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1530  structures 8231  species 30  interactions 303659  sequences 3722  architectures

Clan: GT-A (CL0110)


Glycosyl transferase clan GT-A Add an annotation

This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].

This clan contains 52 families and the total number of domains in the clan is 303659. The clan was built by A Bateman.

Literature references

  1. Liu J, Mushegian A; , Protein Sci 2003;12:1418-1431.: Three monophyletic superfamilies account for the majority of the known glycosyltransferases. PUBMED:12824488 EPMC:12824488


This clan contains the following 52 member families:

Anp1 Branch Caps_synth Cellulose_synt CgtA CHGN Chitin_synth_1 Chitin_synth_2 CofC CTP_transf_3 DUF2064 DUF273 DUF604 Fringe Galactosyl_T GlcNAc Gly_transf_sug Glyco_tranf_2_2 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5 Glyco_trans_2_3 Glyco_transf_15 Glyco_transf_21 Glyco_transf_24 Glyco_transf_25 Glyco_transf_34 Glyco_transf_43 Glyco_transf_49 Glyco_transf_6 Glyco_transf_64 Glyco_transf_7C Glyco_transf_7N Glyco_transf_8 Glyco_transf_88 Glyco_transf_92 Glycos_transf_2 GNT-I IspD Mannosyl_trans3 MGAT2 NTP_transf_3 NTP_transferase Nucleotid_trans Osmo_MPGsynth Pox_P35 RGP Rhamno_transf STELLO TcdA_TcdB UDP-g_GGTase UDPGP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glycos_transf_2 (PF00535) 96418 (31.8%) View
NTP_transferase (PF00483) 39433 (13.0%) View
NTP_transf_3 (PF12804) 17098 (5.6%) View
Glyco_tranf_2_3 (PF13641) 12646 (4.2%) View
Glyco_transf_8 (PF01501) 11951 (3.9%) View
Galactosyl_T (PF01762) 9358 (3.1%) View
Branch (PF02485) 8141 (2.7%) View
Cellulose_synt (PF03552) 7570 (2.5%) View
CTP_transf_3 (PF02348) 7329 (2.4%) View
IspD (PF01128) 7171 (2.4%) View
Gly_transf_sug (PF04488) 6122 (2.0%) View
Glyco_trans_2_3 (PF13632) 5686 (1.9%) View
UDPGP (PF01704) 5181 (1.7%) View
Chitin_synth_2 (PF03142) 4468 (1.5%) View
Fringe (PF02434) 4066 (1.3%) View
Glyco_transf_7C (PF02709) 4015 (1.3%) View
Glyco_transf_92 (PF01697) 3410 (1.1%) View
Nucleotid_trans (PF03407) 3396 (1.1%) View
Mannosyl_trans3 (PF11051) 3322 (1.1%) View
Glyco_tranf_2_4 (PF13704) 3127 (1.0%) View
Glyco_transf_15 (PF01793) 3089 (1.0%) View
Glyco_transf_34 (PF05637) 2785 (0.9%) View
Glyco_transf_49 (PF13896) 2774 (0.9%) View
Glyco_transf_64 (PF09258) 2744 (0.9%) View
Glyco_transf_7N (PF13733) 2672 (0.9%) View
Glyco_transf_25 (PF01755) 2621 (0.9%) View
Chitin_synth_1 (PF01644) 2477 (0.8%) View
Pfam family Num. domains Alignment
Glyco_transf_21 (PF13506) 2351 (0.8%) View
Glyco_transf_43 (PF03360) 2285 (0.8%) View
CHGN (PF05679) 2219 (0.7%) View
DUF604 (PF04646) 2016 (0.7%) View
DUF2064 (PF09837) 1924 (0.6%) View
Anp1 (PF03452) 1713 (0.6%) View
Glyco_transf_24 (PF18404) 1701 (0.6%) View
UDP-g_GGTase (PF06427) 1559 (0.5%) View
GNT-I (PF03071) 1423 (0.5%) View
Glyco_transf_6 (PF03414) 1073 (0.4%) View
CofC (PF01983) 939 (0.3%) View
RGP (PF03214) 881 (0.3%) View
Caps_synth (PF05704) 804 (0.3%) View
MGAT2 (PF05060) 757 (0.2%) View
GlcNAc (PF11397) 603 (0.2%) View
STELLO (PF03385) 533 (0.2%) View
DUF273 (PF03314) 527 (0.2%) View
Rhamno_transf (PF11316) 483 (0.2%) View
Glyco_tranf_2_5 (PF13712) 333 (0.1%) View
Glyco_tranf_2_2 (PF10111) 230 (0.1%) View
Osmo_MPGsynth (PF09488) 88 (0.0%) View
TcdA_TcdB (PF12919) 56 (0.0%) View
CgtA (PF06306) 33 (0.0%) View
Pox_P35 (PF03213) 32 (0.0%) View
Glyco_transf_88 (PF16849) 26 (0.0%) View
Total: 52 Total: 303659
No alignment ℹ

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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