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Structure: 6R6H

Summary

6r6h
PDB entry 6r6h: Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
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PDB entry 6r6h

Structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome

Experiment type: Electron Microscopy, resolution 8.40Å
Release date: 2019-09-04
Authors: Morris, E.P., Faull, S.V., Lau, A.M.C., Politis, A., Beuron, F., Cronin, N.
Species: Homo sapiens (Human)

PDBprint

Below is the PDBprint for entry 6r6h.

External database links

Domain organisation

Many structures in the PDB are linked to one or more UniProt protein sequence entries. This section shows the Pfam domains which are found on the UniProt sequence(s) referred to by this structure.

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Sequence mapping

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from PDBe, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the sequences and Pfam domains that correspond to this structure.

PDB UniProt Pfam family
Chain Start End ID Start End
A 163 345 Q13098 127 309 RPN7 (PF10602)
A 360 464 Q13098 324 428 PCI (PF01399)
B 309 413 P61201 309 413 PCI (PF01399)
C 258 362 Q9UNS2 258 362 PCI (PF01399)
D 264 363 Q9BT78 264 363 PCI (PF01399)
D 365 406 Q9BT78 365 406 CSN4_RPN5_eIF3a (PF18420)
E 50 164 Q92905 50 164 JAB (PF01398)
E 251 329 Q92905 251 329 CSN5_C (PF18323)
F 36 148 Q7L5N1 36 148 JAB (PF01398)
F 194 307 Q7L5N1 194 307 MitMem_reg (PF13012)
G 61 156 Q9H9Q2 61 156 PCI (PF01399)
G 166 214 Q9H9Q2 166 214 CSN7a_helixI (PF18392)
H 31 167 Q99627 31 167 CSN8_PSD8_EIF3K (PF10075)
O 14 644 Q13617 14 644 Cullin (PF00888)
O 675 737 Q13617 675 737 Cullin_Nedd8 (PF10557)
P 4 67 Q15370 4 67 ubiquitin (PF00240)
V 63 144 P40337 63 144 VHL (PF01847)
V 156 204 P40337 156 204 VHL_C (PF17211)

Note: This mapping was provided by the PDBe group.

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