Summary
This is the summary of UniProt entry PIAS3_HUMAN (Q9Y6X2).
| Description: | E3 SUMO-protein ligase PIAS3 EC=2.3.2.- |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 628 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| low_complexity | n/a | 33 | 45 |
| low_complexity | n/a | 69 | 92 |
| disorder | n/a | 75 | 84 |
| disorder | n/a | 86 | 95 |
| low_complexity | n/a | 89 | 108 |
| disorder | n/a | 98 | 100 |
| disorder | n/a | 111 | 123 |
| Pfam | PINIT | 126 | 278 |
| disorder | n/a | 226 | 242 |
| disorder | n/a | 244 | 245 |
| Pfam | zf-MIZ | 323 | 372 |
| disorder | n/a | 429 | 436 |
| disorder | n/a | 438 | 456 |
| disorder | n/a | 458 | 466 |
| disorder | n/a | 481 | 482 |
| disorder | n/a | 486 | 499 |
| disorder | n/a | 543 | 547 |
| disorder | n/a | 579 | 586 |
| disorder | n/a | 588 | 615 |
| low_complexity | n/a | 607 | 616 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Y6X2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA
50 51
PSVQMKIKEL YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP GPLAPIPPTL
100 101
LAPGTLLGPK REVDMHPPLP QPVHPDVTMK PLPFYEVYGE LIRPTTLAST
150 151
SSQRFEEAHF TFALTPQQVQ QILTSREVLP GAKCDYTIQV QLRFCLCETS
200 201
CPQEDYFPPN LFVKVNGKLC PLPGYLPPTK NGAEPKRPSR PINITPLARL
250 251
SATVPNTIVV NWSSEFGRNY SLSVYLVRQL TAGTLLQKLR AKGIRNPDHS
300 301
RALIKEKLTA DPDSEVATTS LRVSLMCPLG KMRLTVPCRA LTCAHLQSFD
350 351
AALYLQMNEK KPTWTCPVCD KKAPYESLII DGLFMEILSS CSDCDEIQFM
400 401
EDGSWCPMKP KKEASEVCPP PGYGLDGLQY SPVQGGDPSE NKKKVEVIDL
450 451
TIESSSDEED LPPTKKHCSV TSAAIPALPG SKGVLTSGHQ PSSVLRSPAM
500 501
GTLGGDFLSS LPLHEYPPAF PLGADIQGLD LFSFLQTESQ HYGPSVITSL
550 551
DEQDALGHFF QYRGTPSHFL GPLAPTLGSS HCSATPAPPP GRVSSIVAPG
600 601
GALREGHGGP LPSGPSLTGC RSDIISLD
628
Show the unformatted sequence. |
| Checksums: |
CRC64:7C06EF599D48F87D
MD5:a43db6f9b8044cdb846734b6fd4f8196
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| PINIT | 126 - 278 | 4MVT | A | 126 - 278 | Jmol OpenAstexViewer |
| B | 126 - 278 | Jmol OpenAstexViewer | |||
| C | 126 - 278 | Jmol OpenAstexViewer | |||
| D | 126 - 278 | Jmol OpenAstexViewer | |||
| zf-MIZ | 323 - 372 | 4MVT | A | 323 - 372 | Jmol OpenAstexViewer |
| B | 323 - 372 | Jmol OpenAstexViewer | |||
| C | 323 - 372 | Jmol OpenAstexViewer | |||
| D | 323 - 372 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
