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6475  structures 9213  species 0  interactions 1195600  sequences 45331  architectures

Clan: E-set (CL0159)

Summary

Ig-like fold superfamily (E-set) Add an annotation

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

This clan contains 238 families and the total number of domains in the clan is 1195600. The clan was built by RD Finn and A Bateman.

Members

This clan contains the following 238 member families:

A2M A2M_BRD A2M_recep AA9 Adeno_GP19K AlcCBM31 Alpha-amylase_N Alpha_adaptinC2 Alpha_E2_glycop Anth_Ig Arch_flagellin aRib Arylsulfotran_N ASF1_hist_chap ATG19 BACON BACON_2 BatD BIg21 Big_1 Big_10 Big_11 Big_12 Big_13 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_3_5 Big_4 Big_5 Big_6 Big_7 Big_8 Big_9 Bile_Hydr_Trans BiPBP_C bMG1 bMG10 bMG3 bMG5 bMG6 BslA BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_4 Cadherin_5 Cadherin_pro CagX Calx-beta Candida_ALS_N CARDB CBM39 CBM_X2 CD45 CelD_N Ceramidse_alk_C CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N ChiW_Ig_like Chlam_OMP6 CHU_C Coatamer_beta_C COP-gamma_platf CopC CshA_repeat Cyc-maltodext_N Cytomega_US3 DsbC DUF11 DUF1410 DUF1425 DUF1929 DUF2271 DUF3244 DUF3327 DUF3416 DUF3458 DUF3501 DUF3823_C DUF3859 DUF4165 DUF4179 DUF4426 DUF4469 DUF4625 DUF4879 DUF4959 DUF4981 DUF4982 DUF4998 DUF5001 DUF5008 DUF5011 DUF5065 DUF5115 DUF525 DUF5643 DUF6383 DUF916 EB_dh ECD EpoR_lig-bind ERAP1_C EstA_Ig_like Expansin_C Filamin FixG_C Flavi_glycop_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 fn3_6 FN3_7 Fn3_assoc fn3_PAP GBS_Bsp-like Glucodextran_B Glyco_hydro2_C5 Glyco_hydro_2 Gmad2 GMP_PDE_delta GPI-anchored Hanta_G1 He_PIG HECW_N HemeBinding_Shp Hemocyanin_C Herpes_BLLF1 HYR IFNGR1 Ig_GlcNase Ig_mannosidase IL12p40_C Il13Ra_Ig IL17R_fnIII_D1 IL17R_fnIII_D2 IL2RB_N1 IL3Ra_N IL4Ra_N IL6Ra-bind Inhibitor_I42 Inhibitor_I71 InlK_D3 Integrin_alpha2 Interfer-bind Invasin_D3 IRK_C IrmA Iron_transport LEA_2 Lep_receptor_Ig LIFR_N Lipase_bact_N LPMO_10 LRR_adjacent LTD Mannosidase_ig MetallophosC MG1 MG2 MG3 MG4 Mo-co_dimer N_BRCA1_IG Na_K-ATPase NEAT Neocarzinostat Neurexophilin NPCBM_assoc PapD_C PBP-Tp47_c Peptidase_C25_C Phlebo_G2_C PhoD_N PKD PKD_2 PKD_3 PKD_4 PKD_5 PKD_6 Por_Secre_tail Pox_vIL-18BP Psg1 PTP_tm Pur_ac_phosph_N Qn_am_d_aII Qn_am_d_aIII RabGGT_insert Reeler REJ RET_CLD1 RET_CLD3 RET_CLD4 RGI_lyase RHD_dimer Rho_GDI Rib RibLong SCAB-Ig SKICH SLAM SoxZ SprB SusE SVA SWM_repeat T2SS-T3SS_pil_N Tafi-CsgC TarS_C1 TcA_RBD TcfC TIG TIG_2 TIG_plexin TIG_SUH Tissue_fac Top6b_C Transglut_C Transglut_N TRAP_beta TraQ_transposon UL16 Velvet WIF Wzt_C Y_Y_Y YBD ZirS_C Zona_pellucida

