!!

Powering down the Pfam website
On October 5th, we will start redirecting the traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will be available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TPPC8_HUMAN (Q9Y2L5)

Summary

This is the summary of UniProt entry TPPC8_HUMAN (Q9Y2L5).

Description: Trafficking protein particle complex subunit 8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1435 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam TRAPPC-Trs85 157 604
disorder n/a 161 168
disorder n/a 206 212
disorder n/a 235 254
disorder n/a 256 257
disorder n/a 259 268
low_complexity n/a 269 285
disorder n/a 278 279
disorder n/a 281 283
disorder n/a 288 327
disorder n/a 689 698
low_complexity n/a 765 777
disorder n/a 790 792
disorder n/a 879 886
disorder n/a 888 894
disorder n/a 1211 1218

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y2L5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQCVQSVQE LIPDSFVPCV AALCSDEAER LTRLNHLSFA ELLKPFSRLT
50
51
SEVHMRDPNN QLHVIKNLKI AVSNIVTQPP QPGAIRKLLN DVVSGSQPAE
100
101
GLVANVITAG DYDLNISATT PWFESYRETF LQSMPALDHE FLNHYLACML
150
151
VASSSEAEPV EQFSKLSQEQ HRIQHNSDYS YPKWFIPNTL KYYVLLHDVS
200
201
AGDEQRAESI YEEMKQKYGT QGCYLLKINS RTSNRASDEQ IPDPWSQYLQ
250
251
KNSIQNQESY EDGPCTITSN KNSDNNLLSL DGLDNEVKDG LPNNFRAHPL
300
301
QLEQSSDPSN SIDGPDHLRS ASSLHETKKG NTGIIHGACL TLTDHDRIRQ
350
351
FIQEFTFRGL LPHIEKTIRQ LNDQLISRKG LSRSLFSATK KWFSGSKVPE
400
401
KSINDLKNTS GLLYPPEAPE LQIRKMADLC FLVQHYDLAY SCYHTAKKDF
450
451
LNDQAMLYAA GALEMAAVSA FLQPGAPRPY PAHYMDTAIQ TYRDICKNMV
500
501
LAERCVLLSA ELLKSQSKYS EAAALLIRLT SEDSDLRSAL LLEQAAHCFI
550
551
NMKSPMVRKY AFHMILAGHR FSKAGQKKHA LRCYCQAMQV YKGKGWSLAE
600
601
DHINFTIGRQ SYTLRQLDNA VSAFRHILIN ESKQSAAQQG AFLREYLYVY
650
651
KNVSQLSPDG PLPQLPLPYI NSSATRVFFG HDRRPADGEK QAATHVSLDQ
700
701
EYDSESSQQW RELEEQVVSV VNKGVIPSNF HPTQYCLNSY SDNSRFPLAV
750
751
VEEPITVEVA FRNPLKVLLL LTDLSLLWKF HPKDFSGKDN EEVKQLVTSE
800
801
PEMIGAEVIS EFLINGEESK VARLKLFPHH IGELHILGVV YNLGTIQGSM
850
851
TVDGIGALPG CHTGKYSLSM SVRGKQDLEI QGPRLNNTKE EKTSVKYGPD
900
901
RRLDPIITEE MPLLEVFFIH FPTGLLCGEI RKAYVEFVNV SKCPLTGLKV
950
951
VSKRPEFFTF GGNTAVLTPL SPSASENCSA YKTVVTDATS VCTALISSAS
1000
1001
SVDFGIGTGS QPEVIPVPLP DTVLLPGASV QLPMWLRGPD EEGVHEINFL
1050
1051
FYYESVKKQP KIRHRILRHT AIICTSRSLN VRATVCRSNS LENEEGRGGN
1100
1101
MLVFVDVENT NTSEAGVKEF HIVQVSSSSK HWKLQKSVNL SENKDTKLAS
1150
1151
REKGKFCFKA IRCEKEEAAT QSSEKYTFAD IIFGNEQIIS SASPCADFFY
1200
1201
RSLSSELKKP QAHLPVHTEK QSTEDAVRLI QKCSEVDLNI VILWKAYVVE
1250
1251
DSKQLILEGQ HHVILRTIGK EAFSYPQKQE PPEMELLKFF RPENITVSSR
1300
1301
PSVEQLSSLI KTSLHYPESF NHPFHQKSLC LVPVTLLLSN CSKADVDVIV
1350
1351
DLRHKTTSPE ALEIHGSFTW LGQTQYKLQL KSQEIHSLQL KACFVHTGVY
1400
1401
NLGTPRVFAK LSDQVTVFET SQQNSMPALI IISNV                
1435
 

Show the unformatted sequence.

Checksums:
CRC64:A6D60A7C9E65F46D
MD5:598a7ed8ad414d0c5ce6290e53df8f8e

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;