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54  structures 2267  species 0  interactions 24410  sequences 377  architectures

Family: Lipase_GDSL (PF00657)

Summary: GDSL-like Lipase/Acylhydrolase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

GDSL-like Lipase/Acylhydrolase Provide feedback

No Pfam abstract.

Literature references

  1. Upton C, Buckley JT; , Trends Biochem Sci 1995;20:178-179.: A new family of lipolytic enzymes? PUBMED:7610479 EPMC:7610479

  2. Molgaard A, Kauppinen S, Larsen S; , Structure Fold Des 2000;8:373-383.: Rhamnogalacturonan acetylesterase elucidates the structure and function of a new family of hydrolases. PUBMED:10801485 EPMC:10801485


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001087

GDSL esterases and lipases are hydrolytic enzymes with multifunctional properties [ PUBMED:15522763 ]. This new subclass of lipolytic enzymes possesses a distinct GDSL sequence motif different from the GxSxG motif found in many lipases [ PUBMED:7610479 ]. Members include; Aeromonas hydrophila lipase, Vibrio mimicus arylesterase, Vibrio parahaemolyticus thermolabile haemolysin, rabbit phospholipase (AdRab-B), and Brassica napus anter-specific proline-rich protein. 3D structures of several enzymes of this family revealed several beta-strands and alpha-helices arranged in alternating order and the substrate-binding pocket between the central beta-strand and long alpha-helix appears to be highly flexible [ PUBMED:19555778 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan SGNH_hydrolase (CL0264), which has the following description:

This superfamily contains a diversity of hydrolytic enzyme activities.

The clan contains the following 16 members:

ALGX DHHW DltD DUF1574 DUF459 DUF4886 GSCFA Hema_esterase Lipase_GDSL Lipase_GDSL_2 Lipase_GDSL_3 Lipase_GDSL_lke OSK PC-Esterase SASA SGNH

