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6943  structures 9439  species 0  interactions 1520251  sequences 48885  architectures

Clan: E-set (CL0159)

Summary

Ig-like fold superfamily (E-set) Add an annotation

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

This clan contains 257 families and the total number of domains in the clan is 1520251. The clan was built by RD Finn and A Bateman.

Members

This clan contains the following 257 member families:

A2M A2M_BRD A2M_recep AA9 Adeno_GP19K AlcCBM31 Alpha-amylase_N Alpha_adaptinC2 Alpha_E2_glycop Anth_Ig aRib Arylsulfotran_N ASF1_hist_chap ATG19 BACON BACON_2 BatD BIg21 Big_1 Big_10 Big_11 Big_12 Big_13 Big_14 Big_15 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_3_5 Big_4 Big_5 Big_6 Big_7 Big_8 Big_9 Bile_Hydr_Trans BiPBP_C bMG1 bMG10 bMG3 bMG5 bMG6 BslA BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_4 Cadherin_5 Cadherin_pro CagX Calx-beta Candida_ALS_N CARDB CBM39 CBM_X2 CD45 CelD_N Ceramidse_alk_C CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N ChiW_Ig_like Chlam_OMP6 CHU_C Coatamer_beta_C COP-gamma_platf CopC CshA_repeat Cyc-maltodext_N Cytomega_US3 DBB DsbC DUF11 DUF1410 DUF1425 DUF2271 DUF3244 DUF3458 DUF3501 DUF3823_C DUF3859 DUF4165 DUF4179 DUF4426 DUF4469 DUF4625 DUF4784_N DUF4879 DUF4959 DUF4982 DUF4998 DUF5001 DUF5008 DUF5011 DUF5060 DUF5065 DUF5103 DUF5115 DUF525 DUF5643 DUF6383 DUF6595 DUF916 EB_dh ECD Enterochelin_N EpoR_lig-bind ERAP1_C EstA_Ig_like Expansin_C Filamin FixG_C Flavi_glycop_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 fn3_6 FN3_7 Fn3_assoc fn3_PAP GBS_Bsp-like GlgE_dom_N_S Glucodextran_B Glyco_hydro2_C5 Glyco_hydro_2 Gmad2 GMP_PDE_delta GO-like_E_set GspA_SrpA_N Hanta_G1 He_PIG HECW_N HemeBinding_Shp Hemocyanin_C Herpes_BLLF1 HYR IalB IFNGR1 Ig_GlcNase Ig_mannosidase IL12p40_C Il13Ra_Ig IL17R_fnIII_D1 IL17R_fnIII_D2 IL2RB_N1 IL3Ra_N IL4Ra_N IL6Ra-bind Inhibitor_I42 Inhibitor_I71 InlK_D3 Integrin_alpha2 Interfer-bind Invasin_D3 IRK_C IrmA Iron_transport Kre9_KNH LacZ_4 LEA_2 Lep_receptor_Ig LIFR_D2 LIFR_N Lipase_bact_N LodA_N LPMO_10 LRR_adjacent LTD MALT1_Ig Mannosidase_ig MetallophosC MG1 MG2 MG3 MG4 Mo-co_dimer N_BRCA1_IG Na_K-ATPase NAR2 NDNF NDNF_C NEAT Neocarzinostat Neurexophilin NPCBM_assoc Omp28 PapD_C PBP-Tp47_c Peptidase_C25_C Phlebo_G2_C PhoD_N PKD PKD_2 PKD_3 PKD_4 PKD_5 PKD_6 Por_Secre_tail Pox_vIL-18BP Psg1 PTP_tm Pullulanase_N2 Pur_ac_phosph_N Qn_am_d_aIII Qn_am_d_aIV RabGGT_insert Reeler REJ RET_CLD1 RET_CLD3 RET_CLD4 RGI_lyase RHD_dimer Rho_GDI Rib RibLong SCAB-Ig SKICH SLAM SoxZ SprB SusE SVA SWM_repeat T2SS-T3SS_pil_N Tafi-CsgC TarS_C1 TcA_RBD TcfC TIG TIG_2 TIG_plexin TIG_SUH Tissue_fac Top6b_C TPPII TQ Transglut_C Transglut_N TRAP_beta TraQ_transposon UL16 Velvet WIF Wzt_C Y_Y_Y YBD YscW ZirS_C Zona_pellucida