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
fn3 (PF00041) 280959 (23.5%) View
Cadherin (PF00028) 212635 (17.8%) View
Filamin (PF00630) 43921 (3.7%) View
TIG (PF01833) 33063 (2.8%) View
Calx-beta (PF03160) 26464 (2.2%) View
Por_Secre_tail (PF18962) 25549 (2.1%) View
Cadherin_3 (PF16184) 22316 (1.9%) View
Big_9 (PF17963) 20346 (1.7%) View
Fn3-like (PF14310) 18946 (1.6%) View
PKD_4 (PF18911) 17638 (1.5%) View
Glyco_hydro_2 (PF00703) 16430 (1.4%) View
DUF11 (PF01345) 15605 (1.3%) View
Big_2 (PF02368) 12068 (1.0%) View
ERAP1_C (PF11838) 11798 (1.0%) View
Cadherin_2 (PF08266) 11532 (1.0%) View
He_PIG (PF05345) 10872 (0.9%) View
fn3_6 (PF17766) 10326 (0.9%) View
Zona_pellucida (PF00100) 9909 (0.8%) View
LEA_2 (PF03168) 9283 (0.8%) View
SprB (PF13573) 8750 (0.7%) View
CHU_C (PF13585) 8422 (0.7%) View
A2M (PF00207) 7759 (0.6%) View
Alpha_adaptinC2 (PF02883) 7720 (0.6%) View
Pur_ac_phosph_N (PF16656) 7620 (0.6%) View
Integrin_alpha2 (PF08441) 7455 (0.6%) View
LTD (PF00932) 7411 (0.6%) View
Expansin_C (PF01357) 7178 (0.6%) View
Y_Y_Y (PF07495) 7176 (0.6%) View
A2M_BRD (PF07703) 6989 (0.6%) View
PKD (PF00801) 6697 (0.6%) View
Big_13 (PF19077) 6654 (0.6%) View
MG2 (PF01835) 6638 (0.6%) View
AA9 (PF03443) 6364 (0.5%) View
HYR (PF02494) 6105 (0.5%) View
Big_5 (PF13205) 6018 (0.5%) View
IRK_C (PF17655) 5906 (0.5%) View
Mo-co_dimer (PF03404) 5219 (0.4%) View
DsbC (PF11412) 5057 (0.4%) View
Transglut_C (PF00927) 4723 (0.4%) View
Velvet (PF11754) 4697 (0.4%) View
A2M_recep (PF07677) 4647 (0.4%) View
Big_7 (PF17957) 4495 (0.4%) View
DUF1929 (PF09118) 4257 (0.4%) View
Big_3_5 (PF16640) 4243 (0.4%) View
PhoD_N (PF16655) 4239 (0.4%) View
LPMO_10 (PF03067) 4173 (0.3%) View
MG3 (PF17791) 4131 (0.3%) View
DUF525 (PF04379) 4104 (0.3%) View
RHD_dimer (PF16179) 4075 (0.3%) View
DUF4981 (PF16353) 4063 (0.3%) View
CopC (PF04234) 3825 (0.3%) View
CARDB (PF07705) 3796 (0.3%) View
Big_6 (PF17936) 3760 (0.3%) View
CHB_HEX_C_1 (PF13290) 3722 (0.3%) View
GPI-anchored (PF10342) 3669 (0.3%) View
Cadherin_4 (PF17803) 3639 (0.3%) View
Big_10 (PF17964) 3449 (0.3%) View
DUF4982 (PF16355) 3219 (0.3%) View
FlgD_ig (PF13860) 3202 (0.3%) View
MG4 (PF17789) 3197 (0.3%) View
BatD (PF13584) 3164 (0.3%) View
Cadherin-like (PF12733) 3071 (0.3%) View
Transglut_N (PF00868) 3044 (0.3%) View
Tissue_fac (PF01108) 3044 (0.3%) View
Glyco_hydro2_C5 (PF18565) 3031 (0.3%) View
bMG10 (PF17973) 3023 (0.3%) View
DUF3458 (PF11940) 2965 (0.2%) View
TIG_plexin (PF17960) 2962 (0.2%) View
FixG_C (PF11614) 2874 (0.2%) View
Interfer-bind (PF09294) 2801 (0.2%) View
Rho_GDI (PF02115) 2719 (0.2%) View
Mannosidase_ig (PF17786) 2573 (0.2%) View
T2SS-T3SS_pil_N (PF13629) 2567 (0.2%) View
Na_K-ATPase (PF00287) 2549 (0.2%) View
N_BRCA1_IG (PF16158) 2543 (0.2%) View
TIG_2 (PF18020) 2516 (0.2%) View
Reeler (PF02014) 2489 (0.2%) View
DUF5011 (PF16403) 2487 (0.2%) View
Big_12 (PF19078) 2448 (0.2%) View
Neurexophilin (PF06312) 2323 (0.2%) View
SKICH (PF17751) 2295 (0.2%) View
