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964  structures 8093  species 0  interactions 98862  sequences 856  architectures

Family: Abhydrolase_1 (PF00561)

Summary: alpha/beta hydrolase fold

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Alpha/beta hydrolase fold". More...

Alpha/beta hydrolase fold Edit Wikipedia article

  • From a page move: This is a redirect from a page that has been moved (renamed). This page was kept as a redirect to avoid breaking links, both internal and external, that may have been made to the old page name.

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

alpha/beta hydrolase fold Provide feedback

This catalytic domain is found in a very wide range of enzymes.

Literature references

  1. Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag J, Sussman JL, Verschueren KHG, Goldman A; , Protein Eng 1992;5:197-211.: The alpha/beta hydrolase fold PUBMED:1409539 EPMC:1409539


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000073

The alpha/beta hydrolase fold [ PUBMED:1409539 ] is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 strands connected by helices [ PUBMED:1409539 ]. The enzymes are believed to have diverged from a common ancestor, preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best conserved structural features of the fold. Esterase (EST) from Pseudomonas putida is a member of the alpha/beta hydrolase fold superfamily of enzymes [ PUBMED:16321951 ].

In most of the family members the beta-strands are parallels, but some have an inversion of the first strands, which gives it an antiparallel orientation. The catalytic triad residues are presented on loops. One of these is the nucleophile elbow and is the most conserved feature of the fold. Some other members lack one or all of the catalytic residues. Some members are therefore inactive but others are involved in surface recognition. The ESTHER database [ PUBMED:14681380 ] gathers and annotates all the published information related to gene and protein sequences of this superfamily [ PUBMED:14681380 ].

This entry represents fold-1 of alpha/beta hydrolase.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(48)
Full
(98862)
Representative proteomes UniProt
(366335)
RP15
(10914)
RP35
(41479)
RP55
(92720)
RP75
(161091)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(48)
Full
(98862)
Representative proteomes UniProt
(366335)
RP15
(10914)
RP35
(41479)
RP55
(92720)
RP75
(161091)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(48)
Full
(98862)
Representative proteomes UniProt
(366335)
RP15
(10914)
RP35
(41479)
RP55
(92720)
RP75
(161091)
Raw Stockholm Download   Download   Download   Download   Download      
Gzipped Download   Download   Download   Download   Download      