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
fn3 (PF00041) 422883 (27.8%) View
Cadherin (PF00028) 278836 (18.3%) View
Filamin (PF00630) 60076 (4.0%) View
TIG (PF01833) 40678 (2.7%) View
Calx-beta (PF03160) 31376 (2.1%) View
Cadherin_3 (PF16184) 28446 (1.9%) View
Por_Secre_tail (PF18962) 26784 (1.8%) View
Big_9 (PF17963) 21315 (1.4%) View
Fn3-like (PF14310) 19544 (1.3%) View
PKD_4 (PF18911) 18703 (1.2%) View
Glyco_hydro_2 (PF00703) 16791 (1.1%) View
DUF11 (PF01345) 15955 (1.0%) View
Cadherin_2 (PF08266) 15335 (1.0%) View
ERAP1_C (PF11838) 13601 (0.9%) View
Big_2 (PF02368) 12636 (0.8%) View
Zona_pellucida (PF00100) 12634 (0.8%) View
HYR (PF02494) 12005 (0.8%) View
He_PIG (PF05345) 11334 (0.7%) View
fn3_6 (PF17766) 11167 (0.7%) View
LEA_2 (PF03168) 10110 (0.7%) View
Integrin_alpha2 (PF08441) 9398 (0.6%) View
SprB (PF13573) 9301 (0.6%) View
Alpha_adaptinC2 (PF02883) 9269 (0.6%) View
A2M (PF00207) 9198 (0.6%) View
CHU_C (PF13585) 8879 (0.6%) View
PKD (PF00801) 8597 (0.6%) View
A2M_BRD (PF07703) 8356 (0.5%) View
LTD (PF00932) 8140 (0.5%) View
Pur_ac_phosph_N (PF16656) 8130 (0.5%) View
MG2 (PF01835) 7913 (0.5%) View
Expansin_C (PF01357) 7677 (0.5%) View
Y_Y_Y (PF07495) 7458 (0.5%) View
Big_13 (PF19077) 7260 (0.5%) View
IRK_C (PF17655) 7194 (0.5%) View
AA9 (PF03443) 6553 (0.4%) View
Big_5 (PF13205) 6274 (0.4%) View
Transglut_C (PF00927) 6141 (0.4%) View
A2M_recep (PF07677) 6015 (0.4%) View
Mo-co_dimer (PF03404) 5496 (0.4%) View
RHD_dimer (PF16179) 5487 (0.4%) View
MG3 (PF17791) 5393 (0.4%) View
DsbC (PF11412) 5208 (0.3%) View
Velvet (PF11754) 4784 (0.3%) View
Big_7 (PF17957) 4724 (0.3%) View
Big_3_5 (PF16640) 4575 (0.3%) View
GO-like_E_set (PF09118) 4476 (0.3%) View
DUF525 (PF04379) 4444 (0.3%) View
PhoD_N (PF16655) 4398 (0.3%) View
LPMO_10 (PF03067) 4368 (0.3%) View
LacZ_4 (PF16353) 4160 (0.3%) View
TIG_plexin (PF17960) 4081 (0.3%) View
MG4 (PF17789) 4070 (0.3%) View
CopC (PF04234) 3973 (0.3%) View
CARDB (PF07705) 3929 (0.3%) View
Big_6 (PF17936) 3913 (0.3%) View
Transglut_N (PF00868) 3908 (0.3%) View
Cadherin_4 (PF17803) 3877 (0.3%) View
Kre9_KNH (PF10342) 3863 (0.3%) View
Tissue_fac (PF01108) 3844 (0.3%) View
CHB_HEX_C_1 (PF13290) 3841 (0.3%) View
Big_10 (PF17964) 3550 (0.2%) View
Interfer-bind (PF09294) 3476 (0.2%) View
TIG_2 (PF18020) 3439 (0.2%) View
FlgD_ig (PF13860) 3344 (0.2%) View
DUF4982 (PF16355) 3297 (0.2%) View
