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185  structures 2442  species 0  interactions 26138  sequences 421  architectures

Family: DSPc (PF00782)

Summary: Dual specificity phosphatase, catalytic domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Protein tyrosine phosphatase". More...

Protein tyrosine phosphatase Edit Wikipedia article

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Dual specificity phosphatase, catalytic domain Provide feedback

Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region [2].

Literature references

  1. Fauman EB, Saper MA; , Trends Biochem Sci 1996;21:413-417.: Structure and function of the protein tyrosine phosphatases. PUBMED:8987394 EPMC:8987394

  2. Yuvaniyama J, Denu JM, Dixon JE, Saper MA; , Science 1996;272:1328-1331.: Crystal structure of the dual specificity protein phosphatase VHR. PUBMED:8650541 EPMC:8650541


Internal database links

External database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Phosphatase (CL0031), which has the following description:

This family includes tyrosine and dual specificity phosphatase enzymes.

The clan contains the following 16 members:

CDKN3 DSPc DSPn DUF442 Init_tRNA_PT LMWPc Myotub-related NleF_casp_inhib PTPlike_phytase PTS_IIB Rhodanese Ssu72 Syja_N Y_phosphatase Y_phosphatase2 Y_phosphatase3

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(22)
Full
(26138)
Representative proteomes UniProt
(53324)
RP15
(5022)
RP35
(11898)
RP55
(22247)
RP75
(29753)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(22)
Full
(26138)
Representative proteomes UniProt
(53324)
RP15
(5022)
RP35
(11898)
RP55
(22247)
RP75
(29753)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(22)
Full
(26138)
Representative proteomes UniProt
(53324)
RP15
(5022)
RP35
(11898)
RP55
(22247)
RP75
(29753)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Alignment kindly provided by SMART
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: SMART
Number in seed: 22
Number in full: 26138
Average length of the domain: 126.70 aa
Average identity of full alignment: 22 %
Average coverage of the sequence by the domain: 28.37 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 33.5 33.5
Trusted cut-off 33.5 33.5
Noise cut-off 33.4 33.4
Model length: 133
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the DSPc domain has been found. There are 185 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K3I9 View 3D Structure Click here
A0A0G2K9N1 View 3D Structure Click here
A0A0G2KB18 View 3D Structure Click here
A0A0G2KHQ4 View 3D Structure Click here
A0A0R0IF22 View 3D Structure Click here
A0A0R0JYL8 View 3D Structure Click here
A0A0R0KQX0 View 3D Structure Click here
A0A0R4I9C9 View 3D Structure Click here
A0A0R4IE73 View 3D Structure Click here
A0A0R4IS50 View 3D Structure Click here
A0A0R4IVA4 View 3D Structure Click here
A0A140LFT0 View 3D Structure Click here
A0A1D6EGX8 View 3D Structure Click here
A0A1D6EIJ0 View 3D Structure Click here
A0A1D6FVL3 View 3D Structure Click here
A0A1D6G824 View 3D Structure Click here
A0A1D6HIH3 View 3D Structure Click here
A0A1D6J5K0 View 3D Structure Click here
A0A1D6JKL8 View 3D Structure Click here
A0A1D6LHJ0 View 3D Structure Click here
A0A1D6LHJ1 View 3D Structure Click here
A0A1D6MAJ2 View 3D Structure Click here
A0A1D6MRW0 View 3D Structure Click here
A0A1D6ND14 View 3D Structure Click here
A0A1D8PDD7 View 3D Structure Click here
A0A1D8PMG3 View 3D Structure Click here
A0A1D8PQQ6 View 3D Structure Click here
A0A1D8PSH7 View 3D Structure Click here
A0A2R8PZ11 View 3D Structure Click here
A0A2R8Q350 View 3D Structure Click here
A0A2R8Q8Q6 View 3D Structure Click here
A0A2R8QCJ8 View 3D Structure Click here
A0A2R8QLM5 View 3D Structure Click here
A0A2R8QM14 View 3D Structure Click here
A0A2R8QMW0 View 3D Structure Click here
A0A2R8QPP3 View 3D Structure Click here
A0A2R8RMV8 View 3D Structure Click here
A0A2R8RXU6 View 3D Structure Click here
A0JMM1 View 3D Structure Click here
A1EC97 View 3D Structure Click here
A1L1R5 View 3D Structure Click here
