Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TLE2_MOUSE (Q9WVB2)

Summary

This is the summary of UniProt entry TLE2_MOUSE (Q9WVB2).

Description: Transducin-like enhancer protein 2
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 767 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 7
Pfam TLE_N 17 65
coiled_coil n/a 25 52
disorder n/a 60 63
Pfam TLE_N 82 156
disorder n/a 141 142
low_complexity n/a 141 155
disorder n/a 147 168
low_complexity n/a 167 194
disorder n/a 195 352
low_complexity n/a 206 228
low_complexity n/a 296 311
disorder n/a 360 366
low_complexity n/a 366 386
disorder n/a 422 424
Pfam WD40 472 508
Pfam WD40 565 599
Pfam WD40 603 641

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9WVB2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MYPQGRHPTP LQSGQPFKFS VLEICDRIKE EFQFLQAQYH SLKLECEKLA
50
51
SEKTEMQRHY VMAAPHQCPQ GGTSYPHWPR LSPLQYYEMS YGLNIEMHKQ
100
101
AEIVKRLSAI CAQMVPFLTQ EHQQQVLQAV DRAKQVTVGE LNSLLGQQNQ
150
151
LQPLSHAPPV PLTPRPAGLV GAGATGLLAL SGALAAQAQL VAAVKEDRVG
200
201
VDAEGSRVDR AASRSSSPSP PESLVEEDHP SSRGGSGKQQ RAEDKDLSGP
250
251
YDSEEDKSDY NLVVDEDQPS EPPSPVTTPC GKAPLCIPAR RDLTDSPASL
300
301
ASSLGSPLPR SKDIALNDLP TGTPASRSCG TSPPQDSSTP GPSSASHLCQ
350
351
LAAQPAAPTD SIALRSPLTL SSPFTSSFSL GSHSTLNGDL SMPGSYVGLH
400
401
LSPQVSSSVV YGRSPLQMAF ESHPHLRGSS VSLPGIPVAK PAYSFHVSAD
450
451
GQMQPVPFPS DALVGTGIPR HARQLHTLAH GEVVCAVTIS SSTQHVYTGG
500
501
KGCVKVWDVG QPGSKTPVAQ LDCLNRDNYI RSCKLLPDGQ SLIVGGEAST
550
551
LSIWDLAAPT PRIKAELTSS APACYALAVS PDAKVCFSCC SDGNIVVWDL
600
601
QNQAMVRQFQ GHTDGASCID ISDYGTRLWT GGLDNTVRCW DLREGRQLQQ
650
651
HDFSSQIFSL GHCPNQDWLA VGMESSHVEV LHVRKPEKYQ LRLHESCVLS
700
701
LKFASCGRWF VSTGKDNLLN AWRTPYGASI FQSKESSSVL SCDISRNNKY
750
751
IVTGSGDKKA TVYEVVY                                    
767
 

Show the unformatted sequence.

Checksums:
CRC64:2BECE931EE993C44
MD5:08236ecb7cf3f7f2b2197ed5dd6cf4a9

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;