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3643  structures 8689  species 0  interactions 1547654  sequences 28802  architectures

Clan: Beta_propeller (CL0186)

Summary

Beta propeller clan Add an annotation

This large clan contains proteins that contain beta propellers. These are composed of between 6 and 8 repeats. The individual repeats are composed of a four stranded sheet. The clan includes families such as WD40 Pfam:PF00400 where the individual repeats are modeled. The clan also includes families where the entire propeller is modeled such as Pfam:PF02239 usually because the individual repeats are not discernible. These proteins carry out a very wide diversity of functions including catalysis.

This clan contains 88 families and the total number of domains in the clan is 1547654. The clan was built by A Bateman.

Literature references

  1. Murzin AG; , Proteins. 1992;14:191-201.: Structural principles for the propeller assembly of beta-sheets: the preference for seven-fold symmetry. PUBMED:1409568 EPMC:1409568

Members

This clan contains the following 88 member families:

ANAPC4_WD40 APMAP_N Arylesterase Arylsulfotran_2 Arylsulfotrans B_lectin BBS2_Mid Beta_propel Coatomer_WDAD CPSF_A CyRPA Cytochrom_D1 Dpp_8_9_N DPPIV_N DPPIV_rep DUF1513 DUF1668 DUF2415 DUF3748 DUF4221 DUF4933 DUF4934 DUF5046 DUF5050 DUF5122 DUF5128 DUF5711 DUF839 eIF2A FG-GAP FG-GAP_2 FG-GAP_3 Frtz Ge1_WD40 Glu_cyclase_2 Gmad1 GSDH Hyd_WA IKI3 Itfg2 Kelch_1 Kelch_2 Kelch_3 Kelch_4 Kelch_5 Kelch_6 Lactonase Ldl_recept_b LGFP Lgl_C LVIVD Me-amine-dh_H MgpC MRJP Nbas_N Neisseria_PilC NHL nos_propeller nos_propeller_2 Nucleoporin_N Nup160 PALB2_WD40 PD40 Pectate_lyase22 Peptidase_S9_N PHTB1_N Phytase-like PQQ PQQ_2 PQQ_3 RAG2 RCC1 RCC1_2 Reg_prop SBBP SBP56 SdiA-regulated SGL Str_synth TcdB_toxin_midN Tectonin TolB_like VID27 WD40 WD40_2 WD40_3 WD40_4 WD40_like

