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2457  structures 4226  species 0  interactions 315258  sequences 9133  architectures

Clan: EF_hand (CL0220)


EF-hand like superfamily Add an annotation

The EF hand is a calcium binding domain found in a wide variety of proteins [1].

This clan contains 31 families and the total number of domains in the clan is 315258. The clan was built by A Bateman.

Literature references

  1. Yap KL, Ames JB, Swindells MB, Ikura M; , Proteins. 1999;37:499-507.: Diversity of conformational states and changes within the EF-hand protein superfamily. PUBMED:10591109 EPMC:10591109


This clan contains the following 31 member families:

Ca_chan_IQ Caleosin Cbl_N2 Cullin_binding DAG_kinase_N Dockerin_1 EF-hand_1 EF-hand_10 EF-hand_11 EF-hand_12 EF-hand_13 EF-hand_14 EF-hand_2 EF-hand_3 EF-hand_4 EF-hand_5 EF-hand_6 EF-hand_7 EF-hand_8 EF-hand_9 EF-hand_like EF_assoc_2 EFhand_Ca_insen Internalin_N IQ IQCJ-SCHIP1 NADPH_Ox p25-alpha S_100 SPARC_Ca_bdg WEF-hand

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EF-hand_7 (PF13499) 91636 (29.1%) View
IQ (PF00612) 82891 (26.3%) View
EF-hand_5 (PF13202) 33086 (10.5%) View
EF-hand_8 (PF13833) 21034 (6.7%) View
EF-hand_4 (PF12763) 14263 (4.5%) View
EF-hand_1 (PF00036) 10997 (3.5%) View
EF-hand_like (PF09279) 6364 (2.0%) View
EF-hand_6 (PF13405) 6345 (2.0%) View
Ca_chan_IQ (PF08763) 4709 (1.5%) View
S_100 (PF01023) 4174 (1.3%) View
Cullin_binding (PF03556) 4102 (1.3%) View
Dockerin_1 (PF00404) 4049 (1.3%) View
EF-hand_2 (PF09068) 3996 (1.3%) View
EF-hand_3 (PF09069) 3975 (1.3%) View
EFhand_Ca_insen (PF08726) 3814 (1.2%) View
SPARC_Ca_bdg (PF10591) 3077 (1.0%) View
Pfam family Num. domains Alignment
EF_assoc_2 (PF08356) 2757 (0.9%) View
EF-hand_13 (PF17958) 2036 (0.6%) View
DAG_kinase_N (PF14513) 1935 (0.6%) View
NADPH_Ox (PF08414) 1891 (0.6%) View
Caleosin (PF05042) 1885 (0.6%) View
p25-alpha (PF05517) 1499 (0.5%) View
EF-hand_14 (PF17959) 1426 (0.5%) View
Cbl_N2 (PF02761) 1235 (0.4%) View
EF-hand_11 (PF08976) 585 (0.2%) View
EF-hand_10 (PF14788) 459 (0.1%) View
EF-hand_9 (PF14658) 403 (0.1%) View
WEF-hand (PF19914) 366 (0.1%) View
IQCJ-SCHIP1 (PF15157) 220 (0.1%) View
EF-hand_12 (PF17901) 27 (0.0%) View
Internalin_N (PF12354) 22 (0.0%) View
Total: 31 Total: 315258 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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