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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: NR2E1_HUMAN (Q9Y466)

Summary

This is the summary of UniProt entry NR2E1_HUMAN (Q9Y466).

Description: Nuclear receptor subfamily 2 group E member 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 385 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 2
Pfam zf-C4 14 85
disorder n/a 86 87
disorder n/a 89 94
low_complexity n/a 115 132
disorder n/a 156 164
Pfam Hormone_recep 172 367
coiled_coil n/a 258 278
low_complexity n/a 310 315
low_complexity n/a 342 346

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y466. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSKPAGSTSR ILDIPCKVCG DRSSGKHYGV YACDGCSGFF KRSIRRNRTY
50
51
VCKSGNQGGC PVDKTHRNQC RACRLKKCLE VNMNKDAVQH ERGPRTSTIR
100
101
KQVALYFRGH KEENGAAAHF PSAALPAPAF FTAVTQLEPH GLELAAVSTT
150
151
PERQTLVSLA QPTPKYPHEV NGTPMYLYEV ATESVCESAA RLLFMSIKWA
200
201
KSVPAFSTLS LQDQLMLLED AWRELFVLGI AQWAIPVDAN TLLAVSGMNG
250
251
DNTDSQKLNK IISEIQALQE VVARFRQLRL DATEFACLKC IVTFKAVPTH
300
301
SGSELRSFRN AAAIAALQDE AQLTLNSYIH TRYPTQPCRF GKLLLLLPAL
350
351
RSISPSTIEE VFFKKTIGNV PITRLLSDMY KSSDI                
385
 

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Checksums:
CRC64:39181A42A2FB79C2
MD5:d4fe858d96f0a1b7c62d80822d57bf2c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Hormone_recep 182 - 367 4XAJ A 1182 - 1367 Jmol OpenAstexViewer
B 1182 - 1367 Jmol OpenAstexViewer
C 1182 - 1367 Jmol OpenAstexViewer
D 1182 - 1367 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.