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
WD40 (PF00400) 832163 (53.8%) View
RCC1 (PF00415) 94045 (6.1%) View
Kelch_1 (PF01344) 93885 (6.1%) View
PD40 (PF07676) 54243 (3.5%) View
Ldl_recept_b (PF00058) 46797 (3.0%) View
FG-GAP_3 (PF13517) 43258 (2.8%) View
PQQ_2 (PF13360) 33722 (2.2%) View
NHL (PF01436) 26184 (1.7%) View
Reg_prop (PF07494) 23220 (1.5%) View
FG-GAP (PF01839) 21314 (1.4%) View
Kelch_4 (PF13418) 20131 (1.3%) View
ANAPC4_WD40 (PF12894) 19758 (1.3%) View
B_lectin (PF01453) 16402 (1.1%) View
RCC1_2 (PF13540) 15348 (1.0%) View
GSDH (PF07995) 14032 (0.9%) View
SGL (PF08450) 12824 (0.8%) View
Kelch_3 (PF13415) 12528 (0.8%) View
DPPIV_N (PF00930) 10685 (0.7%) View
Lactonase (PF10282) 9814 (0.6%) View
Peptidase_S9_N (PF02897) 9551 (0.6%) View
Kelch_6 (PF13964) 7744 (0.5%) View
Kelch_5 (PF13854) 6976 (0.5%) View
CPSF_A (PF03178) 5908 (0.4%) View
DUF839 (PF05787) 5771 (0.4%) View
LVIVD (PF08309) 5707 (0.4%) View
eIF2A (PF08662) 5523 (0.4%) View
DUF5122 (PF17164) 5380 (0.3%) View
Coatomer_WDAD (PF04053) 4853 (0.3%) View
LGFP (PF08310) 4821 (0.3%) View
PQQ (PF01011) 4795 (0.3%) View
FG-GAP_2 (PF14312) 4698 (0.3%) View
WD40_4 (PF16300) 4539 (0.3%) View
Phytase-like (PF13449) 4180 (0.3%) View
WD40_2 (PF19056) 3726 (0.2%) View
Str_synth (PF03088) 3645 (0.2%) View
Kelch_2 (PF07646) 3390 (0.2%) View
Nucleoporin_N (PF08801) 2961 (0.2%) View
Arylsulfotran_2 (PF14269) 2712 (0.2%) View
DUF1668 (PF07893) 2440 (0.2%) View
MRJP (PF03022) 2423 (0.2%) View
Nup160 (PF11715) 2369 (0.2%) View
IKI3 (PF04762) 2360 (0.2%) View
PQQ_3 (PF13570) 2279 (0.1%) View
Tectonin (PF19193) 2050 (0.1%) View
Hyd_WA (PF06462) 2039 (0.1%) View
continued
Pfam family Num. domains Alignment
SBP56 (PF05694) 2016 (0.1%) View
Lgl_C (PF08596) 2002 (0.1%) View
Glu_cyclase_2 (PF05096) 1907 (0.1%) View
Cytochrom_D1 (PF02239) 1859 (0.1%) View
SBBP (PF06739) 1855 (0.1%) View
DUF5128 (PF17170) 1848 (0.1%) View
DUF5050 (PF16472) 1599 (0.1%) View
Gmad1 (PF10647) 1433 (0.1%) View
APMAP_N (PF20067) 1403 (0.1%) View
Neisseria_PilC (PF05567) 1323 (0.1%) View
Ge1_WD40 (PF16529) 1294 (0.1%) View
VID27 (PF08553) 1285 (0.1%) View
Arylsulfotrans (PF05935) 1052 (0.1%) View
Arylesterase (PF01731) 1047 (0.1%) View
Dpp_8_9_N (PF19520) 933 (0.1%) View
DUF2415 (PF10313) 856 (0.1%) View
PHTB1_N (PF14727) 848 (0.1%) View
nos_propeller (PF18764) 842 (0.1%) View
Beta_propel (PF09826) 830 (0.1%) View
DUF1513 (PF07433) 768 (0.0%) View
Itfg2 (PF15907) 699 (0.0%) View
BBS2_Mid (PF14783) 658 (0.0%) View
SdiA-regulated (PF06977) 657 (0.0%) View
WD40_3 (PF15911) 599 (0.0%) View
TcdB_toxin_midN (PF12256) 572 (0.0%) View
Nbas_N (PF15492) 526 (0.0%) View
Frtz (PF11768) 501 (0.0%) View
DUF5711 (PF18975) 473 (0.0%) View
nos_propeller_2 (PF18793) 445 (0.0%) View
Pectate_lyase22 (PF14583) 361 (0.0%) View
DUF4221 (PF13970) 300 (0.0%) View
PALB2_WD40 (PF16756) 296 (0.0%) View
DPPIV_rep (PF18811) 293 (0.0%) View
TolB_like (PF15869) 286 (0.0%) View
Me-amine-dh_H (PF06433) 214 (0.0%) View
RAG2 (PF03089) 209 (0.0%) View
DUF3748 (PF12566) 195 (0.0%) View
WD40_like (PF17005) 57 (0.0%) View
CyRPA (PF18638) 52 (0.0%) View
DUF4934 (PF16288) 35 (0.0%) View
DUF4933 (PF16287) 19 (0.0%) View
MgpC (PF05220) 9 (0.0%) View
DUF5046 (PF16465) 5 (0.0%) View
Total: 88 Total: 1547654
No alignment ℹ
 

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Family relationships

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Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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