A1L293 View 3D Structure Click here
A2A3K4 View 3D Structure Click here
A4D256 View 3D Structure Click here
A4HSF4 View 3D Structure Click here
A4HTG0 View 3D Structure Click here
A4HZ69 View 3D Structure Click here
A4I165 View 3D Structure Click here
A4I2Z0 View 3D Structure Click here
A4I317 View 3D Structure Click here
A4I390 View 3D Structure Click here
A4I3F4 View 3D Structure Click here
A4I7L8 View 3D Structure Click here
A4I9Z1 View 3D Structure Click here
A4IC04 View 3D Structure Click here
A8DZH6 View 3D Structure Click here
A8E7M1 View 3D Structure Click here
A8E7M1 View 3D Structure Click here
A8WGA2 View 3D Structure Click here
B0S6R2 View 3D Structure Click here
B3DHB2 View 3D Structure Click here
B4F7B7 View 3D Structure Click here
B4FLX8 View 3D Structure Click here
B4FN89 View 3D Structure Click here
B6T3N5 View 3D Structure Click here
B7EQL6 View 3D Structure Click here
B7ZD10 View 3D Structure Click here
B8JLI8 View 3D Structure Click here
C0HGP0 View 3D Structure Click here
C0PFH1 View 3D Structure Click here
C4IZF7 View 3D Structure Click here
C4JAJ1 View 3D Structure Click here
C6SYZ7 View 3D Structure Click here
D3ZAQ8 View 3D Structure Click here
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D3ZC16 View 3D Structure Click here
D3ZH30 View 3D Structure Click here
D3ZH31 View 3D Structure Click here
D3ZNK9 View 3D Structure Click here
D3ZRL3 View 3D Structure Click here
D3ZRM0 View 3D Structure Click here
D4A3W6 View 3D Structure Click here
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E7EXY0 View 3D Structure Click here
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E7FBM8 View 3D Structure Click here
E7FH10 View 3D Structure Click here
E9PSZ9 View 3D Structure Click here
E9QCC5 View 3D Structure Click here
E9QD92 View 3D Structure Click here
E9QHS4 View 3D Structure Click here
F1LWM1 View 3D Structure Click here
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F1M567 View 3D Structure Click here
F1QCJ9 View 3D Structure Click here
F1QE17 View 3D Structure Click here
F1QE47 View 3D Structure Click here
F1QVZ9 View 3D Structure Click here
F1QWM2 View 3D Structure Click here
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F1R448 View 3D Structure Click here
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F4IYM6 View 3D Structure Click here
F4J117 View 3D Structure Click here
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I1JIH0 View 3D Structure Click here
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I1KPV3 View 3D Structure Click here
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I1MV44 View 3D Structure Click here
I1N525 View 3D Structure Click here
I1N8Q9 View 3D Structure Click here
I1N9F9 View 3D Structure Click here
I1NFD3 View 3D Structure Click here
I1NHQ7 View 3D Structure Click here
I2HA91 View 3D Structure Click here
K7K355 View 3D Structure Click here
K7K7C7 View 3D Structure Click here
K7KDH1 View 3D Structure Click here
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K7KQT9 View 3D Structure Click here
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K7LLV8 View 3D Structure Click here
K7MPD0 View 3D Structure Click here
K7MTE7 View 3D Structure Click here
K7MWV8 View 3D Structure Click here
K7US54 View 3D Structure Click here
M0R3K8 View 3D Structure Click here
M0R587 View 3D Structure Click here
M9PI51 View 3D Structure Click here
O09112 View 3D Structure Click here
O13453 View 3D Structure Click here
O13632 View 3D Structure Click here
O54838 View 3D Structure Click here
O55236 View 3D Structure Click here
O60729 View 3D Structure Click here
O60942 View 3D Structure Click here
O75319 View 3D Structure Click here
O77334 View 3D Structure Click here
O95147 View 3D Structure Click here
P0C089 View 3D Structure Click here
P0C595 View 3D Structure Click here
P28562 View 3D Structure Click here
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P34442 View 3D Structure Click here
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Q00684 View 3D Structure Click here
