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28  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: STK24_HUMAN (Q9Y6E0)

Summary

This is the summary of UniProt entry STK24_HUMAN (Q9Y6E0).

Description: Serine/threonine-protein kinase 24 EC=2.7.11.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 443 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 21 27
Pfam Pkinase 36 286
coiled_coil n/a 62 89
low_complexity n/a 62 82
disorder n/a 237 239
disorder n/a 253 254
disorder n/a 307 329
low_complexity n/a 308 324
low_complexity n/a 324 335
disorder n/a 333 337
disorder n/a 349 366
disorder n/a 441 442

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y6E0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDSRAQLWGL ALNKRRATLP HPGGSTNLKA DPEELFTKLE KIGKGSFGEV
50
51
FKGIDNRTQK VVAIKIIDLE EAEDEIEDIQ QEITVLSQCD SPYVTKYYGS
100
101
YLKDTKLWII MEYLGGGSAL DLLEPGPLDE TQIATILREI LKGLDYLHSE
150
151
KKIHRDIKAA NVLLSEHGEV KLADFGVAGQ LTDTQIKRNT FVGTPFWMAP
200
201
EVIKQSAYDS KADIWSLGIT AIELARGEPP HSELHPMKVL FLIPKNNPPT
250
251
LEGNYSKPLK EFVEACLNKE PSFRPTAKEL LKHKFILRNA KKTSYLTELI
300
301
DRYKRWKAEQ SHDDSSSEDS DAETDGQASG GSDSGDWIFT IREKDPKNLE
350
351
NGALQPSDLD RNKMKDIPKR PFSQCLSTII SPLFAELKEK SQACGGNLGS
400
401
IEELRGAIYL AEEACPGISD TMVAQLVQRL QRYSLSGGGT SSH       
443
 

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Checksums:
CRC64:4A9FF1F6B6A88A97
MD5:3ddf02bac0f78c1fd4c1f0a93ab1c58d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 36 - 286 3A7F A 24 - 274 Jmol OpenAstexViewer
3A7G A 24 - 274 Jmol OpenAstexViewer
B 24 - 274 Jmol OpenAstexViewer
3A7H A 24 - 274 Jmol OpenAstexViewer
B 24 - 274 Jmol OpenAstexViewer
3A7I A 24 - 274 Jmol OpenAstexViewer
3A7J A 24 - 274 Jmol OpenAstexViewer
3CKW A 9 - 259 Jmol OpenAstexViewer
3CKX A 9 - 259 Jmol OpenAstexViewer
3ZHP C 24 - 274 Jmol OpenAstexViewer
D 24 - 274 Jmol OpenAstexViewer
4O27 B 24 - 274 Jmol OpenAstexViewer
4QML A 24 - 274 Jmol OpenAstexViewer
4QMM A 24 - 274 Jmol OpenAstexViewer
4QMN A 24 - 274 Jmol OpenAstexViewer
4QMO A 24 - 274 Jmol OpenAstexViewer
4QMP A 24 - 274 Jmol OpenAstexViewer
4QMQ A 24 - 274 Jmol OpenAstexViewer
4QMS A 24 - 274 Jmol OpenAstexViewer
4QMT A 24 - 274 Jmol OpenAstexViewer
4QMU A 24 - 274 Jmol OpenAstexViewer
4QMV A 24 - 274 Jmol OpenAstexViewer
4QMW A 24 - 274 Jmol OpenAstexViewer
4QMX A 24 - 274 Jmol OpenAstexViewer
4QMY A 24 - 274 Jmol OpenAstexViewer
4QMZ A 24 - 274 Jmol OpenAstexViewer
4QNA A 24 - 274 Jmol OpenAstexViewer
4QO9 A 24 - 274 Jmol OpenAstexViewer
B 24 - 274 Jmol OpenAstexViewer
4U8Z A 24 - 274 Jmol OpenAstexViewer
4W8D A 24 - 274 Jmol OpenAstexViewer
4W8E A 24 - 274 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.