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1  structure 299  species 0  interactions 10956  sequences 178  architectures

Family: PC-Esterase (PF13839)

Summary: GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Provide feedback

The PC-Esterase family [1] is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1 [2] animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily [1]. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins [1]. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity [1]. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes [1]. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain [1].

Literature references

  1. Anantharaman V, Aravind L;, Biol Direct. 2010;5:1.: Novel eukaryotic enzymes modifying cell-surface biopolymers. PUBMED:20056006 EPMC:20056006

  2. Bischoff V, Selbig J, Scheible WR;, Plant Signal Behav. 2010; [Epub ahead of print]: Involvement of TBL/DUF231 proteins into cell wall biology. PUBMED:20657172 EPMC:20657172

  3. Lefebvre V, Fortabat MN, Ducamp A, North HM, Maia-Grondard A, Trouverie J, Boursiac Y, Mouille G, Durand-Tardif M;, PLoS One. 2011;6:e16645.: ESKIMO1 disruption in Arabidopsis alters vascular tissue and impairs water transport. PUBMED:21408051 EPMC:21408051


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR026057

The PC-Esterase family [ PUBMED:20056006 ] is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1 [ PUBMED:20657172 , PUBMED:21408051 ], animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily [ PUBMED:20056006 ]. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins [ PUBMED:20056006 , PUBMED:21408051 ]. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity [ PUBMED:20056006 ]. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes [ PUBMED:20056006 ]. The plant family with PMR5, ESK1, TBL3 etc have an N-terminal C rich potential sugar binding domain followed by the PC-Esterase domain [ PUBMED:20056006 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan SGNH_hydrolase (CL0264), which has the following description:

This superfamily contains a diversity of hydrolytic enzyme activities.

The clan contains the following 16 members:

ALGX DHHW DltD DUF1574 DUF459 DUF4886 GSCFA Hema_esterase Lipase_GDSL Lipase_GDSL_2 Lipase_GDSL_3 Lipase_GDSL_lke OSK PC-Esterase SASA SGNH

