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63  structures 1491  species 0  interactions 26720  sequences 830  architectures

Clan: Hect (CL0552)


Hect, E3 ligase catalytic domain Add an annotation

This superfamily is characterised by fmailies with E3-ligase catalytic acitvity. The fold consists of two alpha+beta domains; where the N-terminal domain is an array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit.

This clan contains 2 families and the total number of domains in the clan is 26720. The clan was built by P Coggill.

Literature references

  1. Kobirumaki F, Miyauchi Y, Fukami K, Tanaka H;, J Biochem. 2005;137:133-139.: A novel UbcH10-binding protein facilitates the ubiquitinylation of cyclin B in vitro. PUBMED:15749827 EPMC:15749827


This clan contains the following 2 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HECT (PF00632) 25162 (94.2%) View
HECT_2 (PF09814) 1558 (5.8%) View
Total: 2 Total: 26720 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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