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: MRC-LMB Genome group
Previous IDs: abhydrolase;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 48
Number in full: 98862
Average length of the domain: 213.70 aa
Average identity of full alignment: 15 %
Average coverage of the sequence by the domain: 59.61 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.8 25.8
Trusted cut-off 25.8 25.8
Noise cut-off 25.7 25.7
Model length: 257
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Abhydrolase_1 domain has been found. There are 964 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K337 View 3D Structure Click here
A0A0G2K430 View 3D Structure Click here
A0A0N7KCX9 View 3D Structure Click here
A0A0P0WIT7 View 3D Structure Click here
A0A0P0WSK2 View 3D Structure Click here
A0A0P0XW79 View 3D Structure Click here
A0A0P0XWE4 View 3D Structure Click here
A0A0R0EQP0 View 3D Structure Click here
A0A0R0ESZ9 View 3D Structure Click here
A0A0R0EUK2 View 3D Structure Click here
A0A0R0EWP2 View 3D Structure Click here
A0A0R0F394 View 3D Structure Click here
A0A0R0F3F2 View 3D Structure Click here
A0A0R0H2F6 View 3D Structure Click here
A0A0R0IFF4 View 3D Structure Click here
A0A0R0JG33 View 3D Structure Click here
A0A0R0JU43 View 3D Structure Click here
A0A0R0JUR8 View 3D Structure Click here
A0A0R0K0D2 View 3D Structure Click here
A0A0R0K3T3 View 3D Structure Click here
A0A0R0KMG2 View 3D Structure Click here
A0A0R0KMM0 View 3D Structure Click here
A0A0R0KP45 View 3D Structure Click here
A0A0R4ICG7 View 3D Structure Click here
A0A0R4IDE5 View 3D Structure Click here
A0A0R4IK35 View 3D Structure Click here
A0A0R4ILH2 View 3D Structure Click here
A0A0R4ILM1 View 3D Structure Click here
A0A0R4IN27 View 3D Structure Click here
A0A1D6FJB0 View 3D Structure Click here
A0A1D6GDU2 View 3D Structure Click here
A0A1D6I3S0 View 3D Structure Click here
A0A1D6IJ12 View 3D Structure Click here
A0A1D6IK15 View 3D Structure Click here
A0A1D6INV2 View 3D Structure Click here
A0A1D6J508 View 3D Structure Click here
A0A1D6K7D3 View 3D Structure Click here
A0A1D6KCC9 View 3D Structure Click here
A0A1D6LKG7 View 3D Structure Click here
A0A1D6LR25 View 3D Structure Click here
A0A1D6M5I9 View 3D Structure Click here
A0A1D6MBG6 View 3D Structure Click here
A0A1D6MPS7 View 3D Structure Click here
A0A1D6MV47 View 3D Structure Click here
A0A1D6N330 View 3D Structure Click here
A0A1D6NLB6 View 3D Structure Click here
A0A1D6PMQ8 View 3D Structure Click here
A0A1D6Q677 View 3D Structure Click here
A0A1D6QMY4 View 3D Structure Click here
A0A1D8PD05 View 3D Structure Click here
A0A1D8PDD7 View 3D Structure Click here
A0A1D8PFA3 View 3D Structure Click here
A0A1D8PHY7 View 3D Structure Click here
A0A1D8PIA5 View 3D Structure Click here
A0A1D8PJM5 View 3D Structure Click here
A0A1D8PPA2 View 3D Structure Click here
A0A1D8PPD3 View 3D Structure Click here
A0A1D8PRJ0 View 3D Structure Click here
A0A1P8BDU6 View 3D Structure Click here
A0A2R8QBC9 View 3D Structure Click here
A0A2R8QM09 View 3D Structure Click here
A1Z7Q7 View 3D Structure Click here
A2BGU9 View 3D Structure Click here
A4HXH8 View 3D Structure Click here
A4HXI1 View 3D Structure Click here
A4HXI2 View 3D Structure Click here
A4HXI3 View 3D Structure Click here
A4I3N6 View 3D Structure Click here
A4I8Q4 View 3D Structure Click here
B4F869 View 3D Structure Click here
B4FAQ7 View 3D Structure Click here
B4FNN8 View 3D Structure Click here
B4FP91 View 3D Structure Click here
B4FQ76 View 3D Structure Click here
B5DEN3 View 3D Structure Click here
B5X0N4 View 3D Structure Click here
B6SUW2 View 3D Structure Click here
B6TJ32 View 3D Structure Click here
B6U4K5 View 3D Structure Click here
C0PGW3 View 3D Structure Click here
C6S3G2 View 3D Structure Click here
C6T8Y6 View 3D Structure Click here
C6TEM2 View 3D Structure Click here
C6TIE2 View 3D Structure Click here
C6TNC5 View 3D Structure Click here
D3ZAW4 View 3D Structure Click here
D3ZKP8 View 3D Structure Click here
D4A071 View 3D Structure Click here
D4A3D4 View 3D Structure Click here
D4A9L7 View 3D Structure Click here
D4AA61 View 3D Structure Click here
D5SHT6 View 3D Structure Click here
E2QCS7 View 3D Structure Click here
E7F070 View 3D Structure Click here
F1Q6S4 View 3D Structure Click here
F1R264 View 3D Structure Click here
F1REU1 View 3D Structure Click here
F4JKY6 View 3D Structure Click here
