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236  structures 3163  species 8  interactions 10523  sequences 437  architectures

Clan: Hexosaminidase (CL0546)


beta-N-acetylhexosaminidase-like domain Add an annotation

This superfamily is characterised by a mixed beta sheet with connection over the free side of the sheet. The fold is like a zincin fold lacking the catalytic centre.

This clan contains 5 families and the total number of domains in the clan is 10523. The clan was built by P Coggill.

Literature references

  1. Golan G, Shallom D, Teplitsky A, Zaide G, Shulami S, Baasov T, Stojanoff V, Thompson A, Shoham Y, Shoham G;, J Biol Chem. 2004;279:3014-3024.: Crystal structures of Geobacillus stearothermophilus alpha-glucuronidase complexed with its substrate and products: mechanistic implications. PUBMED:14573597 EPMC:14573597


This clan contains the following 5 member families:

GcnA_N Glyco_hydro_20b Glyco_hydro_67N Glycohydro_20b2 NAGLU_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glyco_hydro_20b (PF02838) 5816 (55.3%) View
Glycohydro_20b2 (PF14845) 2447 (23.3%) View
NAGLU_N (PF12971) 1283 (12.2%) View
Glyco_hydro_67N (PF03648) 960 (9.1%) View
GcnA_N (PF18229) 17 (0.2%) View
Total: 5 Total: 10523 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 8 interactions for this clan. More...

Interacting families
Glyco_hydro_20 Glycohydro_20b2
Glyco_hydro_20b Glyco_hydro_20
Glyco_hydro_67N Glyco_hydro_67C
Glycohydro_20b2 Glyco_hydro_20


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...