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(67)
Full
(24410)
Representative proteomes UniProt
(43477)
RP15
(2735)
RP35
(12079)
RP55
(20226)
RP75
(28025)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(67)
Full
(24410)
Representative proteomes UniProt
(43477)
RP15
(2735)
RP35
(12079)
RP55
(20226)
RP75
(28025)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(67)
Full
(24410)
Representative proteomes UniProt
(43477)
RP15
(2735)
RP35
(12079)
RP55
(20226)
RP75
(28025)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite & Pfam-B_543 (Release 7.5)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A , Mistry J , Molgaard A
Number in seed: 67
Number in full: 24410
Average length of the domain: 275.70 aa
Average identity of full alignment: 20 %
Average coverage of the sequence by the domain: 77.45 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null --hand HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.6 23.6
Trusted cut-off 23.6 23.6
Noise cut-off 23.5 23.5
Model length: 224
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Lipase_GDSL domain has been found. There are 54 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K753 View 3D Structure Click here
A0A0N7KHK3 View 3D Structure Click here
A0A0N7KJI1 View 3D Structure Click here
A0A0N7KL21 View 3D Structure Click here
A0A0N7KTI3 View 3D Structure Click here
A0A0P0UZM4 View 3D Structure Click here
A0A0P0V0B1 View 3D Structure Click here
A0A0P0V0B8 View 3D Structure Click here
A0A0P0V5W7 View 3D Structure Click here
A0A0P0V5X7 View 3D Structure Click here
A0A0P0V5Y5 View 3D Structure Click here
A0A0P0V5Y6 View 3D Structure Click here
A0A0P0VD07 View 3D Structure Click here
A0A0P0VIN4 View 3D Structure Click here
A0A0P0VMR3 View 3D Structure Click here
A0A0P0VMT8 View 3D Structure Click here
A0A0P0VP97 View 3D Structure Click here
A0A0P0VYH5 View 3D Structure Click here
A0A0P0VYI8 View 3D Structure Click here
A0A0P0VYL7 View 3D Structure Click here
A0A0P0VYL8 View 3D Structure Click here
A0A0P0WJ82 View 3D Structure Click here
A0A0P0WP83 View 3D Structure Click here
A0A0P0WP94 View 3D Structure Click here
A0A0P0WSD0 View 3D Structure Click here
A0A0P0WUU7 View 3D Structure Click here
A0A0P0XTQ3 View 3D Structure Click here
A0A0P0XTS4 View 3D Structure Click here
A0A0P0XUK1 View 3D Structure Click here
A0A0P0XUR0 View 3D Structure Click here
A0A0R0E7N6 View 3D Structure Click here
A0A0R0EEL9 View 3D Structure Click here
A0A0R0ELP2 View 3D Structure Click here
A0A0R0ENU8 View 3D Structure Click here
A0A0R0ES86 View 3D Structure Click here
A0A0R0ETP1 View 3D Structure Click here
A0A0R0EUZ8 View 3D Structure Click here
A0A0R0F156 View 3D Structure Click here
A0A0R0FIS4 View 3D Structure Click here
A0A0R0FNN3 View 3D Structure Click here
A0A0R0FPW7 View 3D Structure Click here
A0A0R0FW44 View 3D Structure Click here
A0A0R0FWM5 View 3D Structure Click here
A0A0R0G2Z5 View 3D Structure Click here
A0A0R0G8M1 View 3D Structure Click here
A0A0R0G9Q7 View 3D Structure Click here
A0A0R0GGE2 View 3D Structure Click here
A0A0R0GGV6 View 3D Structure Click here
A0A0R0GJX5 View 3D Structure Click here
A0A0R0GQ66 View 3D Structure Click here
A0A0R0H2T2 View 3D Structure Click here
A0A0R0H7J4 View 3D Structure Click here
A0A0R0HC59 View 3D Structure Click here
A0A0R0ICE4 View 3D Structure Click here
A0A0R0ITU9 View 3D Structure Click here
A0A0R0JAP7 View 3D Structure Click here
A0A0R0JLP6 View 3D Structure Click here
A0A0R0JMJ5 View 3D Structure Click here
A0A0R0JMW1 View 3D Structure Click here
A0A0R0JPA2 View 3D Structure Click here
A0A0R0JPB9 View 3D Structure Click here
A0A0R0KD58 View 3D Structure Click here
A0A0R0KG45 View 3D Structure Click here
A0A0R0KPT5 View 3D Structure Click here
A0A0R0KV91 View 3D Structure Click here
A0A0R0L0P9 View 3D Structure Click here
A0A0R0L2E0 View 3D Structure Click here
A0A0R0L9L8 View 3D Structure Click here
A0A0R4J3B7 View 3D Structure Click here
A0A0R4J3X1 View 3D Structure Click here
A0A0R4J4B6 View 3D Structure Click here
A0A0R4J4E2 View 3D Structure Click here
A0A0R4J4Z9 View 3D Structure Click here
A0A0R4J560 View 3D Structure Click here
A0A1D6EI14 View 3D Structure Click here
A0A1D6EZ92 View 3D Structure Click here
A0A1D6F5M2 View 3D Structure Click here
A0A1D6FEC1 View 3D Structure Click here
A0A1D6FEC1 View 3D Structure Click here
A0A1D6FGP4 View 3D Structure Click here
A0A1D6FGP4 View 3D Structure Click here
A0A1D6FGP6 View 3D Structure Click here
A0A1D6FGP7 View 3D Structure Click here
A0A1D6FGP9 View 3D Structure Click here
A0A1D6FR26 View 3D Structure Click here
A0A1D6FU83 View 3D Structure Click here
A0A1D6G2V6 View 3D Structure Click here
A0A1D6GRY9 View 3D Structure Click here
A0A1D6GUF2 View 3D Structure Click here
