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16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PARP3_HUMAN (Q9Y6F1)

Summary

This is the summary of UniProt entry PARP3_HUMAN (Q9Y6F1).

Description: Protein mono-ADP-ribosyltransferase PARP3 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 533 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 34
disorder n/a 48 51
disorder n/a 65 70
Pfam WGR 66 144
low_complexity n/a 67 80
disorder n/a 129 131
disorder n/a 136 138
low_complexity n/a 154 169
disorder n/a 178 180
Pfam PARP_reg 183 319
low_complexity n/a 231 240
disorder n/a 237 238
disorder n/a 241 247
disorder n/a 265 266
disorder n/a 269 277
disorder n/a 305 310
Pfam PARP 333 533
disorder n/a 354 358
disorder n/a 369 370
transmembrane n/a 381 401
disorder n/a 451 493
low_complexity n/a 489 503

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y6F1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAPKPKPWVQ TEGPEKKKGR QAGREEDPFR STAEALKAIP AEKRIIRVDP
50
51
TCPLSSNPGT QVYEDYNCTL NQTNIENNNN KFYIIQLLQD SNRFFTCWNR
100
101
WGRVGEVGQS KINHFTRLED AKKDFEKKFR EKTKNNWAER DHFVSHPGKY
150
151
TLIEVQAEDE AQEAVVKVDR GPVRTVTKRV QPCSLDPATQ KLITNIFSKE
200
201
MFKNTMALMD LDVKKMPLGK LSKQQIARGF EALEALEEAL KGPTDGGQSL
250
251
EELSSHFYTV IPHNFGHSQP PPINSPELLQ AKKDMLLVLA DIELAQALQA
300
301
VSEQEKTVEE VPHPLDRDYQ LLKCQLQLLD SGAPEYKVIQ TYLEQTGSNH
350
351
RCPTLQHIWK VNQEGEEDRF QAHSKLGNRK LLWHGTNMAV VAAILTSGLR
400
401
IMPHSGGRVG KGIYFASENS KSAGYVIGMK CGAHHVGYMF LGEVALGREH
450
451
HINTDNPSLK SPPPGFDSVI ARGHTEPDPT QDTELELDGQ QVVVPQGQPV
500
501
PCPEFSSSTF SQSEYLIYQE SQCRLRYLLE VHL                  
533
 

Show the unformatted sequence.

Checksums:
CRC64:6296A0E439CC7767
MD5:1c3b86c789be5a2c4de7b7f5549a54d1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PARP 333 - 532 3C49 A 333 - 532 Show 3D Structure View in InterPro
3C4H A 333 - 532 Show 3D Structure View in InterPro
3CE0 A 333 - 532 Show 3D Structure View in InterPro
3FHB A 333 - 532 Show 3D Structure View in InterPro
4GV0 A 333 - 532 Show 3D Structure View in InterPro
4GV2 A 333 - 532 Show 3D Structure View in InterPro
4GV4 A 333 - 532 Show 3D Structure View in InterPro
4L6Z A 333 - 532 Show 3D Structure View in InterPro
4L70 A 333 - 532 Show 3D Structure View in InterPro
4L7L A 333 - 532 Show 3D Structure View in InterPro
4L7N A 333 - 532 Show 3D Structure View in InterPro
4L7O A 333 - 532 Show 3D Structure View in InterPro
4L7P A 333 - 532 Show 3D Structure View in InterPro
4L7R A 333 - 532 Show 3D Structure View in InterPro
4L7U A 333 - 532 Show 3D Structure View in InterPro
PARP_reg 183 - 319 3C49 A 183 - 319 Show 3D Structure View in InterPro
3C4H A 183 - 319 Show 3D Structure View in InterPro
3CE0 A 183 - 319 Show 3D Structure View in InterPro
3FHB A 183 - 319 Show 3D Structure View in InterPro
4GV0 A 183 - 319 Show 3D Structure View in InterPro
4GV2 A 183 - 319 Show 3D Structure View in InterPro
4GV4 A 183 - 319 Show 3D Structure View in InterPro
4L6Z A 183 - 319 Show 3D Structure View in InterPro
4L70 A 183 - 319 Show 3D Structure View in InterPro
4L7L A 183 - 319 Show 3D Structure View in InterPro
4L7N A 183 - 319 Show 3D Structure View in InterPro
4L7O A 183 - 319 Show 3D Structure View in InterPro
4L7P A 183 - 319 Show 3D Structure View in InterPro
4L7R A 183 - 319 Show 3D Structure View in InterPro
4L7U A 183 - 319 Show 3D Structure View in InterPro
WGR 66 - 144 2EOC A 66 - 144 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;