BatD (PF13584) 3284 (0.2%) View
Reeler (PF02014) 3236 (0.2%) View
bMG10 (PF17973) 3139 (0.2%) View
DUF3458 (PF11940) 3125 (0.2%) View
Glyco_hydro2_C5 (PF18565) 3115 (0.2%) View
Cadherin-like (PF12733) 3115 (0.2%) View
Na_K-ATPase (PF00287) 3105 (0.2%) View
YBD (PF17725) 3035 (0.2%) View
Rho_GDI (PF02115) 3030 (0.2%) View
FixG_C (PF11614) 3023 (0.2%) View
SKICH (PF17751) 2987 (0.2%) View
Neurexophilin (PF06312) 2876 (0.2%) View
N_BRCA1_IG (PF16158) 2829 (0.2%) View
DUF5011 (PF16403) 2812 (0.2%) View
Mannosidase_ig (PF17786) 2736 (0.2%) View
T2SS-T3SS_pil_N (PF13629) 2668 (0.2%) View
Cadherin_pro (PF08758) 2621 (0.2%) View
Big_12 (PF19078) 2605 (0.2%) View
IalB (PF06776) 2586 (0.2%) View
REJ (PF02010) 2391 (0.2%) View
COP-gamma_platf (PF08752) 2362 (0.2%) View
Ceramidse_alk_C (PF17048) 2319 (0.2%) View
Cadherin_5 (PF17892) 2313 (0.2%) View
IL6Ra-bind (PF09240) 2310 (0.2%) View
Ig_mannosidase (PF17753) 2273 (0.1%) View
CagX (PF03524) 2251 (0.1%) View
EpoR_lig-bind (PF09067) 2236 (0.1%) View
GlgE_dom_N_S (PF11896) 2214 (0.1%) View
ASF1_hist_chap (PF04729) 2181 (0.1%) View
Bile_Hydr_Trans (PF04775) 2133 (0.1%) View
NPCBM_assoc (PF10633) 2106 (0.1%) View
fn3_5 (PF06280) 2068 (0.1%) View
BiPBP_C (PF06832) 2045 (0.1%) View
bMG3 (PF11974) 2044 (0.1%) View
Coatamer_beta_C (PF07718) 1992 (0.1%) View
DUF6595 (PF20238) 1971 (0.1%) View
MG1 (PF17790) 1932 (0.1%) View
Wzt_C (PF14524) 1884 (0.1%) View
Big_4 (PF07532) 1874 (0.1%) View
GMP_PDE_delta (PF05351) 1861 (0.1%) View
CelD_N (PF02927) 1805 (0.1%) View
Fn3_assoc (PF13287) 1781 (0.1%) View
bMG5 (PF17972) 1707 (0.1%) View
Lep_receptor_Ig (PF06328) 1683 (0.1%) View
TIG_SUH (PF20144) 1676 (0.1%) View
PTP_tm (PF18861) 1650 (0.1%) View
SoxZ (PF08770) 1588 (0.1%) View
bMG6 (PF17962) 1576 (0.1%) View
Anth_Ig (PF05587) 1545 (0.1%) View
BACON_2 (PF19190) 1541 (0.1%) View
Big_1 (PF02369) 1393 (0.1%) View
TPPII (PF12580) 1357 (0.1%) View
DUF4179 (PF13786) 1333 (0.1%) View
BACON (PF13004) 1281 (0.1%) View
CshA_repeat (PF19076) 1241 (0.1%) View
fn3_PAP (PF17808) 1235 (0.1%) View
WIF (PF02019) 1229 (0.1%) View
CBM_X2 (PF03442) 1222 (0.1%) View
PKD_6 (PF19408) 1220 (0.1%) View
Ig_GlcNase (PF18368) 1216 (0.1%) View
TRAP_beta (PF05753) 1213 (0.1%) View
PKD_5 (PF19406) 1191 (0.1%) View
RGI_lyase (PF18370) 1182 (0.1%) View
PapD_C (PF02753) 1169 (0.1%) View
continued
Pfam family Num. domains Alignment