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Q05922 View 3D Structure Click here
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Q22707 View 3D Structure Click here
Q29RA3 View 3D Structure Click here
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Q2RAU9 View 3D Structure Click here
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Q2YDV1 View 3D Structure Click here
Q4CN18 View 3D Structure Click here
Q4CNG9 View 3D Structure Click here
Q4CPJ1 View 3D Structure Click here
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Q4CYP5 View 3D Structure Click here
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Q4D341 View 3D Structure Click here
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Q4DCA5 View 3D Structure Click here
Q4DHB5 View 3D Structure Click here
Q4DL55 View 3D Structure Click here
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Q4DLZ8 View 3D Structure Click here
Q4DMD9 View 3D Structure Click here
Q4DNY4 View 3D Structure Click here
Q4DPP4 View 3D Structure Click here
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Q4DR43 View 3D Structure Click here
Q4DS67 View 3D Structure Click here
Q4DT47 View 3D Structure Click here
Q4DTS7 View 3D Structure Click here
Q4E1Q9 View 3D Structure Click here
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Q4G0W2 View 3D Structure Click here
Q4KM79 View 3D Structure Click here
Q54CK7 View 3D Structure Click here
Q54N84 View 3D Structure Click here
Q54R42 View 3D Structure Click here
Q54T76 View 3D Structure Click here
Q54Y32 View 3D Structure Click here
Q550K8 View 3D Structure Click here
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Q55BI8 View 3D Structure Click here
Q55CS7 View 3D Structure Click here
Q55CS8 View 3D Structure Click here
Q55E39 View 3D Structure Click here
Q566R7 View 3D Structure Click here
Q59NH8 View 3D Structure Click here
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Q60969 View 3D Structure Click here
Q62767 View 3D Structure Click here
Q63340 View 3D Structure Click here
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Q64346 View 3D Structure Click here
Q64623 View 3D Structure Click here
Q655C5 View 3D Structure Click here
Q66GT5 View 3D Structure Click here
Q68J44 View 3D Structure Click here
Q6AXW7 View 3D Structure Click here
Q6DBR5 View 3D Structure Click here
Q6GQT0 View 3D Structure Click here
Q6NKR2 View 3D Structure Click here
Q6NN85 View 3D Structure Click here
Q6NT99 View 3D Structure Click here
Q6NX92 View 3D Structure Click here
Q6NXK5 View 3D Structure Click here
Q6NY98 View 3D Structure Click here
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Q6PBT4 View 3D Structure Click here
Q6PCP3 View 3D Structure Click here
Q6PFY9 View 3D Structure Click here
Q6Z648 View 3D Structure Click here
Q75QN6 View 3D Structure Click here
Q76I76 View 3D Structure Click here
Q76I79 View 3D Structure Click here
Q78EG7 View 3D Structure Click here
Q7EYM9 View 3D Structure Click here
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Q7XC53 View 3D Structure Click here
Q84JU4 View 3D Structure Click here
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Q93096 View 3D Structure Click here
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Q99956 View 3D Structure Click here
Q99N11 View 3D Structure Click here
Q9BV47 View 3D Structure Click here
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Q9BY84 View 3D Structure Click here
Q9C5S1 View 3D Structure Click here
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Q9D700 View 3D Structure Click here
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Q9DAR2 View 3D Structure Click here
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Q9ESS0 View 3D Structure Click here
Q9FEB5 View 3D Structure Click here
Q9GV71 View 3D Structure Click here
Q9H1R2 View 3D Structure Click here
Q9H596 View 3D Structure Click here
Q9JIM4 View 3D Structure Click here
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Q9TY00 View 3D Structure Click here
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