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831  structures 8696  species 0  interactions 396749  sequences 10140  architectures

Clan: CheY (CL0304)


CheY-like superfamily Add an annotation

This clan includes the CheY-like response regulators from bacteria [1-2].

This clan contains 9 families and the total number of domains in the clan is 396749. The clan was built by A Bateman.

Literature references

  1. Pao GM, Saier MH; , J Mol Evol 1995;40:136-154.: Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution. PUBMED:7699720 EPMC:7699720
  2. Galperin MY; , J Bacteriol. 2006;188:4169-4182.: Structural classification of bacterial response regulators: diversity of output domains and domain combinations. PUBMED:16740923 EPMC:16740923


This clan contains the following 9 member families:

FleQ OKR_DC_1_N RcsC RcsD_ABL Response_reg Response_reg_2 TadZ_N UPF0004 VpsR

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Response_reg (PF00072) 375727 (94.7%) View
UPF0004 (PF00919) 18391 (4.6%) View
OKR_DC_1_N (PF03709) 1330 (0.3%) View
FleQ (PF06490) 481 (0.1%) View
VpsR (PF20161) 451 (0.1%) View
RcsC (PF09456) 111 (0.0%) View
RcsD_ABL (PF16359) 105 (0.0%) View
TadZ_N (PF16968) 85 (0.0%) View
Response_reg_2 (PF19192) 68 (0.0%) View
Total: 9 Total: 396749 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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