F4JSJ6 View 3D Structure Click here
F6WYC8 View 3D Structure Click here
F8W4T1 View 3D Structure Click here
G5EBI4 View 3D Structure Click here
G5EDL5 View 3D Structure Click here
H2KZ86 View 3D Structure Click here
I1JCL2 View 3D Structure Click here
I1JCP7 View 3D Structure Click here
I1JCW2 View 3D Structure Click here
I1JCW3 View 3D Structure Click here
I1JME3 View 3D Structure Click here
I1JQ12 View 3D Structure Click here
I1JR88 View 3D Structure Click here
I1JT54 View 3D Structure Click here
I1JU24 View 3D Structure Click here
I1K0H3 View 3D Structure Click here
I1K8H7 View 3D Structure Click here
I1KMX1 View 3D Structure Click here
I1KUC7 View 3D Structure Click here
I1LBX8 View 3D Structure Click here
I1LES8 View 3D Structure Click here
I1LP28 View 3D Structure Click here
I1M0D1 View 3D Structure Click here
I1M0D3 View 3D Structure Click here
I1M3U3 View 3D Structure Click here
I1MAK4 View 3D Structure Click here
I1ME45 View 3D Structure Click here
I1MVQ2 View 3D Structure Click here
I1MY10 View 3D Structure Click here
I1N7A3 View 3D Structure Click here
I1NB78 View 3D Structure Click here
I1NBV8 View 3D Structure Click here
I1NBZ1 View 3D Structure Click here
I1NJ31 View 3D Structure Click here
I6Y8X0 View 3D Structure Click here
I6YC03 View 3D Structure Click here
I6YGS0 View 3D Structure Click here
K7K4J0 View 3D Structure Click here
K7KBZ6 View 3D Structure Click here
K7LG12 View 3D Structure Click here
K7LHI7 View 3D Structure Click here
K7LU64 View 3D Structure Click here
K7MJN4 View 3D Structure Click here
K7MLH4 View 3D Structure Click here
K7MUD9 View 3D Structure Click here
K7MWZ7 View 3D Structure Click here
K7N313 View 3D Structure Click here
K7TN03 View 3D Structure Click here
K7UBA1 View 3D Structure Click here
K7V7D6 View 3D Structure Click here
K7VEB4 View 3D Structure Click here
M9PCU5 View 3D Structure Click here
O02218 View 3D Structure Click here
O05293 View 3D Structure Click here
O07732 View 3D Structure Click here
O14249 View 3D Structure Click here
O18391 View 3D Structure Click here
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O22977 View 3D Structure Click here
O23220 View 3D Structure Click here
O45707 View 3D Structure Click here
O48789 View 3D Structure Click here
O53327 View 3D Structure Click here
O53622 View 3D Structure Click here
O53697 View 3D Structure Click here
O60062 View 3D Structure Click here
O62202 View 3D Structure Click here
O74430 View 3D Structure Click here
O81299 View 3D Structure Click here
O94437 View 3D Structure Click here
O95870 View 3D Structure Click here
P04634 View 3D Structure Click here
P07000 View 3D Structure Click here
P07098 View 3D Structure Click here
P07099 View 3D Structure Click here
P08465 View 3D Structure Click here
P08910 View 3D Structure Click here
P13001 View 3D Structure Click here
P34163 View 3D Structure Click here
P34913 View 3D Structure Click here
P34914 View 3D Structure Click here
P38139 View 3D Structure Click here
P38295 View 3D Structure Click here
P38571 View 3D Structure Click here
P38796 View 3D Structure Click here
P41879 View 3D Structure Click here
P45524 View 3D Structure Click here
P53208 View 3D Structure Click here
P53219 View 3D Structure Click here
P53264 View 3D Structure Click here
P53750 View 3D Structure Click here
P53925 View 3D Structure Click here
P78898 View 3D Structure Click here
P80299 View 3D Structure Click here
P91143 View 3D Structure Click here
P93732 View 3D Structure Click here
P96811 View 3D Structure Click here
P96935 View 3D Structure Click here
P9WGS3 View 3D Structure Click here
P9WHR3 View 3D Structure Click here
P9WHR5 View 3D Structure Click here
P9WJY9 View 3D Structure Click here
P9WMR9 View 3D Structure Click here
P9WMS1 View 3D Structure Click here
P9WMS3 View 3D Structure Click here
P9WNH5 View 3D Structure Click here
Q02891 View 3D Structure Click here
Q03649 View 3D Structure Click here
Q04623 View 3D Structure Click here
Q058J1 View 3D Structure Click here
Q05AK6 View 3D Structure Click here
Q07646 View 3D Structure Click here
Q08C93 View 3D Structure Click here
Q0DGS8 View 3D Structure Click here
Q0DJJ0 View 3D Structure Click here
Q0J0A4 View 3D Structure Click here
Q0JHI5 View 3D Structure Click here
Q10341 View 3D Structure Click here
Q10KC9 View 3D Structure Click here
Q10QY7 View 3D Structure Click here
Q12385 View 3D Structure Click here
Q15KI9 View 3D Structure Click here