Alpha-amylase_N (PF02903) 1167 (0.1%) View
Pullulanase_N2 (PF17967) 1147 (0.1%) View
DUF2271 (PF10029) 1128 (0.1%) View
ECD (PF18432) 1093 (0.1%) View
HECW_N (PF16562) 1091 (0.1%) View
Big_3 (PF07523) 1091 (0.1%) View
Glucodextran_B (PF09136) 1076 (0.1%) View
SusE (PF14292) 1071 (0.1%) View
Hemocyanin_C (PF03723) 1027 (0.1%) View
DBB (PF14545) 947 (0.1%) View
DUF5060 (PF16586) 941 (0.1%) View
TQ (PF18202) 940 (0.1%) View
Invasin_D3 (PF09134) 920 (0.1%) View
DUF916 (PF06030) 915 (0.1%) View
fn3_4 (PF16794) 887 (0.1%) View
YscW (PF09619) 861 (0.1%) View
Inhibitor_I42 (PF09394) 810 (0.1%) View
DUF5103 (PF17116) 803 (0.1%) View
NEAT (PF05031) 801 (0.1%) View
Cyc-maltodext_N (PF09087) 770 (0.1%) View
EB_dh (PF09459) 767 (0.1%) View
fn3_2 (PF16893) 754 (0.0%) View
MALT1_Ig (PF18703) 741 (0.0%) View
Big_8 (PF17961) 725 (0.0%) View
SWM_repeat (PF13753) 711 (0.0%) View
MetallophosC (PF16370) 708 (0.0%) View
GBS_Bsp-like (PF08481) 707 (0.0%) View
Rib (PF08428) 697 (0.0%) View
SCAB-Ig (PF16709) 671 (0.0%) View
LIFR_D2 (PF17971) 656 (0.0%) View
IL17R_fnIII_D1 (PF16556) 645 (0.0%) View
DUF5643 (PF18705) 628 (0.0%) View
NDNF_C (PF19433) 624 (0.0%) View
RibLong (PF18957) 616 (0.0%) View
NDNF (PF10179) 599 (0.0%) View
Iron_transport (PF10634) 587 (0.0%) View
Gmad2 (PF10648) 559 (0.0%) View
IL17R_fnIII_D2 (PF16578) 534 (0.0%) View
DUF4426 (PF14467) 532 (0.0%) View
CHB_HEX_C (PF03174) 510 (0.0%) View
PKD_2 (PF16407) 495 (0.0%) View
Psg1 (PF14610) 491 (0.0%) View
IL12p40_C (PF10420) 483 (0.0%) View
Arylsulfotran_N (PF17425) 479 (0.0%) View
Big_3_2 (PF12245) 465 (0.0%) View
Enterochelin_N (PF11806) 459 (0.0%) View
BsuPI (PF12690) 429 (0.0%) View
DUF4959 (PF16323) 421 (0.0%) View
CBM39 (PF15886) 408 (0.0%) View
DUF4625 (PF15418) 399 (0.0%) View
DUF4998 (PF16389) 392 (0.0%) View
RET_CLD3 (PF17812) 389 (0.0%) View
Big_14 (PF20251) 386 (0.0%) View
RET_CLD4 (PF17813) 386 (0.0%) View
RET_CLD1 (PF17756) 382 (0.0%) View
NAR2 (PF16974) 379 (0.0%) View
DUF1425 (PF07233) 375 (0.0%) View
DUF3501 (PF12007) 373 (0.0%) View
LodA_N (PF17990) 367 (0.0%) View
Omp28 (PF11551) 358 (0.0%) View
Big_15 (PF20622) 344 (0.0%) View
IL3Ra_N (PF18611) 343 (0.0%) View
TraQ_transposon (PF12988) 343 (0.0%) View
IL4Ra_N (PF09238) 331 (0.0%) View
EstA_Ig_like (PF18435) 325 (0.0%) View
IL2RB_N1 (PF18707) 321 (0.0%) View
DUF3823_C (PF18003) 317 (0.0%) View
DUF3859 (PF12975) 308 (0.0%) View
