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444  structures 7794  species 0  interactions 113136  sequences 4524  architectures

Clan: CoA-acyltrans (CL0149)


CoA-dependent acyltransferase superfamily Add an annotation

All characterised families in this clan are involved in CoA-dependent acyltransferase. All families have a characteristic HXXXD motif.

This clan contains 9 families and the total number of domains in the clan is 113136. The clan was built by RD Finn.


This clan contains the following 9 member families:

2-oxoacid_dh AATase Carn_acyltransf CAT Condensation PapA_C Transferase Tri3 WES_acyltransf

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Condensation (PF00668) 49730 (44.0%) View
2-oxoacid_dh (PF00198) 26077 (23.0%) View
Transferase (PF02458) 20669 (18.3%) View
Carn_acyltransf (PF00755) 8440 (7.5%) View
WES_acyltransf (PF03007) 5339 (4.7%) View
AATase (PF07247) 1397 (1.2%) View
CAT (PF00302) 1121 (1.0%) View
Tri3 (PF07428) 209 (0.2%) View
PapA_C (PF16911) 154 (0.1%) View
Total: 9 Total: 113136 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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