A0A1D6GWL4 View 3D Structure Click here
A0A1D6GWL5 View 3D Structure Click here
A0A1D6GWL6 View 3D Structure Click here
A0A1D6GXQ4 View 3D Structure Click here
A0A1D6H318 View 3D Structure Click here
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A0A1D6H554 View 3D Structure Click here
A0A1D6H5J4 View 3D Structure Click here
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A0A1D6HJU1 View 3D Structure Click here
A0A1D6I0K7 View 3D Structure Click here
A0A1D6IL11 View 3D Structure Click here
A0A1D6IPR9 View 3D Structure Click here
A0A1D6IXP5 View 3D Structure Click here
A0A1D6JC13 View 3D Structure Click here
A0A1D6JD00 View 3D Structure Click here
A0A1D6KL38 View 3D Structure Click here
A0A1D6KUP9 View 3D Structure Click here
A0A1D6LCF0 View 3D Structure Click here
A0A1D6LE56 View 3D Structure Click here
A0A1D6LE69 View 3D Structure Click here
A0A1D6LJ65 View 3D Structure Click here
A0A1D6LTD6 View 3D Structure Click here
A0A1D6LZD5 View 3D Structure Click here
A0A1D6M0R6 View 3D Structure Click here
A0A1D6M3T8 View 3D Structure Click here
A0A1D6M685 View 3D Structure Click here
A0A1D6M7Q9 View 3D Structure Click here
A0A1D6MA21 View 3D Structure Click here
A0A1D6MFC1 View 3D Structure Click here
A0A1D6MFV1 View 3D Structure Click here
A0A1D6MFV1 View 3D Structure Click here
A0A1D6MFX4 View 3D Structure Click here
A0A1D6MI06 View 3D Structure Click here
A0A1D6MPE2 View 3D Structure Click here
A0A1D6MPE2 View 3D Structure Click here
A0A1D6MSG1 View 3D Structure Click here
A0A1D6NC54 View 3D Structure Click here
A0A1D6NCD9 View 3D Structure Click here
A0A1D6NHH0 View 3D Structure Click here
A0A1D6NHH1 View 3D Structure Click here
A0A1D6NHH2 View 3D Structure Click here
A0A1D6NMW1 View 3D Structure Click here
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A0A1D6NV48 View 3D Structure Click here
A0A1D6NY29 View 3D Structure Click here
A0A1D6P0Z7 View 3D Structure Click here
A0A1D6P1Q4 View 3D Structure Click here
A0A1D6P498 View 3D Structure Click here
A0A1D6P593 View 3D Structure Click here
A0A1D6PBX8 View 3D Structure Click here
A0A1D6Q519 View 3D Structure Click here
A0A1D6Q6S5 View 3D Structure Click here
A0A1D6QGX6 View 3D Structure Click here
A0A1D6QND1 View 3D Structure Click here
A0A1P8B6B7 View 3D Structure Click here
A0A1X7YEC3 View 3D Structure Click here
A0A368UGZ7 View 3D Structure Click here
A0A368UH49 View 3D Structure Click here
A0A368UH71 View 3D Structure Click here
A2ZVC7 View 3D Structure Click here
B3H5G5 View 3D Structure Click here
B3H6L2 View 3D Structure Click here
B4F7W6 View 3D Structure Click here
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B4FA08 View 3D Structure Click here
B4FB92 View 3D Structure Click here
B4FF69 View 3D Structure Click here
B4FFU8 View 3D Structure Click here
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B4FL93 View 3D Structure Click here
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B4FSK3 View 3D Structure Click here
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B4FV62 View 3D Structure Click here
B4FXJ5 View 3D Structure Click here
B4FYB6 View 3D Structure Click here
B4FZ56 View 3D Structure Click here
B4FZ87 View 3D Structure Click here
B4G013 View 3D Structure Click here
B4G053 View 3D Structure Click here
B4G1K8 View 3D Structure Click here
B6SRX6 View 3D Structure Click here
B6SUN1 View 3D Structure Click here
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B7F8G8 View 3D Structure Click here
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B8A026 View 3D Structure Click here
B8A072 View 3D Structure Click here
C0HHC3 View 3D Structure Click here
C0HIS1 View 3D Structure Click here
C0P557 View 3D Structure Click here
C0P5I0 View 3D Structure Click here
C0P8E3 View 3D Structure Click here
C0P8R6 View 3D Structure Click here
C0PDY5 View 3D Structure Click here
C0PFD7 View 3D Structure Click here
C0PM87 View 3D Structure Click here
C4J4U3 View 3D Structure Click here
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C6TG75 View 3D Structure Click here
C6TNU9 View 3D Structure Click here
C7IWA6 View 3D Structure Click here
C7IWN0 View 3D Structure Click here
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I1J668 View 3D Structure Click here
I1J923 View 3D Structure Click here
I1JAF0 View 3D Structure Click here
I1JCC4 View 3D Structure Click here
I1JCF0 View 3D Structure Click here
I1JCF4 View 3D Structure Click here
I1JCV7 View 3D Structure Click here
I1JEL1 View 3D Structure Click here
I1JHI4 View 3D Structure Click here
I1JHW3 View 3D Structure Click here
I1JIF3 View 3D Structure Click here
I1JIH2 View 3D Structure Click here
I1JLX2 View 3D Structure Click here
I1JPB1 View 3D Structure Click here
I1JPZ9 View 3D Structure Click here