RabGGT_insert (PF07711) 305 (0.0%) View
ChitinaseA_N (PF08329) 275 (0.0%) View
aRib (PF18938) 270 (0.0%) View
Lipase_bact_N (PF12262) 258 (0.0%) View
Big_11 (PF18200) 257 (0.0%) View
DUF4469 (PF14734) 257 (0.0%) View
CD45 (PF12567) 251 (0.0%) View
DUF6383 (PF19910) 249 (0.0%) View
bMG1 (PF17970) 221 (0.0%) View
FN3_7 (PF18447) 220 (0.0%) View
PKD_3 (PF16820) 212 (0.0%) View
Candida_ALS_N (PF11766) 202 (0.0%) View
LIFR_N (PF18207) 198 (0.0%) View
Big_3_3 (PF13750) 179 (0.0%) View
TcfC (PF16967) 165 (0.0%) View
Il13Ra_Ig (PF18001) 159 (0.0%) View
IFNGR1 (PF07140) 159 (0.0%) View
InlK_D3 (PF18981) 149 (0.0%) View
Neocarzinostat (PF00960) 148 (0.0%) View
SLAM (PF06214) 147 (0.0%) View
Top6b_C (PF18000) 146 (0.0%) View
DUF3244 (PF11589) 140 (0.0%) View
Qn_am_d_aIII (PF09099) 137 (0.0%) View
Qn_am_d_aIV (PF09100) 133 (0.0%) View
SVA (PF05326) 126 (0.0%) View
Phlebo_G2_C (PF19019) 102 (0.0%) View
LRR_adjacent (PF08191) 99 (0.0%) View
DUF5001 (PF16392) 90 (0.0%) View
DUF5008 (PF16400) 87 (0.0%) View
HemeBinding_Shp (PF11545) 79 (0.0%) View
Herpes_BLLF1 (PF05109) 79 (0.0%) View
DUF4879 (PF16219) 78 (0.0%) View
DUF1410 (PF07198) 67 (0.0%) View
BIg21 (PF05688) 65 (0.0%) View
TarS_C1 (PF18674) 56 (0.0%) View
Tafi-CsgC (PF10610) 56 (0.0%) View
DUF5115 (PF17142) 47 (0.0%) View
Peptidase_C25_C (PF03785) 42 (0.0%) View
ATG19 (PF12744) 32 (0.0%) View
BslA (PF17735) 29 (0.0%) View
PBP-Tp47_c (PF14888) 27 (0.0%) View
GspA_SrpA_N (PF20164) 23 (0.0%) View
Inhibitor_I71 (PF12628) 23 (0.0%) View
ChiW_Ig_like (PF18683) 22 (0.0%) View
IrmA (PF18673) 22 (0.0%) View
TcA_RBD (PF18518) 19 (0.0%) View
DUF4784_N (PF20264) 16 (0.0%) View
DUF4165 (PF13752) 16 (0.0%) View
Big_3_4 (PF13754) 15 (0.0%) View
Cytomega_US3 (PF05963) 15 (0.0%) View
AlcCBM31 (PF11606) 15 (0.0%) View
Pox_vIL-18BP (PF05566) 13 (0.0%) View
Adeno_GP19K (PF04881) 13 (0.0%) View
Hanta_G1 (PF01567) 11 (0.0%) View
ZirS_C (PF16583) 5 (0.0%) View
Alpha_E2_glycop (PF00943) 5 (0.0%) View
Chlam_OMP6 (PF03504) 4 (0.0%) View
DUF5065 (PF16723) 4 (0.0%) View
UL16 (PF17622) 3 (0.0%) View
Flavi_glycop_C (PF02832) 3 (0.0%) View
Total: 257 Total: 1520251
No alignment ℹ
 

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Family relationships

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Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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