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Structure: 5GWK


PDB entry 5gwk: Human topoisomerase IIalpha in complex with DNA and etoposide
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PDB entry 5gwk

Human topoisomerase iialpha in complex with dna and etoposide

Experiment type: X-ray diffraction, resolution 3.15Å
Release date: 2017-11-08
Authors: Wang, Y.R., Wu, C.C., Chan, N.L.
Species: Homo sapiens (Human)


Below is the PDBprint for entry 5gwk.

External database links

Domain organisation

Many structures in the PDB are linked to one or more UniProt protein sequence entries. This section shows the Pfam domains which are found on the UniProt sequence(s) referred to by this structure.

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Sequence mapping

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from PDBe, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the sequences and Pfam domains that correspond to this structure.

PDB UniProt Pfam family
Chain Start End ID Start End
A 456 572 P11388 456 572 Toprim (PF01751)
A 573 711 P11388 573 711 TOPRIM_C (PF16898)
A 713 1172 P11388 713 1172 DNA_topoisoIV (PF00521)
B 456 572 P11388 456 572 Toprim (PF01751)
B 573 711 P11388 573 711 TOPRIM_C (PF16898)
B 713 1172 P11388 713 1172 DNA_topoisoIV (PF00521)

Note: This mapping was provided by the PDBe group.

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