Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
161  structures 3355  species 0  interactions 29672  sequences 2120  architectures

Clan: STIR (CL0173)


STIR superfamily Add an annotation

Both members of this clan are thought to be involved in TOLL/IL1R-like pathways, by mediating protein-protein interactions between pathway components. The N-termini of SEFIR and TIR domains are similar, but the domains are more divergent towards the C-terminus [1].

This clan contains 6 families and the total number of domains in the clan is 29672. The clan was built by M Fenech.

Literature references

  1. Novatchkova M, Leibbrandt A, Werzowa J, Neubuser A, Eisenhaber F; , Trends Biochem Sci 2003;28:226-229.: The STIR-domain superfamily in signal transduction, development and immunity. PUBMED:12765832 EPMC:12765832


This clan contains the following 6 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TIR (PF01582) 16500 (55.6%) View
TIR_2 (PF13676) 8797 (29.6%) View
SEFIR (PF08357) 2221 (7.5%) View
DUF1863 (PF08937) 1023 (3.4%) View
TIR-like (PF10137) 628 (2.1%) View
TIR_3 (PF18567) 503 (1.7%) View
Total: 6 Total: 29672 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...