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3307  structures 9137  species 0  interactions 477355  sequences 5156  architectures

Clan: Cupin (CL0029)

Summary

Cupin fold Add an annotation

This clan represents the conserved barrel domain of the 'cupin' superfamily [1] ('cupa' is the Latin term for a small barrel). The cupin fold is found in a wide variety of enzymes, but notably contains the non-enzymatic seed storage proteins also.

This clan contains 69 families and the total number of domains in the clan is 477355. The clan was built by A Bateman.

Literature references

  1. Dunwell JM; , Biotechnol Genet Eng Rev 1998;15:1-32.: Cupins: a new superfamily of functionally diverse proteins that include germins and plant storage proteins. PUBMED:9573603 EPMC:9573603

Members

This clan contains the following 69 member families:

2OG-Fe_Oxy_2 2OG-FeII_Oxy 2OG-FeII_Oxy_2 2OG-FeII_Oxy_3 2OG-FeII_Oxy_4 2OG-FeII_Oxy_5 2OG-FeII_Oxy_6 3-HAO AIM24 AraC_binding AraC_binding_2 AraC_N ARD Asp_Arg_Hydrox AUDH_Cupin Auxin_BP CDO_I CENP-C_C cNMP_binding CsiD Cupin_1 Cupin_2 Cupin_3 Cupin_5 Cupin_6 Cupin_7 Cupin_8 DIOX_N DMSP_lyase dTDP_sugar_isom DUF1479 DUF1971 DUF386 DUF4437 DUF4867 DUF5070 DUF6016 Ectoine_synth ERG2_Sigma1R EutQ FdtA FTO_NTD GPI HgmA_C HgmA_N HutD JmjC JmjC_2 JmjN KduI Lyx_isomer MannoseP_isomer Ofd1_CTDD Oxygenase-NA PCO_ADO PhyH Pirin Pirin_C Pirin_C_2 PMI_typeI_C PMI_typeI_cat Popeye Pox_C4_C10 Ppnp TauD Tet_JBP Ureidogly_lyase VIT VIT_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
cNMP_binding (PF00027) 87173 (18.3%) View
2OG-FeII_Oxy (PF03171) 37065 (7.8%) View
AraC_binding (PF02311) 37024 (7.8%) View
DIOX_N (PF14226) 34382 (7.2%) View
Cupin_1 (PF00190) 22409 (4.7%) View
JmjC (PF02373) 20428 (4.3%) View
2OG-FeII_Oxy_3 (PF13640) 18586 (3.9%) View
TauD (PF02668) 18506 (3.9%) View
PhyH (PF05721) 17077 (3.6%) View
Pirin (PF02678) 14141 (3.0%) View
2OG-FeII_Oxy_2 (PF13532) 13132 (2.8%) View
Cupin_8 (PF13621) 10916 (2.3%) View
Pirin_C (PF05726) 9281 (1.9%) View
JmjN (PF02375) 8894 (1.9%) View
dTDP_sugar_isom (PF00908) 7886 (1.7%) View
AIM24 (PF01987) 7524 (1.6%) View
Cupin_3 (PF05899) 6668 (1.4%) View
PMI_typeI_cat (PF20511) 6581 (1.4%) View
VIT (PF08487) 6310 (1.3%) View
MannoseP_isomer (PF01050) 5726 (1.2%) View
HgmA_N (PF20510) 5269 (1.1%) View
AraC_binding_2 (PF14525) 4733 (1.0%) View
HgmA_C (PF04209) 4457 (0.9%) View
Cupin_6 (PF12852) 4308 (0.9%) View
KduI (PF04962) 4117 (0.9%) View
JmjC_2 (PF08007) 3912 (0.8%) View
Cupin_7 (PF12973) 3873 (0.8%) View
Pirin_C_2 (PF17954) 3866 (0.8%) View
CDO_I (PF05995) 3512 (0.7%) View
Asp_Arg_Hydrox (PF05118) 3464 (0.7%) View
Cupin_5 (PF06172) 3293 (0.7%) View
AraC_N (PF06719) 3222 (0.7%) View
ARD (PF03079) 3147 (0.7%) View
PCO_ADO (PF07847) 2280 (0.5%) View
Ureidogly_lyase (PF04115) 2266 (0.5%) View
continued
Pfam family Num. domains Alignment
3-HAO (PF06052) 2193 (0.5%) View
2OG-FeII_Oxy_4 (PF13661) 1697 (0.4%) View
PMI_typeI_C (PF01238) 1672 (0.4%) View
Ectoine_synth (PF06339) 1588 (0.3%) View
DUF386 (PF04074) 1574 (0.3%) View
DUF1479 (PF07350) 1552 (0.3%) View
Ofd1_CTDD (PF10637) 1469 (0.3%) View
HutD (PF05962) 1451 (0.3%) View
Tet_JBP (PF12851) 1407 (0.3%) View
2OG-FeII_Oxy_5 (PF13759) 1391 (0.3%) View
Popeye (PF04831) 1389 (0.3%) View
FdtA (PF05523) 1375 (0.3%) View
ERG2_Sigma1R (PF04622) 1368 (0.3%) View
Ppnp (PF06865) 1346 (0.3%) View
EutQ (PF06249) 1241 (0.3%) View
CENP-C_C (PF11699) 1189 (0.2%) View
2OG-Fe_Oxy_2 (PF10014) 1049 (0.2%) View
2OG-FeII_Oxy_6 (PF20515) 1031 (0.2%) View
Oxygenase-NA (PF09859) 916 (0.2%) View
FTO_NTD (PF12933) 736 (0.2%) View
Lyx_isomer (PF07385) 653 (0.1%) View
VIT_2 (PF13757) 576 (0.1%) View
DUF1971 (PF09313) 523 (0.1%) View
Auxin_BP (PF02041) 449 (0.1%) View
GPI (PF06560) 409 (0.1%) View
DMSP_lyase (PF16867) 399 (0.1%) View
DUF4437 (PF14499) 385 (0.1%) View
DUF4867 (PF16161) 313 (0.1%) View
DUF6016 (PF19480) 292 (0.1%) View
CsiD (PF08943) 154 (0.0%) View
AUDH_Cupin (PF18637) 93 (0.0%) View
Pox_C4_C10 (PF03336) 45 (0.0%) View
DUF5070 (PF16802) 2 (0.0%) View
Cupin_2 (PF07883) 0 (0.0%) View
Total: 69 Total: 477355
No alignment ℹ
 

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Family relationships

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Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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