YBD (PF17725) 2285 (0.2%) View
Cadherin_5 (PF17892) 2173 (0.2%) View
COP-gamma_platf (PF08752) 2154 (0.2%) View
Ceramidse_alk_C (PF17048) 2146 (0.2%) View
DUF3416 (PF11896) 2135 (0.2%) View
CagX (PF03524) 2133 (0.2%) View
Ig_mannosidase (PF17753) 2094 (0.2%) View
Cadherin_pro (PF08758) 2081 (0.2%) View
ASF1_hist_chap (PF04729) 2039 (0.2%) View
fn3_5 (PF06280) 2025 (0.2%) View
NPCBM_assoc (PF10633) 2007 (0.2%) View
bMG3 (PF11974) 1962 (0.2%) View
BiPBP_C (PF06832) 1958 (0.2%) View
IL6Ra-bind (PF09240) 1909 (0.2%) View
REJ (PF02010) 1877 (0.2%) View
Coatamer_beta_C (PF07718) 1868 (0.2%) View
Bile_Hydr_Trans (PF04775) 1814 (0.2%) View
Wzt_C (PF14524) 1803 (0.2%) View
Big_4 (PF07532) 1798 (0.2%) View
CelD_N (PF02927) 1751 (0.1%) View
EpoR_lig-bind (PF09067) 1749 (0.1%) View
Fn3_assoc (PF13287) 1685 (0.1%) View
bMG5 (PF17972) 1647 (0.1%) View
GMP_PDE_delta (PF05351) 1558 (0.1%) View
SoxZ (PF08770) 1539 (0.1%) View
bMG6 (PF17962) 1524 (0.1%) View
BACON_2 (PF19190) 1514 (0.1%) View
MG1 (PF17790) 1450 (0.1%) View
Big_1 (PF02369) 1414 (0.1%) View
TIG_SUH (PF20144) 1362 (0.1%) View
Lep_receptor_Ig (PF06328) 1317 (0.1%) View
BACON (PF13004) 1304 (0.1%) View
DUF4179 (PF13786) 1281 (0.1%) View
PTP_tm (PF18861) 1228 (0.1%) View
CshA_repeat (PF19076) 1208 (0.1%) View
Anth_Ig (PF05587) 1190 (0.1%) View
PKD_5 (PF19406) 1182 (0.1%) View
PKD_6 (PF19408) 1178 (0.1%) View
Ig_GlcNase (PF18368) 1178 (0.1%) View
continued
Pfam family Num. domains Alignment
PapD_C (PF02753) 1161 (0.1%) View
Alpha-amylase_N (PF02903) 1154 (0.1%) View
fn3_PAP (PF17808) 1151 (0.1%) View
CBM_X2 (PF03442) 1150 (0.1%) View
RGI_lyase (PF18370) 1135 (0.1%) View
DUF2271 (PF10029) 1079 (0.1%) View
TRAP_beta (PF05753) 1077 (0.1%) View
Big_3 (PF07523) 1056 (0.1%) View
SusE (PF14292) 1050 (0.1%) View
Glucodextran_B (PF09136) 1039 (0.1%) View
WIF (PF02019) 944 (0.1%) View
DUF916 (PF06030) 884 (0.1%) View
ECD (PF18432) 873 (0.1%) View
Hemocyanin_C (PF03723) 814 (0.1%) View
HECW_N (PF16562) 813 (0.1%) View
NEAT (PF05031) 800 (0.1%) View
Invasin_D3 (PF09134) 783 (0.1%) View
Inhibitor_I42 (PF09394) 778 (0.1%) View
Cyc-maltodext_N (PF09087) 747 (0.1%) View
fn3_2 (PF16893) 740 (0.1%) View
EB_dh (PF09459) 724 (0.1%) View
Big_8 (PF17961) 703 (0.1%) View
Rib (PF08428) 703 (0.1%) View
MetallophosC (PF16370) 690 (0.1%) View
SWM_repeat (PF13753) 688 (0.1%) View
GBS_Bsp-like (PF08481) 667 (0.1%) View
Arch_flagellin (PF01917) 659 (0.1%) View
fn3_4 (PF16794) 646 (0.1%) View
SCAB-Ig (PF16709) 622 (0.1%) View
RibLong (PF18957) 613 (0.1%) View
DUF5643 (PF18705) 610 (0.1%) View
Iron_transport (PF10634) 566 (0.0%) View
Gmad2 (PF10648) 523 (0.0%) View
DUF4426 (PF14467) 514 (0.0%) View
IL17R_fnIII_D1 (PF16556) 492 (0.0%) View
CHB_HEX_C (PF03174) 487 (0.0%) View
PKD_2 (PF16407) 483 (0.0%) View
Psg1 (PF14610) 481 (0.0%) View
Arylsulfotran_N (PF17425) 453 (0.0%) View
DUF3327 (PF11806) 439 (0.0%) View
Big_3_2 (PF12245) 439 (0.0%) View
