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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: W8C8J2_RAT (W8C8J2)

Summary

This is the summary of UniProt entry W8C8J2_RAT (W8C8J2).

Description: [Histone H3]-trimethyl-L-lysine(4) demethylase {ECO:0000256|ARBA:ARBA00012902}
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
Length: 1550 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 5
Pfam JmjN 15 48
Pfam ARID 81 165
disorder n/a 175 194
disorder n/a 212 213
disorder n/a 215 234
disorder n/a 257 260
disorder n/a 262 264
Pfam PHD 325 373
Pfam JmjC 500 616
Pfam zf-C5HC2 706 758
Pfam PLU-1 771 1096
low_complexity n/a 839 853
low_complexity n/a 913 929
coiled_coil n/a 962 982
low_complexity n/a 1147 1156
disorder n/a 1157 1159
coiled_coil n/a 1293 1313
disorder n/a 1310 1335
disorder n/a 1341 1346
disorder n/a 1351 1354
disorder n/a 1357 1361
disorder n/a 1363 1365
disorder n/a 1370 1373
disorder n/a 1377 1380
disorder n/a 1383 1404
low_complexity n/a 1395 1406
disorder n/a 1415 1418
disorder n/a 1420 1421
disorder n/a 1427 1545
low_complexity n/a 1453 1459
low_complexity n/a 1525 1541

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession W8C8J2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKPESDDFLP PPECPVFEPS WAEFRDPLGY IAKIRPIAEK SGICKIRPPA
50
51
DWQPPFAVEI DNFRFTPRIQ RLNELEAQTR VKLNYLDQIA KFWEIQGSSL
100
101
KIPNVERKIL DLYSLNKIVI EEGGYEAICK DRRWARVAQR LNYPSGKNIG
150
151
SLLRSHYERI IYPYEMFQSG ANHVQCNTDP FDSEEKDKEY KPHSIPLRQS
200
201
VQPLKFSCYS RRAKRLQPEP EPTEEDIEKN PELKKLQIYG AGPKMIGLGL
250
251
MAKEKTLRKK GSIQPDKEEV TCPATVIVKG EASGFGKVTS AFSDKNLNHN
300
301
FKPCTEMTTQ LRNNHSNTQF MDSYVCRICS RGDEDDRFLL CVGCNDNYHI
350
351
FCLLPPLSEV PKGVWRCPKC ILAECKRPLE AFGFEQATQE YTLQSFGEMA
400
401
DSFKADYFNM PVHMVPTEVV EKEFWRLVSS IEEDVTVEYG ADIHSKEFGS
450
451
GFPVNNSKWT LSPEEKEYAA SGWNLNVMPV LDQSVLCHIN ADISGMKVPW
500
501
LYVGMVFSAF CWHIEDHWSY SINYLHWGEP KTWYGVPSLA AEHLEDVMKT
550
551
LTPELFDSQP DLLHQLVTLM NPNTLMSHGV PVVRTNQCAG EFVITFPRAY
600
601
HSGFNQGYNF AEAVNFCTAD WLPVGRQCIE HYRRLRRYCV FSHEELICKM
650
651
AAFPEKLDLN LAVAVHKEMF IMVQEERRLR KTLLEKGITE AEREAFELLP
700
701
DDERQCIKCK TTCFLSALAC YDCPDGLVCL SHINDLCKCS RSRQYLRYRY
750
751
TLDELPAMLQ KLKIRAESFD NWANKVQAAL EVEDGRKRSF EELRALETEA
800
801
HDRQFPNNDL LQRLKKCLTE AEACISQVLE LVNNSEDRLE TPQLTLTELQ
850
851
ILLKQMCTLP CTIHQIDEVK DVLQQVETYQ IETREALTSL PYSLEILQSL
900
901
MEKGQQLRVE VPEAHQLEEL LEQAQWLDQV KQALAPSGQK HSLVIMKKLL
950
951
VMGTKLASSP SVNKARAELQ ELLTIAERWE EKALFCLDAS QKHSPATLEV
1000
1001
IIREAENIPV YLPNIQSLKE ALTKAQAWIA DVNEIQNGDH YPCLDDLEGL
1050
1051
VAVGRDLPVE LEELKQLENQ VLTAHSWKEK ASKTFLKKNS CYTLLEVLCP
1100
1101
CADAGSVSTK RSRWIEKEMG LYKYDTELLG LSAQDLRDPG SVIMAFKEGE
1150
1151
EKEKEGILHL RHINSTKPSP MSSSINASAT SICICGQVRA GVEALRCDLC
1200
1201
HDWFHGQCVT VPHLLSSLRA SHTSSQLLAW WEWDTKFLCP LCMRSRRPRL
1250
1251
ETILSLLVGL QRLSVRLPEG EALQCLTERA IGWQGRARQA LASENVTALL
1300
1301
KQLAKSRQQL QDELRHEKPP TSHSGLPSEC LTEDSDKDIL KEEEELVLNE
1350
1351
DMLKNSEKIV PKESSCERGE ELLPSLLSQL TGPVLELPEA TRAPLEELMM
1400
1401
EGDLLEVTLD ENHSIWQLLQ AGQNPNLERI HTLLELEKPE DPKNWSEEQT
1450
1451
PERRQRRRQK VVLSRKGEDL TQKELASKRA RSSRIKPKGK QFQEPIHGDN
1500
1501
VLLSHHTEHT NILKGNMNSV QGKDPSPSST FPSLPPLLHL SYFHQQKLQQ
1550
1551
                                                      
1550
 

Show the unformatted sequence.

Checksums:
CRC64:7A71B3E2AD3F4C3B
MD5:288341391005e508223ddbbb084f24ab

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;