKAHEIP
350
351
TRQQIAPPNE TNTRRSKRFG NSNASCGLSG VTPTTKPSAG VFVKTETKEE
400
401
FKRDLLSSFN AVNSGGSPLA TGTTANTRGA SQKKGGEPPA LIVDPLMKYI
450
451
CHICNRGDVE ESMLLCDGCD DSYHTFCLLP PLTSIPKGEW LCPRCVVEEV
500
501
SKPQEAFGFE QAEREYTLQQ FGQMADQFKQ EYFRKPVHLV PTEMVEREFW
550
551
RIVSSIDEDV TVEYGADLHT MDHGSGFPTK SSLYLLPGDQ EYAESSWNLN
600
601
NLPLLEDSIL GHINADISGM NAPWMYVGMC FAAFCWHNED HWSYSINYLH
650
651
WGEPKTWYGV PGSCAEQFEE TMKQAAPELF SSQPDLLHQL VTIMNPNILM
700
701
NNRVPVFRTD QHAGEFVITF PRAYHAGFNQ GYNFAEAVNF APADWLKMGR
750
751
ECVNHYSMLR RFCVFSHDEL VCKMALEPAK LTFGIATACY IDMAEMVDTE
800
801
KKLRKSLLEW GVTRAERRAF ELVNDDERHC QECNTTCFLS AVACECNDKL
850
851
IVCLRHYTVL CGCAPEKHTL IYRYTLDEMP LMLQKLKVKA HSFERWLSRC
900
901
RDIVDAHTPT SVTLQELQEL CKEAETKKFP SSLLIDRLNA AAVEAEKCVT
950
951
VIQQLGINKV RTRSDHNQEA AQYKLTMEEL ELFVQEIDNL CCIIDEGASV
1000
1001
RELLVLGKQF VERSESQLQL SLESLEESEL ETLINEGSSL RIELQQLDLL
1050
1051
QKRLKQCKWY KRSQGLRETS SKLTYQDVKN LLHIAAADLD PTDPYVDKEM
1100
1101
RKLQQIGADI EAWESQAAKY FRRLTQQHEL GEIEQFLKSA SDINGQVPSH
1150
1151
GLLKDALRKA REWLRAVEQL QQNNHVTYCH TLEAMIERGL NIPIQLEELS
1200
1201
RMQGHLNSAH QWKDNTACAF LKKGTFYTLL EVLMPRSDAI NIDSDLKPRF
1250
1251
QDDFLKEKNP AEIVASFKHA EEQELLDMRE LRRQNMNKNP MRDMFCLCKS
1300
1301
EFRNLMFNCQ LCRDWFHEDC VPPPSATNQN GIVNGGSGPG TNRPKWLCPS
1350
1351
CVRSKRPRLE TILPLLVQLQ QLPIRLPEDE ALRCLAERAM NWQDRARKAL
1400
1401
SSPDVSAAQE AIMAQQQQKR RSEGGAGVGN ISSPRKPRRR GSLTKEASGS
1450
1451
TESDADDDDD EDECRLRIVE DNFSNDEDEP RTAPATSTVN SDLLKLLSDS
1500
1501
EIENLLDLMM EGDLLEVSLD ETQELWRILE TMPPTLLQAE AMERVVQYMQ
1550
1551
RQRQQHTNPL PTSGAEDSND SLMVQNSPNS NSNSGGATGS ASNSGRNKKR
1600
1601
RSNDTGGNSA VPRKKQSTPK QTPGKKGSAA AARKSDAKAS PAASTTPGAD
1650
1651
ADAENKQANG GNTNSSTGSG GGNSATTTPT PGSTHKKRKR TSTTATNNNN
1700
1701
NNNNNSTNNS NSSTNLNSNT TSGQGAATGG NNATGGQKKH AQRSQQAAQE
1750
1751
DDEEECRAEN CHKPTGREVD WVQCDGGCNE WFHMYCVGLN RSQIKPDDDY
1800
1801
ICIRCTKTVA IGTQGSGHSM SVASTTTPGK QRAVQSAR             
1838
 

Show the unformatted sequence.

Checksums:
CRC64:E01BDB89027F9F50
MD5:2cd8195c5307f534d53cce3bc51a59ff

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ARID 228 - 312 2LM1 A 228 - 312 Show 3D Structure View in InterPro
PHD 450 - 498 2MIQ A 40 - 88 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;