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159  structures 1107  species 8  interactions 9778  sequences 234  architectures

Clan: Triple_barrel (CL0662)

Summary

Triple barrel superfamily Add an annotation

Members of this superfamily adopt a triple barrel fold. This fold was first identified in the structure of the homodimer of RAP30 and RAP74. The two proteins form a single core structure composed of three interwoven beta barrels [1]. The central barrel is composed of beta strands from both heterodimer subunits. A similar fold has been observed in the heterodimer of TAF1 and TAF7 [2].

This clan contains 9 families and the total number of domains in the clan is 9778. The clan was built by A Bateman.

Literature references

  1. Gaiser F, Tan S, Richmond TJ;, J Mol Biol. 2000;302:1119-1127.: Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution. PUBMED:11183778 EPMC:11183778
  2. Wang H, Curran EC, Hinds TR, Wang EH, Zheng N;, Cell Res. 2014;24:1433-1444.: Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. PUBMED:25412659 EPMC:25412659

Members

This clan contains the following 9 member families:

DUF3591 RNA_pol_I_A49 RNA_pol_Rpc4 RNA_polI_A34 RNase_H2_suC Sin_N TAFII55_N TFIIF_beta_N Ydr279_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DUF3591 (PF12157) 1444 (14.8%) View
Sin_N (PF04801) 1309 (13.4%) View
TAFII55_N (PF04658) 1277 (13.1%) View
RNA_pol_Rpc4 (PF05132) 1212 (12.4%) View
RNA_pol_I_A49 (PF06870) 1140 (11.7%) View
TFIIF_beta_N (PF17683) 1016 (10.4%) View
RNase_H2_suC (PF08615) 918 (9.4%) View
Ydr279_N (PF17745) 829 (8.5%) View
RNA_polI_A34 (PF08208) 633 (6.5%) View
Total: 9 Total: 9778 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 8 interactions for this clan. More...

Interacting families
A B
RNA_pol_I_A49 RNA_pol_I_A49
RNA_polI_A34
RNA_polI_A34 RNA_pol_I_A49
RNA_polI_A34
RNase_H2-Ydr279 RNase_H2_suC
RNase_H2_suC RNase_H2_suC
RNase_HII
RNase_HII RNase_H2_suC

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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