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443  structures 1836  species 0  interactions 71813  sequences 741  architectures

Clan: Cyclin (CL0065)

Summary

Cyclin-like superfamily Add an annotation

This Clan contains cyclins, Transcription factor IIB (TFIIB), and the Retinoblastoma tumour suppressor proteins. These were predicted to be related by sequence [1].

This clan contains 12 families and the total number of domains in the clan is 71813. The clan was built by A Bateman.

Literature references

  1. Gibson TJ, Thompson JD, Blocker A, Kouzarides T; , Nucleic Acids Res 1994;22:946-952.: Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107. PUBMED:8152925 EPMC:8152925
  2. Noble ME, Endicott JA, Brown NR, Johnson LN; , Trends Biochem Sci 1997;22:482-487.: The cyclin box fold: protein recognition in cell-cycle and transcription control. PUBMED:9433129 EPMC:9433129

Members

This clan contains the following 12 member families:

CDK5_activator Cyclin Cyclin_C Cyclin_C_2 Cyclin_N DUF3452 Herp-Cyclin K-cyclin_vir_C RB_A RB_B TFIIB TFIIB_C_1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cyclin_N (PF00134) 30503 (42.5%) View
Cyclin_C (PF02984) 15101 (21.0%) View
TFIIB (PF00382) 11025 (15.4%) View
Cyclin (PF08613) 6967 (9.7%) View
RB_A (PF01858) 2060 (2.9%) View
RB_B (PF01857) 1958 (2.7%) View
DUF3452 (PF11934) 1706 (2.4%) View
Cyclin_C_2 (PF16899) 1655 (2.3%) View
CDK5_activator (PF03261) 814 (1.1%) View
TFIIB_C_1 (PF18542) 17 (0.0%) View
K-cyclin_vir_C (PF09080) 6 (0.0%) View
Herp-Cyclin (PF09241) 1 (0.0%) View
Total: 12 Total: 71813 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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