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10580  structures 9259  species 0  interactions 1049254  sequences 22155  architectures

Clan: PKinase (CL0016)


Protein kinase superfamily Add an annotation

This superfamily includes the Serine/Threonine- and Tyrosine- protein kinases as well as related kinases that act on non-protein substrates.

This clan contains 40 families and the total number of domains in the clan is 1049254. The clan was built by DJ Studholme.

Literature references

  1. Hanks SK, Quinn AM; , Methods Enzymol 1991;200:38-62.: Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. PUBMED:1956325 EPMC:1956325
  2. Hanks SK, Hunter T; , FASEB J 1995;9:576-596.: Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. PUBMED:7768349 EPMC:7768349
  3. Hunter T, Plowman GD; , Trends Biochem Sci 1997;22:18-22.: The protein kinases of budding yeast: six score and more. PUBMED:9020587 EPMC:9020587


This clan contains the following 40 member families:

ABC1 AceK_kinase Act-Frag_cataly Alpha_kinase APH APH_6_hur Choline_kinase CotH DUF1679 DUF2252 DUF4135 DUF5898 EcKL Fam20C Fructosamin_kin FTA2 Haspin_kinase HipA_C Ins_P5_2-kin IPK IucA_IucC Kdo Kinase-like Kinase-PolyVal KIND Pan3_PK PI3_PI4_kinase PIP49_C PIP5K PK_Tyr_Ser-Thr Pkinase Pkinase_fungal Pox_ser-thr_kin RIO1 Seadorna_VP7 TCAD9 UL97 WaaY YrbL-PhoP_reg YukC

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Pkinase (PF00069) 636438 (60.7%) View
PK_Tyr_Ser-Thr (PF07714) 212672 (20.3%) View
APH (PF01636) 52239 (5.0%) View
PI3_PI4_kinase (PF00454) 27225 (2.6%) View
ABC1 (PF03109) 22853 (2.2%) View
PIP5K (PF01504) 16009 (1.5%) View
Pkinase_fungal (PF17667) 10576 (1.0%) View
RIO1 (PF01163) 6939 (0.7%) View
Choline_kinase (PF01633) 6654 (0.6%) View
IPK (PF03770) 5899 (0.6%) View
Fructosamin_kin (PF03881) 5078 (0.5%) View
EcKL (PF02958) 5034 (0.5%) View
HipA_C (PF07804) 4971 (0.5%) View
Alpha_kinase (PF02816) 4471 (0.4%) View
Kdo (PF06293) 4428 (0.4%) View
CotH (PF08757) 3477 (0.3%) View
IucA_IucC (PF04183) 3384 (0.3%) View
DUF2252 (PF10009) 2616 (0.2%) View
PIP49_C (PF12260) 2504 (0.2%) View
Ins_P5_2-kin (PF06090) 2115 (0.2%) View
Fam20C (PF06702) 2011 (0.2%) View
Pfam family Num. domains Alignment
APH_6_hur (PF04655) 1933 (0.2%) View
KIND (PF16474) 1896 (0.2%) View
Pan3_PK (PF18101) 1834 (0.2%) View
Haspin_kinase (PF12330) 1547 (0.1%) View
DUF1679 (PF07914) 943 (0.1%) View
AceK_kinase (PF06315) 816 (0.1%) View
DUF4135 (PF13575) 745 (0.1%) View
Act-Frag_cataly (PF09192) 472 (0.0%) View
FTA2 (PF13095) 385 (0.0%) View
YrbL-PhoP_reg (PF10707) 294 (0.0%) View
YukC (PF10140) 205 (0.0%) View
Kinase-like (PF14531) 139 (0.0%) View
WaaY (PF06176) 128 (0.0%) View
Kinase-PolyVal (PF18762) 108 (0.0%) View
TCAD9 (PF19974) 83 (0.0%) View
Pox_ser-thr_kin (PF05445) 48 (0.0%) View
DUF5898 (PF19250) 45 (0.0%) View
UL97 (PF06734) 29 (0.0%) View
Seadorna_VP7 (PF07387) 11 (0.0%) View
Total: 40 Total: 1049254
No alignment ℹ

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...