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1736  structures 7795  species 0  interactions 131940  sequences 4492  architectures

Clan: Transthyretin (CL0287)


Transthyretin superfamily Add an annotation

This clan unifies several SCOP superfamilies that all share a 7 stranded beta sandwich fold.

This clan contains 35 families and the total number of domains in the clan is 131940. The clan was built by A Bateman.


This clan contains the following 35 member families:

CarbopepD_reg_2 CarboxypepD_reg Cna_B CooC_C Dioxygenase_C DUF1416 DUF2012 DUF2606 DUF3823 DUF3869 DUF4139 DUF4198 DUF4458 DUF5300 DUF5979 FctA Fimbrillin_C fn3_3 GramPos_pilinD1 GramPos_pilinD3 Lipase_C MetallophosN PapC_C PEGA phage_tail_N Pollen_Ole_e_1 PUD SdrD_B SpaA SpaA_2 T6_Ig_like T6SS-SciN Transthyretin TTR-52 VHL

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CarbopepD_reg_2 (PF13715) 46068 (34.9%) View
CarboxypepD_reg (PF13620) 22596 (17.1%) View
SpaA (PF17802) 10776 (8.2%) View
Dioxygenase_C (PF00775) 9479 (7.2%) View
SdrD_B (PF17210) 6006 (4.6%) View
Transthyretin (PF00576) 4534 (3.4%) View
Pollen_Ole_e_1 (PF01190) 4142 (3.1%) View
PEGA (PF08308) 3032 (2.3%) View
Cna_B (PF05738) 2952 (2.2%) View
fn3_3 (PF14686) 2620 (2.0%) View
DUF5979 (PF19407) 2503 (1.9%) View
DUF4139 (PF13598) 2396 (1.8%) View
TTR-52 (PF01060) 2174 (1.6%) View
DUF4198 (PF10670) 1985 (1.5%) View
PUD (PF03714) 1559 (1.2%) View
DUF2012 (PF09430) 1549 (1.2%) View
PapC_C (PF13953) 1222 (0.9%) View
FctA (PF12892) 1136 (0.9%) View
Pfam family Num. domains Alignment
T6SS-SciN (PF12790) 970 (0.7%) View
DUF1416 (PF07210) 816 (0.6%) View
MetallophosN (PF16371) 714 (0.5%) View
VHL (PF01847) 713 (0.5%) View
GramPos_pilinD1 (PF16555) 549 (0.4%) View
SpaA_2 (PF19403) 469 (0.4%) View
DUF3823 (PF12866) 308 (0.2%) View
Fimbrillin_C (PF15495) 212 (0.2%) View
Lipase_C (PF18067) 146 (0.1%) View
CooC_C (PF15976) 119 (0.1%) View
phage_tail_N (PF08400) 82 (0.1%) View
DUF4458 (PF14660) 48 (0.0%) View
GramPos_pilinD3 (PF16570) 19 (0.0%) View
DUF3869 (PF12985) 19 (0.0%) View
T6_Ig_like (PF18002) 15 (0.0%) View
DUF2606 (PF10794) 9 (0.0%) View
DUF5300 (PF17224) 3 (0.0%) View
Total: 35 Total: 131940 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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