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(182)
Full
(10956)
Representative proteomes UniProt
(16421)
RP15
(988)
RP35
(5687)
RP55
(9128)
RP75
(12046)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(182)
Full
(10956)
Representative proteomes UniProt
(16421)
RP15
(988)
RP35
(5687)
RP55
(9128)
RP75
(12046)
Alignment:
Format:
Order:
Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(182)
Full
(10956)
Representative proteomes UniProt
(16421)
RP15
(988)
RP35
(5687)
RP55
(9128)
RP75
(12046)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Manual
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Anantharaman V
Number in seed: 182
Number in full: 10956
Average length of the domain: 242.40 aa
Average identity of full alignment: 28 %
Average coverage of the sequence by the domain: 62.42 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.0 27.0
Noise cut-off 26.9 26.9
Model length: 283
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PC-Esterase domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JW48 View 3D Structure Click here
A0A0N7KD08 View 3D Structure Click here
A0A0N7KT51 View 3D Structure Click here
A0A0P0V610 View 3D Structure Click here
A0A0P0WBE1 View 3D Structure Click here
A0A0P0WL81 View 3D Structure Click here
A0A0P0WUJ3 View 3D Structure Click here
A0A0P0WV04 View 3D Structure Click here
A0A0P0WV15 View 3D Structure Click here
A0A0P0WV46 View 3D Structure Click here
A0A0P0WV46 View 3D Structure Click here
A0A0P0WV53 View 3D Structure Click here
A0A0P0WVJ5 View 3D Structure Click here
A0A0P0XXR9 View 3D Structure Click here
A0A0P0XYV3 View 3D Structure Click here
A0A0P0Y0J3 View 3D Structure Click here
A0A0P0Y3R3 View 3D Structure Click here
A0A0R0EHS8 View 3D Structure Click here
A0A0R0EHS9 View 3D Structure Click here
A0A0R0F068 View 3D Structure Click here
A0A0R0F081 View 3D Structure Click here
A0A0R0F0H9 View 3D Structure Click here
A0A0R0FAW1 View 3D Structure Click here
A0A0R0FNT6 View 3D Structure Click here
A0A0R0G7M4 View 3D Structure Click here
A0A0R0G8Q4 View 3D Structure Click here
A0A0R0H2T8 View 3D Structure Click here
A0A0R0HEY5 View 3D Structure Click here
A0A0R0HIB9 View 3D Structure Click here
A0A0R0HQJ3 View 3D Structure Click here
A0A0R0IAH2 View 3D Structure Click here
A0A0R0IHZ4 View 3D Structure Click here
A0A0R0J3J2 View 3D Structure Click here
A0A0R0KK23 View 3D Structure Click here
A0A0R0KPU6 View 3D Structure Click here
A0A0R0KXS9 View 3D Structure Click here
A0A0R0L5V3 View 3D Structure Click here
A0A0R0L5Y3 View 3D Structure Click here
A0A0R0LB73 View 3D Structure Click here
A0A0R0LBD8 View 3D Structure Click here
A0A0R0LFB2 View 3D Structure Click here
A0A0R0LFS9 View 3D Structure Click here
A0A0R0LJ86 View 3D Structure Click here
A0A0R4J4X0 View 3D Structure Click here
A0A1D6DUZ2 View 3D Structure Click here
A0A1D6EBK1 View 3D Structure Click here
A0A1D6EPF6 View 3D Structure Click here
A0A1D6EW19 View 3D Structure Click here
A0A1D6F1V8 View 3D Structure Click here
A0A1D6FNU5 View 3D Structure Click here
A0A1D6FPV6 View 3D Structure Click here
A0A1D6G7J0 View 3D Structure Click here
A0A1D6GYQ2 View 3D Structure Click here
A0A1D6HJ49 View 3D Structure Click here
A0A1D6HJ49 View 3D Structure Click here
A0A1D6HJ50 View 3D Structure Click here
A0A1D6HLS1 View 3D Structure Click here
A0A1D6I3Z4 View 3D Structure Click here
A0A1D6I4Z0 View 3D Structure Click here
A0A1D6ILD0 View 3D Structure Click here
A0A1D6J9Z6 View 3D Structure Click here
A0A1D6JSU2 View 3D Structure Click here
A0A1D6JSU2 View 3D Structure Click here
A0A1D6JZD9 View 3D Structure Click here
A0A1D6KF68 View 3D Structure Click here
A0A1D6L9C7 View 3D Structure Click here
A0A1D6LG87 View 3D Structure Click here
A0A1D6LQG8 View 3D Structure Click here
A0A1D6LRB7 View 3D Structure Click here
A0A1D6LT56 View 3D Structure Click here
A0A1D6LTE4 View 3D Structure Click here
A0A1D6LVZ2 View 3D Structure Click here
A0A1D6LVZ3 View 3D Structure Click here
