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2  structures 1486  species 0  interactions 5465  sequences 175  architectures

Family: FSH1 (PF03959)

Summary: Serine hydrolase (FSH1)

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Serine hydrolase (FSH1) Provide feedback

This is a family of serine hydrolases [1].

Literature references

  1. Quevillon-Cheruel S, Leulliot N, Graille M, Hervouet N, Coste F, Benedetti H, Zelwer C, Janin J, Van Tilbeurgh H; , Protein Sci 2005;14:1350-1356.: Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family. PUBMED:15802654 EPMC:15802654


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR005645

This domain can be found in budding yeast Fsh1/2/3, fission yeast Dfr1 and the human OVCA2 protein. Fsh1/2/3 are putative serine hydrolases [ PUBMED:14645503 ]. Dfr1 is a dihydrofolate reductase (DHFR) [ PUBMED:8088538 ]. OVCA2 is a putative serine-hydrolase that has been linked to cancers [ PUBMED:16368187 ]. Proteins containing this domain also includes Aspergillus terreus esterase LovG, which catalyzes the release of covalently bound dihydromonacolin L from LovB during lovastatin biosynthesis [ PUBMED:23653178 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(46)
Full
(5465)
Representative proteomes UniProt
(11883)
RP15
(777)
RP35
(2295)
RP55
(3937)
RP75
(5761)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(46)
Full
(5465)
Representative proteomes UniProt
(11883)
RP15
(777)
RP35
(2295)
RP55
(3937)
RP75
(5761)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(46)
Full
(5465)
Representative proteomes UniProt
(11883)
RP15
(777)
RP35
(2295)
RP55
(3937)
RP75
(5761)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: DOMO:DM04042;
Previous IDs: DUF341;
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD , Bateman A , Mistry J , Wood V
Number in seed: 46
Number in full: 5465
Average length of the domain: 206.20 aa
Average identity of full alignment: 21 %
Average coverage of the sequence by the domain: 67.81 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.4 20.4
Trusted cut-off 20.4 20.4
Noise cut-off 20.3 20.3
Model length: 212
Family (HMM) version: 15
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the FSH1 domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0R0I1K2 View 3D Structure Click here
A0A178UQA6 View 3D Structure Click here
A0A1D6E9I3 View 3D Structure Click here
A0A1D6E9J3 View 3D Structure Click here
A0A1D6F4P0 View 3D Structure Click here
A0A1D6INZ6 View 3D Structure Click here
A0A1D6KDA9 View 3D Structure Click here
A0A1D8PNX1 View 3D Structure Click here
A0A1P8B8P6 View 3D Structure Click here
A0A1P8B8P6 View 3D Structure Click here
A4I8D6 View 3D Structure Click here
I1JC85 View 3D Structure Click here
I1JGX4 View 3D Structure Click here
I1JK28 View 3D Structure Click here
I1MAY2 View 3D Structure Click here
I1N8I3 View 3D Structure Click here
K7K6C0 View 3D Structure Click here
K7N2K1 View 3D Structure Click here
O13897 View 3D Structure Click here
O76462 View 3D Structure Click here
P36591 View 3D Structure Click here
P38777 View 3D Structure Click here
Q05015 View 3D Structure Click here
Q18169 View 3D Structure Click here
Q2QNJ3 View 3D Structure Click here
Q4CVK5 View 3D Structure Click here
Q4DAB1 View 3D Structure Click here
Q503Y4 View 3D Structure Click here
Q55D01 View 3D Structure Click here
Q55D01 View 3D Structure Click here
Q5ADX4 View 3D Structure Click here
Q5N7J6 View 3D Structure Click here
Q7XV53 View 3D Structure Click here
Q8LIG3 View 3D Structure Click here
Q8WZ82 View 3D Structure Click here
Q94AC1 View 3D Structure Click here
Q99369 View 3D Structure Click here
Q9D7E3 View 3D Structure Click here
Q9VDL1 View 3D Structure Click here