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214  structures 5855  species 8  interactions 13042  sequences 85  architectures

Clan: GME (CL0197)


GME superfamily Add an annotation

This superfamily contains a number of related enzymes such as AstB, peptidyl-arginine deiminase, arginine deiminase and amidinotransferase [1,2].

This clan contains 5 families and the total number of domains in the clan is 13042. The clan was built by A Bateman and H Shirai.

Literature references

  1. Shirai H, Blundell TL, Mizuguchi K; , Trends Biochem Sci 2001;26:465-468.: A novel superfamily of enzymes that catalyze the modification of guanidino groups. PUBMED:11504612 EPMC:11504612
  2. Shirai H, Mizuguchi K; , FEBS Lett 2003;555:505-510.: Prediction of the structure and function of AstA and AstB, the first two enzymes of the arginine succinyltransferase pathway of arginine catabolism. PUBMED:14675764 EPMC:14675764


This clan contains the following 5 member families:

Amidinotransf AstB eIF-6 PAD PAD_porph

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Amidinotransf (PF02274) 5886 (45.1%) View
PAD_porph (PF04371) 3552 (27.2%) View
eIF-6 (PF01912) 1761 (13.5%) View
PAD (PF03068) 1025 (7.9%) View
AstB (PF04996) 818 (6.3%) View
Total: 5 Total: 13042 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 8 interactions for this clan. More...

Interacting families
Amidinotransf Amidinotransf
AstB AstB
eIF-6 eIF-6
PAD_porph PAD_porph


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...