A0A1D6LVZ4 View 3D Structure Click here
A0A1D6M4N0 View 3D Structure Click here
A0A1D6M6L8 View 3D Structure Click here
A0A1D6MFX0 View 3D Structure Click here
A0A1D6MRZ3 View 3D Structure Click here
A0A1D6NHE5 View 3D Structure Click here
A0A1D6NHF8 View 3D Structure Click here
A0A1D6NQS3 View 3D Structure Click here
A0A1D6NYG9 View 3D Structure Click here
A0A1D6P0U8 View 3D Structure Click here
A0A1D6P250 View 3D Structure Click here
A0A1D6P250 View 3D Structure Click here
A0A1D6PC22 View 3D Structure Click here
A0A1D6PCG1 View 3D Structure Click here
A0A1D6PCS6 View 3D Structure Click here
A0A1D6QDN2 View 3D Structure Click here
A0A1D6QDN2 View 3D Structure Click here
A0A1D6QF24 View 3D Structure Click here
A0A1X7YJF9 View 3D Structure Click here
A0A368UI13 View 3D Structure Click here
A0A368UIJ5 View 3D Structure Click here
A0A368UIJ5 View 3D Structure Click here
B4F996 View 3D Structure Click here
B4FAD6 View 3D Structure Click here
B4FAM7 View 3D Structure Click here
B4FEC9 View 3D Structure Click here
B4FKU2 View 3D Structure Click here
B4FMK8 View 3D Structure Click here
B4FQY2 View 3D Structure Click here
B4FST2 View 3D Structure Click here
B4FVH0 View 3D Structure Click here
B4G268 View 3D Structure Click here
B6SSZ1 View 3D Structure Click here
B6TBI0 View 3D Structure Click here
B9FKP6 View 3D Structure Click here
B9FTL2 View 3D Structure Click here
C0HFF2 View 3D Structure Click here
C0P5R2 View 3D Structure Click here
C0P6K5 View 3D Structure Click here
C0P9X9 View 3D Structure Click here
C0PHD4 View 3D Structure Click here
C0PJ44 View 3D Structure Click here
C6TI78 View 3D Structure Click here
C6TK47 View 3D Structure Click here
C7J7A2 View 3D Structure Click here
F1M6L4 View 3D Structure Click here
F4I037 View 3D Structure Click here
F4IH21 View 3D Structure Click here
F4IWA8 View 3D Structure Click here
F4K5K4 View 3D Structure Click here
F4K5L5 View 3D Structure Click here
F4KHA3 View 3D Structure Click here
I1J5C7 View 3D Structure Click here
I1J5D0 View 3D Structure Click here
I1JBZ5 View 3D Structure Click here
I1JBZ8 View 3D Structure Click here
I1JBZ9 View 3D Structure Click here
I1JC00 View 3D Structure Click here
I1JC01 View 3D Structure Click here
I1JF25 View 3D Structure Click here
I1JI98 View 3D Structure Click here
I1JLC9 View 3D Structure Click here
I1JLD0 View 3D Structure Click here
I1JNM0 View 3D Structure Click here
I1JNT2 View 3D Structure Click here
I1JQS4 View 3D Structure Click here
I1JWA5 View 3D Structure Click here
I1JWA5 View 3D Structure Click here
I1JYX5 View 3D Structure Click here
I1K4Y2 View 3D Structure Click here
I1K507 View 3D Structure Click here
I1K6B0 View 3D Structure Click here
I1KDM6 View 3D Structure Click here
I1KET7 View 3D Structure Click here
I1KHX5 View 3D Structure Click here
I1KL75 View 3D Structure Click here
I1KL92 View 3D Structure Click here
I1KLT0 View 3D Structure Click here
I1KNA1 View 3D Structure Click here
I1KTN7 View 3D Structure Click here
I1KXD0 View 3D Structure Click here
I1KXJ6 View 3D Structure Click here
I1L2D7 View 3D Structure Click here
I1LA06 View 3D Structure Click here
I1LI62 View 3D Structure Click here
I1LLM3 View 3D Structure Click here
I1LMU7 View 3D Structure Click here
I1LV98 View 3D Structure Click here
I1LVJ8 View 3D Structure Click here
I1LWD8 View 3D Structure Click here
I1LWZ4 View 3D Structure Click here
I1LWZ5 View 3D Structure Click here
I1M131 View 3D Structure Click here
I1M1U0 View 3D Structure Click here
I1M2W8 View 3D Structure Click here
I1M6V5 View 3D Structure Click here
I1M7S7 View 3D Structure Click here
I1MBC4 View 3D Structure Click here
I1MER4 View 3D Structure Click here
I1MES0 View 3D Structure Click here
I1MFF3 View 3D Structure Click here
I1MKL4 View 3D Structure Click here
I1MR80 View 3D Structure Click here
I1MSI3 View 3D Structure Click here
I1MZ15 View 3D Structure Click here
I1N0T8 View 3D Structure Click here
I1N1S4 View 3D Structure Click here
I1N317 View 3D Structure Click here