I1JR35 View 3D Structure Click here
I1JRU3 View 3D Structure Click here
I1JRU4 View 3D Structure Click here
I1JRU5 View 3D Structure Click here
I1JRU6 View 3D Structure Click here
I1JRW7 View 3D Structure Click here
I1JT13 View 3D Structure Click here
I1JT14 View 3D Structure Click here
I1JWU3 View 3D Structure Click here
I1JXP1 View 3D Structure Click here
I1JZD2 View 3D Structure Click here
I1JZD3 View 3D Structure Click here
I1JZN9 View 3D Structure Click here
I1K075 View 3D Structure Click here
I1K1F8 View 3D Structure Click here
I1K2M9 View 3D Structure Click here
I1K443 View 3D Structure Click here
I1K7I4 View 3D Structure Click here
I1KCT9 View 3D Structure Click here
I1KEX1 View 3D Structure Click here
I1KF33 View 3D Structure Click here
I1KFY5 View 3D Structure Click here
I1KGH3 View 3D Structure Click here
I1KHH2 View 3D Structure Click here
I1KHH3 View 3D Structure Click here
I1KI01 View 3D Structure Click here
I1KLR4 View 3D Structure Click here
I1KSX3 View 3D Structure Click here
I1KV03 View 3D Structure Click here
I1KXZ3 View 3D Structure Click here
I1L1V1 View 3D Structure Click here
I1L611 View 3D Structure Click here
I1L8J6 View 3D Structure Click here
I1L9B6 View 3D Structure Click here
I1L9H0 View 3D Structure Click here
I1LBF1 View 3D Structure Click here
I1LBT0 View 3D Structure Click here
I1LCT8 View 3D Structure Click here
I1LHI5 View 3D Structure Click here
I1LTQ0 View 3D Structure Click here
I1LX38 View 3D Structure Click here
I1LX46 View 3D Structure Click here
I1LXW5 View 3D Structure Click here
I1LYS7 View 3D Structure Click here
I1LZI9 View 3D Structure Click here
I1M046 View 3D Structure Click here
I1M1M0 View 3D Structure Click here
I1M1M2 View 3D Structure Click here
I1M1V3 View 3D Structure Click here
I1M1W0 View 3D Structure Click here
I1M1X6 View 3D Structure Click here
I1M5F3 View 3D Structure Click here
I1M7K0 View 3D Structure Click here
I1MA39 View 3D Structure Click here
I1MA40 View 3D Structure Click here
I1MC21 View 3D Structure Click here
I1MC22 View 3D Structure Click here
I1MEP1 View 3D Structure Click here
I1MER1 View 3D Structure Click here
I1MEY3 View 3D Structure Click here
I1MEY4 View 3D Structure Click here
I1MJE9 View 3D Structure Click here
I1MJF0 View 3D Structure Click here
I1MK58 View 3D Structure Click here
I1MKN6 View 3D Structure Click here
I1MLS6 View 3D Structure Click here
I1MLS7 View 3D Structure Click here
I1MMZ0 View 3D Structure Click here
I1MN26 View 3D Structure Click here
I1MTU3 View 3D Structure Click here
I1MUL7 View 3D Structure Click here
I1MY46 View 3D Structure Click here
I1MY47 View 3D Structure Click here
I1MY48 View 3D Structure Click here
I1MY49 View 3D Structure Click here
I1N0M8 View 3D Structure Click here
I1N498 View 3D Structure Click here
I1N5R1 View 3D Structure Click here
I1N6T6 View 3D Structure Click here
I1N6U2 View 3D Structure Click here
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I1N6W2 View 3D Structure Click here
I1NBP7 View 3D Structure Click here
I1NCF1 View 3D Structure Click here
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I1NCT6 View 3D Structure Click here
K7DYE2 View 3D Structure Click here
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K7KAA0 View 3D Structure Click here
K7KHQ5 View 3D Structure Click here
K7KPP3 View 3D Structure Click here
K7KSL6 View 3D Structure Click here
K7KVU0 View 3D Structure Click here
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K7KX97 View 3D Structure Click here
K7KY01 View 3D Structure Click here
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K7LBM1 View 3D Structure Click here
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K7V930 View 3D Structure Click here
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O01300 View 3D Structure Click here
O22918 View 3D Structure Click here
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O23469 View 3D Structure Click here
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O35298 View 3D Structure Click here
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O64468 View 3D Structure Click here
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O65921 View 3D Structure Click here
O74648 View 3D Structure Click here
O80470 View 3D Structure Click here
O80522 View 3D Structure Click here
P0ADA1 View 3D Structure Click here
P0C8Z7 View 3D Structure Click here
P0DI15 View 3D Structure Click here
P0DKJ6 View 3D Structure Click here
P28039 View 3D Structure Click here
P40602 View 3D Structure Click here
P41734 View 3D Structure Click here
Q0D3T0 View 3D Structure Click here
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Q10MG0 View 3D Structure Click here
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