Q18610 View 3D Structure Click here
Q24093 View 3D Structure Click here
Q2FV39 View 3D Structure Click here
Q2G0F0 View 3D Structure Click here
Q2G0F0 View 3D Structure Click here
Q2G0F3 View 3D Structure Click here
Q2G2T4 View 3D Structure Click here
Q33AQ0 View 3D Structure Click here
Q3B8N9 View 3D Structure Click here
Q3U4B4 View 3D Structure Click here
Q42566 View 3D Structure Click here
Q4CQ94 View 3D Structure Click here
Q4CQ96 View 3D Structure Click here
Q4CQ96 View 3D Structure Click here
Q4D8H8 View 3D Structure Click here
Q4D8I0 View 3D Structure Click here
Q4D965 View 3D Structure Click here
Q4E3M8 View 3D Structure Click here
Q4PSG2 View 3D Structure Click here
Q54CU1 View 3D Structure Click here
Q54G24 View 3D Structure Click here
Q54H38 View 3D Structure Click here
Q54H73 View 3D Structure Click here
Q54KZ1 View 3D Structure Click here
Q54M29 View 3D Structure Click here
Q54QK2 View 3D Structure Click here
Q54SY6 View 3D Structure Click here
Q54T91 View 3D Structure Click here
Q54TH2 View 3D Structure Click here
Q54Y48 View 3D Structure Click here
Q54YE0 View 3D Structure Click here
Q54ZA6 View 3D Structure Click here
Q55FN8 View 3D Structure Click here
Q55GK7 View 3D Structure Click here
Q59E63 View 3D Structure Click here
Q59WE9 View 3D Structure Click here
Q5A0I7 View 3D Structure Click here
Q5A948 View 3D Structure Click here
Q5ADY2 View 3D Structure Click here
Q5EB52 View 3D Structure Click here
Q5I0K5 View 3D Structure Click here
Q5JLM9 View 3D Structure Click here
Q5NA00 View 3D Structure Click here
Q5RK23 View 3D Structure Click here
Q5TKP0 View 3D Structure Click here
Q5U191 View 3D Structure Click here
Q5VNP5 View 3D Structure Click here
Q5XIC4 View 3D Structure Click here
Q5XIL6 View 3D Structure Click here
Q64194 View 3D Structure Click here
Q6DRD9 View 3D Structure Click here
Q6I5U7 View 3D Structure Click here
Q6IE26 View 3D Structure Click here
Q6MG55 View 3D Structure Click here
Q6P5P5 View 3D Structure Click here
Q6PC62 View 3D Structure Click here
Q6PE15 View 3D Structure Click here
Q6QA69 View 3D Structure Click here
Q6YZK1 View 3D Structure Click here
Q700D5 View 3D Structure Click here
Q7XI46 View 3D Structure Click here
Q802V6 View 3D Structure Click here
Q80YU0 View 3D Structure Click here
Q850X2 View 3D Structure Click here
Q850X4 View 3D Structure Click here
Q86WA6 View 3D Structure Click here
Q8IL54 View 3D Structure Click here
Q8IUS5 View 3D Structure Click here
Q8K2A6 View 3D Structure Click here
Q8L562 View 3D Structure Click here
Q8LFX7 View 3D Structure Click here
Q8LIH8 View 3D Structure Click here
Q8LN42 View 3D Structure Click here
Q8R0P8 View 3D Structure Click here
Q8R164 View 3D Structure Click here
Q8S3R0 View 3D Structure Click here
Q8TB40 View 3D Structure Click here
Q8VD66 View 3D Structure Click here
Q8WTS1 View 3D Structure Click here
Q8WU67 View 3D Structure Click here
Q93ZN4 View 3D Structure Click here
Q96I13 View 3D Structure Click here
Q96SE0 View 3D Structure Click here
Q9ASW5 View 3D Structure Click here
Q9BL52 View 3D Structure Click here
Q9BV23 View 3D Structure Click here
Q9CQC8 View 3D Structure Click here
Q9DBL9 View 3D Structure Click here
Q9EPB5 View 3D Structure Click here
Q9FJ24 View 3D Structure Click here
Q9FN79 View 3D Structure Click here
Q9FW03 View 3D Structure Click here
Q9FZ33 View 3D Structure Click here
Q9H3Z7 View 3D Structure Click here
Q9H4I8 View 3D Structure Click here
Q9LI62 View 3D Structure Click here
Q9LK01 View 3D Structure Click here
Q9LVU7 View 3D Structure Click here
Q9LYY8 View 3D Structure Click here
Q9M314 View 3D Structure Click here
Q9NQF3 View 3D Structure Click here
Q9NUJ1 View 3D Structure Click here
Q9NZD8 View 3D Structure Click here
Q9QXM0 View 3D Structure Click here
Q9QZC8 View 3D Structure Click here
Q9SD45 View 3D Structure Click here
Q9SF34 View 3D Structure Click here
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Q9SVL9 View 3D Structure Click here
Q9TZ58 View 3D Structure Click here
Q9VKS5 View 3D Structure Click here
Q9VKT2 View 3D Structure Click here
Q9VKT8 View 3D Structure Click here
Q9VP51 View 3D Structure Click here
Q9VZF1 View 3D Structure Click here
Q9W045 View 3D Structure Click here
Q9W047 View 3D Structure Click here
Q9W3R8 View 3D Structure Click here
Q9XID7 View 3D Structure Click here
Q9Y013 View 3D Structure Click here
Q9Z1Q2 View 3D Structure Click here