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3431  structures 8951  species 0  interactions 463127  sequences 5155  architectures

Clan: Cupin (CL0029)


Cupin fold Add an annotation

This clan represents the conserved barrel domain of the 'cupin' superfamily [1] ('cupa' is the Latin term for a small barrel). The cupin fold is found in a wide variety of enzymes, but notably contains the non-enzymatic seed storage proteins also.

This clan contains 66 families and the total number of domains in the clan is 463127. The clan was built by A Bateman.

Literature references

  1. Dunwell JM; , Biotechnol Genet Eng Rev 1998;15:1-32.: Cupins: a new superfamily of functionally diverse proteins that include germins and plant storage proteins. PUBMED:9573603 EPMC:9573603


This clan contains the following 66 member families:

2OG-Fe_Oxy_2 2OG-FeII_Oxy 2OG-FeII_Oxy_2 2OG-FeII_Oxy_3 2OG-FeII_Oxy_4 2OG-FeII_Oxy_5 3-HAO AIM24 AraC_binding AraC_binding_2 AraC_N ARD Asp_Arg_Hydrox AUDH_Cupin Auxin_BP CDO_I CENP-C_C cNMP_binding CsiD Cupin_1 Cupin_2 Cupin_3 Cupin_4 Cupin_5 Cupin_6 Cupin_7 Cupin_8 DIOX_N DMSP_lyase dTDP_sugar_isom DUF1479 DUF1971 DUF386 DUF4437 DUF4867 DUF5070 DUF6016 Ectoine_synth ERG2_Sigma1R EutQ FdtA FTO_NTD GPI HgmA HutD JmjC JmjN KduI Lyx_isomer MannoseP_isomer Ofd1_CTDD Oxygenase-NA PCO_ADO PhyH Pirin Pirin_C Pirin_C_2 PMI_typeI Popeye Pox_C4_C10 Ppnp TauD Tet_JBP Ureidogly_lyase VIT VIT_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
cNMP_binding (PF00027) 78333 (16.9%) View
Cupin_2 (PF07883) 48831 (10.5%) View
2OG-FeII_Oxy (PF03171) 35075 (7.6%) View
DIOX_N (PF14226) 32070 (6.9%) View
AraC_binding (PF02311) 21890 (4.7%) View
TauD (PF02668) 17976 (3.9%) View
JmjC (PF02373) 16909 (3.7%) View
2OG-FeII_Oxy_3 (PF13640) 16815 (3.6%) View
PhyH (PF05721) 16381 (3.5%) View
Cupin_1 (PF00190) 16200 (3.5%) View
Pirin (PF02678) 13497 (2.9%) View
2OG-FeII_Oxy_2 (PF13532) 12207 (2.6%) View
Cupin_8 (PF13621) 9977 (2.2%) View
Pirin_C (PF05726) 8903 (1.9%) View
dTDP_sugar_isom (PF00908) 7598 (1.6%) View
JmjN (PF02375) 7380 (1.6%) View
AIM24 (PF01987) 7268 (1.6%) View
PMI_typeI (PF01238) 7056 (1.5%) View
HgmA (PF04209) 5181 (1.1%) View
VIT (PF08487) 4997 (1.1%) View
MannoseP_isomer (PF01050) 4836 (1.0%) View
AraC_binding_2 (PF14525) 4450 (1.0%) View
Cupin_6 (PF12852) 4114 (0.9%) View
KduI (PF04962) 3984 (0.9%) View
Cupin_3 (PF05899) 3902 (0.8%) View
Pirin_C_2 (PF17954) 3705 (0.8%) View
Cupin_4 (PF08007) 3612 (0.8%) View
Cupin_7 (PF12973) 3519 (0.8%) View
CDO_I (PF05995) 3353 (0.7%) View
Cupin_5 (PF06172) 3152 (0.7%) View
AraC_N (PF06719) 3105 (0.7%) View
Asp_Arg_Hydrox (PF05118) 3015 (0.7%) View
ARD (PF03079) 2948 (0.6%) View
Ureidogly_lyase (PF04115) 2219 (0.5%) View
Pfam family Num. domains Alignment
PCO_ADO (PF07847) 2101 (0.5%) View
3-HAO (PF06052) 2027 (0.4%) View
2OG-FeII_Oxy_4 (PF13661) 1570 (0.3%) View
DUF1479 (PF07350) 1534 (0.3%) View
Ectoine_synth (PF06339) 1516 (0.3%) View
DUF386 (PF04074) 1507 (0.3%) View
HutD (PF05962) 1388 (0.3%) View
2OG-FeII_Oxy_5 (PF13759) 1362 (0.3%) View
Ofd1_CTDD (PF10637) 1353 (0.3%) View
FdtA (PF05523) 1330 (0.3%) View
Ppnp (PF06865) 1292 (0.3%) View
ERG2_Sigma1R (PF04622) 1291 (0.3%) View
Tet_JBP (PF12851) 1147 (0.2%) View
Popeye (PF04831) 1102 (0.2%) View
CENP-C_C (PF11699) 1018 (0.2%) View
2OG-Fe_Oxy_2 (PF10014) 1007 (0.2%) View
EutQ (PF06249) 912 (0.2%) View
Oxygenase-NA (PF09859) 888 (0.2%) View
Lyx_isomer (PF07385) 627 (0.1%) View
FTO_NTD (PF12933) 593 (0.1%) View
DUF1971 (PF09313) 501 (0.1%) View
VIT_2 (PF13757) 428 (0.1%) View
GPI (PF06560) 398 (0.1%) View
DMSP_lyase (PF16867) 324 (0.1%) View
DUF4867 (PF16161) 309 (0.1%) View
DUF4437 (PF14499) 295 (0.1%) View
Auxin_BP (PF02041) 290 (0.1%) View
DUF6016 (PF19480) 275 (0.1%) View
CsiD (PF08943) 149 (0.0%) View
AUDH_Cupin (PF18637) 92 (0.0%) View
Pox_C4_C10 (PF03336) 40 (0.0%) View
DUF5070 (PF16802) 3 (0.0%) View
Total: 66 Total: 463127
No alignment ℹ

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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