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96  structures 8368  species 0  interactions 21236  sequences 293  architectures

Clan: RNase_III (CL0539)


RNase III domain-like superfamily Add an annotation

This superfamily is characterised structurally by having a core of 5 helices where one of the helices is surrounded by the others. Many members have the endonuclease catalytic domain.

This clan contains 3 families and the total number of domains in the clan is 21236. The clan was built by P Coggill.


This clan contains the following 3 member families:

Ribonucleas_3_2 Ribonucleas_3_3 Ribonuclease_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ribonuclease_3 (PF00636) 11434 (53.8%) View
Ribonucleas_3_3 (PF14622) 9788 (46.1%) View
Ribonucleas_3_2 (PF11469) 14 (0.1%) View
Total: 3 Total: 21236 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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