IL17R_fnIII_D2 (PF16578) 414 (0.0%) View
BsuPI (PF12690) 411 (0.0%) View
DUF4959 (PF16323) 410 (0.0%) View
IL12p40_C (PF10420) 393 (0.0%) View
DUF4998 (PF16389) 381 (0.0%) View
DUF4625 (PF15418) 376 (0.0%) View
DUF1425 (PF07233) 359 (0.0%) View
DUF3501 (PF12007) 353 (0.0%) View
TraQ_transposon (PF12988) 335 (0.0%) View
CBM39 (PF15886) 317 (0.0%) View
EstA_Ig_like (PF18435) 314 (0.0%) View
DUF3823_C (PF18003) 310 (0.0%) View
RET_CLD3 (PF17812) 298 (0.0%) View
DUF3859 (PF12975) 297 (0.0%) View
RET_CLD4 (PF17813) 294 (0.0%) View
RET_CLD1 (PF17756) 293 (0.0%) View
IL3Ra_N (PF18611) 271 (0.0%) View
ChitinaseA_N (PF08329) 265 (0.0%) View
aRib (PF18938) 262 (0.0%) View
IL4Ra_N (PF09238) 262 (0.0%) View
IL2RB_N1 (PF18707) 261 (0.0%) View
Lipase_bact_N (PF12262) 251 (0.0%) View
DUF6383 (PF19910) 247 (0.0%) View
RabGGT_insert (PF07711) 243 (0.0%) View
DUF4469 (PF14734) 242 (0.0%) View
Big_11 (PF18200) 225 (0.0%) View
bMG1 (PF17970) 213 (0.0%) View
PKD_3 (PF16820) 208 (0.0%) View
CD45 (PF12567) 198 (0.0%) View
FN3_7 (PF18447) 191 (0.0%) View
Candida_ALS_N (PF11766) 190 (0.0%) View
Big_3_3 (PF13750) 168 (0.0%) View
LIFR_N (PF18207) 158 (0.0%) View
TcfC (PF16967) 157 (0.0%) View
Neocarzinostat (PF00960) 143 (0.0%) View
Top6b_C (PF18000) 140 (0.0%) View
InlK_D3 (PF18981) 138 (0.0%) View
DUF3244 (PF11589) 132 (0.0%) View
IFNGR1 (PF07140) 131 (0.0%) View
Il13Ra_Ig (PF18001) 130 (0.0%) View
Qn_am_d_aIII (PF09099) 130 (0.0%) View
SLAM (PF06214) 127 (0.0%) View
Qn_am_d_aII (PF14930) 124 (0.0%) View
SVA (PF05326) 105 (0.0%) View
LRR_adjacent (PF08191) 98 (0.0%) View
Phlebo_G2_C (PF19019) 91 (0.0%) View
DUF5008 (PF16400) 83 (0.0%) View
DUF5001 (PF16392) 83 (0.0%) View
Herpes_BLLF1 (PF05109) 72 (0.0%) View
DUF4879 (PF16219) 69 (0.0%) View
DUF1410 (PF07198) 68 (0.0%) View
BIg21 (PF05688) 67 (0.0%) View
HemeBinding_Shp (PF11545) 61 (0.0%) View
TarS_C1 (PF18674) 54 (0.0%) View
Tafi-CsgC (PF10610) 53 (0.0%) View
DUF5115 (PF17142) 45 (0.0%) View
Peptidase_C25_C (PF03785) 41 (0.0%) View
ATG19 (PF12744) 30 (0.0%) View
BslA (PF17735) 28 (0.0%) View
PBP-Tp47_c (PF14888) 26 (0.0%) View
ChiW_Ig_like (PF18683) 25 (0.0%) View
Inhibitor_I71 (PF12628) 23 (0.0%) View
IrmA (PF18673) 21 (0.0%) View
TcA_RBD (PF18518) 20 (0.0%) View
Cytomega_US3 (PF05963) 15 (0.0%) View
AlcCBM31 (PF11606) 15 (0.0%) View
Big_3_4 (PF13754) 14 (0.0%) View
Adeno_GP19K (PF04881) 14 (0.0%) View
Pox_vIL-18BP (PF05566) 11 (0.0%) View
DUF4165 (PF13752) 11 (0.0%) View
Hanta_G1 (PF01567) 9 (0.0%) View
Chlam_OMP6 (PF03504) 5 (0.0%) View
ZirS_C (PF16583) 5 (0.0%) View
Alpha_E2_glycop (PF00943) 5 (0.0%) View
UL16 (PF17622) 4 (0.0%) View
DUF5065 (PF16723) 3 (0.0%) View
Flavi_glycop_C (PF02832) 3 (0.0%) View
Total: 238 Total: 1195600
No alignment ℹ
 

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Family relationships

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Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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