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2  structures 41  species 0  interactions 44  sequences 1  architecture

Family: CD52 (PF15116)

Summary: CAMPATH-1 antigen

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This is the Wikipedia entry entitled "CD52". More...

CD52 Edit Wikipedia article

CD52
Identifiers
AliasesCD52, CDW52, CD52 molecule, EDDM5, HE5
External IDsOMIM: 114280 HomoloGene: 88652 GeneCards: CD52
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CD52
Genomic location for CD52
Band1p36.11Start26,317,958 bp[1]
End26,320,523 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001803

n/a

RefSeq (protein)

NP_001794

n/a

Location (UCSC)Chr 1: 26.32 – 26.32 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

CAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the CD52 gene.

CD52 is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found on monocytes[3] and dendritic cells.[4] Further, it is found within the male genital tract and is present on the surface of mature sperm cells.

CD52 is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI). Since it is highly negatively charged and present on sperm cells and lymphocytes, it has been conjectured that its function is anti-adhesion, allowing cells to freely move around.[5]

CD52 binds the ITIM (immunoreceptor tyrosine-based inhibitory motif)-bearing sialic acid-binding lectin SIGLEC10.

Clinical significance

It is associated with certain types of lymphoma.[6]

It is the protein targeted by alemtuzumab, a monoclonal antibody used for the treatment of chronic lymphocytic leukemia. A phase III trial into treatment of relapsing-remitting multiple sclerosis showed a reduction in relapse rate, but no statistically significant reduction in accumulated disability, when used as a first-line therapy.[7] However, a sister study looking at patients in whom relapses had occurred despite treatment with interferon beta or glatiramer demonstrated reduction in both relapse rate and accumulated disability. 20% patients randomised to interferon beta 1a had "sustained accumulation of disability" compared with 13% in the alemtuzumab group. .[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169442 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Buggins AG, Mufti GJ, Salisbury J, Codd J, Westwood N, Arno M, Fishlock K, Pagliuca A, Devereux S (September 2002). "Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab". Blood. 100 (5): 1715–20. doi:10.1182/blood.V100.5.1715.h81702001715_1715_1720. PMID 12176892. Archived from the original on 2013-04-14.
  4. ^ Ratzinger G, Reagan JL, Heller G, Busam KJ, Young JW (February 2003). "Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation". Blood. 101 (4): 1422–9. doi:10.1182/blood-2002-04-1093. PMID 12393688.
  5. ^ Hale G, Waldmann H (2000). "From Laboratory to Clinic : The Story of CAM PA TH-1". Methods Mol. Med. 40: 243–66. doi:10.1385/1-59259-076-4:243. ISBN 978-1-59259-076-6. PMID 21337094.
  6. ^ Piccaluga PP, Agostinelli C, Righi S, Zinzani PL, Pileri SA (April 2007). "Expression of CD52 in peripheral T-cell lymphoma". Haematologica. 92 (4): 566–7. doi:10.3324/haematol.10767. PMID 17488672.
  7. ^ Coles AJ, Twyman CL, Arnold DL, Cohen JA, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Miller T, Fisher E, Sandbrink R, Lake SL, Margolin DH, Oyuela P, Panzara MA, Compston DA (November 2012). "Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial". Lancet. 380 (9856): 1829–39. doi:10.1016/S0140-6736(12)61768-1. PMID 23122650.[unreliable medical source?]
  8. ^ Cohen, Jeffrey; Coles A; Arnold D (24 November 2012). "Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial". The Lancet. 380 (9856): 1819–1828. doi:10.1016/S0140-6736(12)61769-3. PMID 23122652. Retrieved 28 December 2012.

External links


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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

CAMPATH-1 antigen Provide feedback

No Pfam abstract.

This tab holds annotation information from the InterPro database.

InterPro entry IPR026643

CAMPATH-1 antigen (also known as CD52) is a very small glycosylphosphatidylinositol (GPI)-anchored glycoprotein present in lymphocytes , male reproductive tracts and female cumulus cells [PUBMED:1711975, PUBMED:7688956, PUBMED:8418821, PUBMED:9464849, PUBMED:18647288]. CD52 on the lymphocyte membrane surface induces regulatory T cells with immunosuppressive activities [PUBMED:16797237]. In the male reproductive tract, CD52 may protect sperm function from complement attack if antisperm antibody is generated in the female reproductive tracts [PUBMED:22386526]. It has also been suggested that CD52 has some functional roles around fertilisation in females as well as in males [PUBMED:18647288].

Domain organisation

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Alignments

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(44)
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(75)
Meta
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RP15
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RP35
(1)
RP55
(5)
RP75
(6)
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  Seed
(10)
Full
(44)
Representative proteomes UniProt
(58)
NCBI
(75)
Meta
(0)
RP15
(0)
RP35
(1)
RP55
(5)
RP75
(6)
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Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

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Curation View help on the curation process

Seed source: Jackhmmer:P31358
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Eberhardt R , Coggill P , Hetherington K
Number in seed: 10
Number in full: 44
Average length of the domain: 44.60 aa
Average identity of full alignment: 43 %
Average coverage of the sequence by the domain: 61.74 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 34.7 33.9
Noise cut-off 23.1 21.0
Model length: 44
Family (HMM) version: 7
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the CD52 domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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