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1354  structures 8840  species 0  interactions 205128  sequences 2546  architectures

Clan: Phosphatase (CL0031)


Phosphatase superfamily Add an annotation

This family includes tyrosine and dual specificity phosphatase enzymes.

This clan contains 16 families and the total number of domains in the clan is 205128. The clan was built by A Bateman.

Literature references

  1. Barford D, Das AK, Egloff MP; , Annu Rev Biophys Biomol Struct 1998;27:133-164.: The structure and mechanism of protein phosphatases: insights into catalysis and regulation. PUBMED:9646865 EPMC:9646865


This clan contains the following 16 member families:

CDKN3 DSPc DSPn DUF442 Init_tRNA_PT LMWPc Myotub-related NleF_casp_inhib PTPlike_phytase PTS_IIB Rhodanese Ssu72 Syja_N Y_phosphatase Y_phosphatase2 Y_phosphatase3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Rhodanese (PF00581) 73219 (35.7%) View
Y_phosphatase (PF00102) 38689 (18.9%) View
DSPc (PF00782) 26138 (12.7%) View
LMWPc (PF01451) 17500 (8.5%) View
PTS_IIB (PF02302) 10253 (5.0%) View
Myotub-related (PF06602) 10172 (5.0%) View
Syja_N (PF02383) 9281 (4.5%) View
Y_phosphatase3 (PF13350) 6128 (3.0%) View
Y_phosphatase2 (PF03162) 2828 (1.4%) View
PTPlike_phytase (PF14566) 2695 (1.3%) View
DSPn (PF14671) 2375 (1.2%) View
DUF442 (PF04273) 2228 (1.1%) View
Ssu72 (PF04722) 1711 (0.8%) View
Init_tRNA_PT (PF04179) 997 (0.5%) View
CDKN3 (PF05706) 905 (0.4%) View
NleF_casp_inhib (PF16809) 9 (0.0%) View
Total: 16 Total: 205128 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...