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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HPSE_HUMAN (Q9Y251)

Summary

This is the summary of UniProt entry HPSE_HUMAN (Q9Y251).

Description: Heparanase EC=3.2.1.166
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 543 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 35
low_complexity n/a 7 33
Pfam Glyco_hydro_79n 146 370

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y251. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLLRSKPALP PPLMLLLLGP LGPLSPGALP RPAQAQDVVD LDFFTQEPLH
50
51
LVSPSFLSVT IDANLATDPR FLILLGSPKL RTLARGLSPA YLRFGGTKTD
100
101
FLIFDPKKES TFEERSYWQS QVNQDICKYG SIPPDVEEKL RLEWPYQEQL
150
151
LLREHYQKKF KNSTYSRSSV DVLYTFANCS GLDLIFGLNA LLRTADLQWN
200
201
SSNAQLLLDY CSSKGYNISW ELGNEPNSFL KKADIFINGS QLGEDFIQLH
250
251
KLLRKSTFKN AKLYGPDVGQ PRRKTAKMLK SFLKAGGEVI DSVTWHHYYL
300
301
NGRTATKEDF LNPDVLDIFI SSVQKVFQVV ESTRPGKKVW LGETSSAYGG
350
351
GAPLLSDTFA AGFMWLDKLG LSARMGIEVV MRQVFFGAGN YHLVDENFDP
400
401
LPDYWLSLLF KKLVGTKVLM ASVQGSKRRK LRVYLHCTNT DNPRYKEGDL
450
451
TLYAINLHNV TKYLRLPYPF SNKQVDKYLL RPLGPHGLLS KSVQLNGLTL
500
501
KMVDDQTLPP LMEKPLRPGS SLGLPAFSYS FFVIRNAKVA ACI       
543
 

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Checksums:
CRC64:A990F5AFD639CA1A
MD5:ff091910c1ec0409fb2e85b4b7cb42a2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Glyco_hydro_79n 146 - 370 5LA4 A 146 - 370 Show 3D Structure View in InterPro
5LA7 A 146 - 370 Show 3D Structure View in InterPro
159 - 370 5E8M A 159 - 370 Show 3D Structure View in InterPro
5E97 A 159 - 370 Show 3D Structure View in InterPro
5E98 A 159 - 370 Show 3D Structure View in InterPro
5E9B A 159 - 370 Show 3D Structure View in InterPro
5E9C A 159 - 370 Show 3D Structure View in InterPro
5L9Z A 159 - 370 Show 3D Structure View in InterPro
6ZDM AAA 159 - 370 Show 3D Structure View in InterPro
160 - 370 5L9Y A 160 - 370 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;