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231  structures 7877  species 4  interactions 267763  sequences 1752  architectures

Clan: APC (CL0062)


APC superfamily Add an annotation

This large superfamily contains a variety of transporters including amino acid permeases that according to TCDB belong to the APC (Amino acid-Polyamine-organoCation) superfamily.

This clan contains 20 families and the total number of domains in the clan is 267763. The clan was built by A Bateman.


This clan contains the following 20 member families:

AA_permease AA_permease_2 AA_permease_C Aa_trans BCCT BenE Branch_AA_trans CstA HCO3_cotransp K_trans MFS_MOT1 Na_Ala_symp Nramp SNF Spore_permease SSF Sulfate_transp Transp_cyt_pur Trp_Tyr_perm Xan_ur_permease

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AA_permease_2 (PF13520) 46333 (17.3%) View
SSF (PF00474) 29439 (11.0%) View
AA_permease (PF00324) 28069 (10.5%) View
Aa_trans (PF01490) 27738 (10.4%) View
Sulfate_transp (PF00916) 23116 (8.6%) View
SNF (PF00209) 21289 (8.0%) View
Xan_ur_permease (PF00860) 20184 (7.5%) View
Transp_cyt_pur (PF02133) 10855 (4.1%) View
HCO3_cotransp (PF00955) 10187 (3.8%) View
Nramp (PF01566) 9687 (3.6%) View
K_trans (PF02705) 7736 (2.9%) View
Na_Ala_symp (PF01235) 6567 (2.5%) View
BCCT (PF02028) 6439 (2.4%) View
CstA (PF02554) 4472 (1.7%) View
AA_permease_C (PF13906) 3869 (1.4%) View
Spore_permease (PF03845) 3799 (1.4%) View
Branch_AA_trans (PF05525) 2350 (0.9%) View
Trp_Tyr_perm (PF03222) 1971 (0.7%) View
MFS_MOT1 (PF16983) 1909 (0.7%) View
BenE (PF03594) 1754 (0.7%) View
Total: 20 Total: 267763 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families
AA_permease_2 AA_permease_2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...