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4527  structures 9046  species 0  interactions 605405  sequences 9019  architectures

Clan: AB_hydrolase (CL0028)

Summary

Alpha/Beta hydrolase fold Add an annotation

This catalytic domain is found in a very wide range of enzymes.

This clan contains 73 families and the total number of domains in the clan is 605405. The clan was built by A Bateman.

Literature references

  1. Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag J, Sussman JL, Verschueren KHG, Goldman A; , Protein Eng 1992;5:197-211.: The alpha/beta hydrolase fold PUBMED:1409539 EPMC:1409539

Members

This clan contains the following 73 member families:

3HBOH Abhydro_lipase Abhydrolase_1 Abhydrolase_10 Abhydrolase_2 Abhydrolase_3 Abhydrolase_4 Abhydrolase_5 Abhydrolase_6 Abhydrolase_7 Abhydrolase_8 Abhydrolase_9 Acyl_transf_2 Asp2 AXE1 BAAT_C Chlorophyllase Chlorophyllase2 COesterase Cutinase DLH DUF1057 DUF1350 DUF1400 DUF1749 DUF2048 DUF2235 DUF2920 DUF2974 DUF3089 DUF3141 DUF3530 DUF452 DUF6351 DUF676 DUF726 DUF818 DUF829 DUF900 DUF915 EHN Esterase Esterase_PHB FrsA-like FSH1 Hydrolase_4 LCAT LIDHydrolase LIP Lipase Lipase3_N Lipase_2 Lipase_3 Ndr PAE PAF-AH_p_II Palm_thioest PE-PPE Peptidase_S10 Peptidase_S15 Peptidase_S28 Peptidase_S37 Peptidase_S9 PGAP1 PhaC_N PHB_depo_C PhoPQ_related Say1_Mug180 Ser_hydrolase Tannase Thioesterase UPF0227 VirJ

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Abhydrolase_1 (PF00561) 98862 (16.3%) View
Abhydrolase_6 (PF12697) 74762 (12.3%) View
Abhydrolase_3 (PF07859) 48918 (8.1%) View
Hydrolase_4 (PF12146) 43818 (7.2%) View
Peptidase_S9 (PF00326) 42047 (6.9%) View
COesterase (PF00135) 36236 (6.0%) View
Peptidase_S10 (PF00450) 24713 (4.1%) View
DLH (PF01738) 20731 (3.4%) View
Esterase (PF00756) 19769 (3.3%) View
Lipase_3 (PF01764) 19366 (3.2%) View
Thioesterase (PF00975) 13367 (2.2%) View
Abhydrolase_2 (PF02230) 11589 (1.9%) View
Peptidase_S15 (PF02129) 11192 (1.8%) View
DUF676 (PF05057) 7332 (1.2%) View
Peptidase_S28 (PF05577) 7230 (1.2%) View
Abhydrolase_4 (PF08386) 6424 (1.1%) View
Lipase (PF00151) 6219 (1.0%) View
EHN (PF06441) 6094 (1.0%) View
DUF2235 (PF09994) 5789 (1.0%) View
FSH1 (PF03959) 5465 (0.9%) View
PAF-AH_p_II (PF03403) 5348 (0.9%) View
LCAT (PF02450) 5136 (0.8%) View
Cutinase (PF01083) 4723 (0.8%) View
Tannase (PF07519) 4601 (0.8%) View
Esterase_PHB (PF10503) 4576 (0.8%) View
Ndr (PF03096) 4359 (0.7%) View
PAE (PF03283) 4272 (0.7%) View
Abhydro_lipase (PF04083) 3947 (0.7%) View
LIP (PF03583) 3919 (0.6%) View
Palm_thioest (PF02089) 3757 (0.6%) View
PGAP1 (PF07819) 3506 (0.6%) View
DUF829 (PF05705) 3327 (0.5%) View
DUF726 (PF05277) 3139 (0.5%) View
PhaC_N (PF07167) 2985 (0.5%) View
BAAT_C (PF08840) 2660 (0.4%) View
AXE1 (PF05448) 2579 (0.4%) View
Ser_hydrolase (PF06821) 2572 (0.4%) View
continued
Pfam family Num. domains Alignment
Lipase_2 (PF01674) 2095 (0.3%) View
Abhydrolase_8 (PF06259) 1891 (0.3%) View
PHB_depo_C (PF06850) 1889 (0.3%) View
UPF0227 (PF05728) 1796 (0.3%) View
DUF900 (PF05990) 1782 (0.3%) View
LIDHydrolase (PF10230) 1725 (0.3%) View
FrsA-like (PF06500) 1436 (0.2%) View
Lipase3_N (PF03893) 1385 (0.2%) View
Chlorophyllase2 (PF12740) 1343 (0.2%) View
DUF1749 (PF08538) 1251 (0.2%) View
DUF2048 (PF09752) 1248 (0.2%) View
Abhydrolase_9 (PF10081) 983 (0.2%) View
Abhydrolase_5 (PF12695) 875 (0.1%) View
DUF1350 (PF07082) 840 (0.1%) View
DUF2974 (PF11187) 776 (0.1%) View
PE-PPE (PF08237) 763 (0.1%) View
DUF915 (PF06028) 708 (0.1%) View
Abhydrolase_10 (PF20091) 652 (0.1%) View
DUF3089 (PF11288) 630 (0.1%) View
DUF1400 (PF07176) 626 (0.1%) View
Chlorophyllase (PF07224) 616 (0.1%) View
VirJ (PF06057) 575 (0.1%) View
Peptidase_S37 (PF05576) 567 (0.1%) View
DUF3141 (PF11339) 497 (0.1%) View
PhoPQ_related (PF10142) 416 (0.1%) View
Abhydrolase_7 (PF12715) 402 (0.1%) View
DUF3530 (PF12048) 400 (0.1%) View
3HBOH (PF10605) 371 (0.1%) View
Say1_Mug180 (PF10340) 368 (0.1%) View
DUF6351 (PF19878) 295 (0.0%) View
DUF1057 (PF06342) 291 (0.0%) View
DUF452 (PF04301) 243 (0.0%) View
DUF818 (PF05677) 134 (0.0%) View
Asp2 (PF16929) 120 (0.0%) View
DUF2920 (PF11144) 57 (0.0%) View
Acyl_transf_2 (PF02273) 30 (0.0%) View
Total: 73 Total: 605405
No alignment ℹ
 

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Family relationships

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Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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