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307  structures 8057  species 0  interactions 89127  sequences 1718  architectures

Clan: SGNH_hydrolase (CL0264)

Summary

SGNH hydrolase superfamily Add an annotation

This superfamily contains a diversity of hydrolytic enzyme activities.

This clan contains 16 families and the total number of domains in the clan is 89127. The clan was built by A Bateman.

Literature references

  1. Akoh CC, Lee GC, Liaw YC, Huang TH, Shaw JF; , Prog Lipid Res. 2004;43:534-552.: GDSL family of serine esterases/lipases. PUBMED:15522763 EPMC:15522763
  2. Lo YC, Lin SC, Shaw JF, Liaw YC; , J Mol Biol. 2003;330:539-551.: Crystal structure of Escherichia coli thioesterase I/protease I/lysophospholipase L1: consensus sequence blocks constitute the catalytic center of SGNH-hydrolases through a conserved hydrogen bond network. PUBMED:12842470 EPMC:12842470

Members

This clan contains the following 16 member families:

ALGX DHHW DltD DUF1574 DUF459 DUF4886 GSCFA Hema_esterase Lipase_GDSL Lipase_GDSL_2 Lipase_GDSL_3 Lipase_GDSL_lke OSK PC-Esterase SASA SGNH

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lipase_GDSL_2 (PF13472) 38435 (43.1%) View
Lipase_GDSL (PF00657) 24410 (27.4%) View
PC-Esterase (PF13839) 10956 (12.3%) View
SASA (PF03629) 6189 (6.9%) View
SGNH (PF19040) 3702 (4.2%) View
GSCFA (PF08885) 1242 (1.4%) View
Lipase_GDSL_3 (PF14606) 1219 (1.4%) View
ALGX (PF16822) 1090 (1.2%) View
DHHW (PF14286) 766 (0.9%) View
DltD (PF04914) 403 (0.5%) View
DUF4886 (PF16227) 247 (0.3%) View
DUF459 (PF04311) 238 (0.3%) View
DUF1574 (PF07611) 97 (0.1%) View
OSK (PF17182) 65 (0.1%) View
Lipase_GDSL_lke (PF16255) 46 (0.1%) View
Hema_esterase (PF03996) 22 (0.0%) View
Total: 16 Total: 89127 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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