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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SYYM_HUMAN (Q9Y2Z4)

Summary

This is the summary of UniProt entry SYYM_HUMAN (Q9Y2Z4).

Description: Tyrosine--tRNA ligase, mitochondrial
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 477 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam tRNA-synt_1b 71 375
low_complexity n/a 87 101
disorder n/a 122 132
low_complexity n/a 136 153
disorder n/a 335 337
disorder n/a 340 341
disorder n/a 343 344
disorder n/a 348 351

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y2Z4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAPILRSFS WGRWSGTLNL SVLLPLGLRK AHSGAQGLLA AQKARGLFKD
50
51
FFPETGTKIE LPELFDRGTA SFPQTIYCGF DPTADSLHVG HLLALLGLFH
100
101
LQRAGHNVIA LVGGATARLG DPSGRTKERE ALETERVRAN ARALRLGLEA
150
151
LAANHQQLFT DGRSWGSFTV LDNSAWYQKQ HLVDFLAAVG GHFRMGTLLS
200
201
RQSVQLRLKS PEGMSLAEFF YQVLQAYDFY YLFQRYGCRV QLGGSDQLGN
250
251
IMSGYEFINK LTGEDVFGIT VPLITSTTGA KLGKSAGNAV WLNRDKTSPF
300
301
ELYQFFVRQP DDSVERYLKL FTFLPLPEID HIMQLHVKEP ERRGPQKRLA
350
351
AEVTKLVHGR EGLDSAKRCT QALYHSSIDA LEVMSDQELK ELFKEAPFSE
400
401
FFLDPGTSVL DTCRKANAIP DGPRGYRMIT EGGVSINHQQ VTNPESVLIV
450
451
GQHILKNGLS LLKIGKRNFY IIKWLQL                         
477
 

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Checksums:
CRC64:C513B8FE1E7A09E4
MD5:b16b2e18a0b40db93fc8ae61656f3afa

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
tRNA-synt_1b 71 - 373 2PID B 71 - 373 Show 3D Structure View in InterPro
73 - 373 2PID A 73 - 373 Show 3D Structure View in InterPro
73 - 374 3ZXI A 73 - 374 Show 3D Structure View in InterPro
B 73 - 374 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;