I1N4W1 View 3D Structure Click here
I1N6L8 View 3D Structure Click here
I1N6M2 View 3D Structure Click here
I1N9A1 View 3D Structure Click here
I1N9G3 View 3D Structure Click here
I1N9G4 View 3D Structure Click here
I1NCJ2 View 3D Structure Click here
I1NFC2 View 3D Structure Click here
I1NIC1 View 3D Structure Click here
K7K1G2 View 3D Structure Click here
K7K1K5 View 3D Structure Click here
K7K1K6 View 3D Structure Click here
K7K661 View 3D Structure Click here
K7K662 View 3D Structure Click here
K7K663 View 3D Structure Click here
K7K699 View 3D Structure Click here
K7K912 View 3D Structure Click here
K7KA71 View 3D Structure Click here
K7KCY1 View 3D Structure Click here
K7KF79 View 3D Structure Click here
K7KRY3 View 3D Structure Click here
K7KUN5 View 3D Structure Click here
K7L1Y7 View 3D Structure Click here
K7L4I4 View 3D Structure Click here
K7L4I5 View 3D Structure Click here
K7LD54 View 3D Structure Click here
K7LK30 View 3D Structure Click here
K7LM44 View 3D Structure Click here
K7LQI6 View 3D Structure Click here
K7LWJ0 View 3D Structure Click here
K7LZ22 View 3D Structure Click here
K7M1C7 View 3D Structure Click here
K7MK06 View 3D Structure Click here
K7MPH2 View 3D Structure Click here
K7MQ86 View 3D Structure Click here
K7MS16 View 3D Structure Click here
K7MSD8 View 3D Structure Click here
K7MV65 View 3D Structure Click here
K7MVW5 View 3D Structure Click here
K7MWH4 View 3D Structure Click here
K7MZK9 View 3D Structure Click here
K7N5E5 View 3D Structure Click here
K7TVB0 View 3D Structure Click here
K7U8E2 View 3D Structure Click here
K7UKT1 View 3D Structure Click here
K7ULJ3 View 3D Structure Click here
K7V9G4 View 3D Structure Click here
K7VC90 View 3D Structure Click here
K7VCW9 View 3D Structure Click here
K7W7X5 View 3D Structure Click here
O04523 View 3D Structure Click here
O04621 View 3D Structure Click here
O22960 View 3D Structure Click here
O80872 View 3D Structure Click here
O80919 View 3D Structure Click here
O80940 View 3D Structure Click here
O82509 View 3D Structure Click here
P90793 View 3D Structure Click here
Q0D3C8 View 3D Structure Click here
Q0DDQ9 View 3D Structure Click here
Q0DI08 View 3D Structure Click here
Q0DXX0 View 3D Structure Click here
Q0J225 View 3D Structure Click here
Q0J265 View 3D Structure Click here
Q0WPS0 View 3D Structure Click here
Q10BH4 View 3D Structure Click here
Q10MI5 View 3D Structure Click here
Q10MX2 View 3D Structure Click here
Q10MX4 View 3D Structure Click here
Q10MX5 View 3D Structure Click here
Q1PFD9 View 3D Structure Click here
Q2QXS1 View 3D Structure Click here
Q2QYU2 View 3D Structure Click here
Q2QYW3 View 3D Structure Click here
Q2RBL8 View 3D Structure Click here
Q5BPJ0 View 3D Structure Click here
Q5NA51 View 3D Structure Click here
Q5QNK9 View 3D Structure Click here
Q5VN15 View 3D Structure Click here
Q5VQ32 View 3D Structure Click here
Q5VQ40 View 3D Structure Click here
Q5W6Y3 View 3D Structure Click here
Q5ZDY2 View 3D Structure Click here
Q654T8 View 3D Structure Click here
Q67U25 View 3D Structure Click here
Q67V91 View 3D Structure Click here
Q67V92 View 3D Structure Click here
Q67V93 View 3D Structure Click here
Q67V94 View 3D Structure Click here
Q67VA1 View 3D Structure Click here
Q67XC4 View 3D Structure Click here
Q69RQ8 View 3D Structure Click here
Q6DR10 View 3D Structure Click here
Q6I5B4 View 3D Structure Click here
Q6P1Z5 View 3D Structure Click here
Q6YWS1 View 3D Structure Click here
Q6Z7L5 View 3D Structure Click here
Q6ZGL3 View 3D Structure Click here
Q7X6G0 View 3D Structure Click here
Q84JH9 View 3D Structure Click here
Q84TV3 View 3D Structure Click here
Q84TW8 View 3D Structure Click here
Q84Z39 View 3D Structure Click here
Q84Z44 View 3D Structure Click here
Q8H1R3 View 3D Structure Click here
Q8H2I6 View 3D Structure Click here
Q8H3D7 View 3D Structure Click here
Q8LED3 View 3D Structure Click here
Q8LQG0 View 3D Structure Click here
Q8RV74 View 3D Structure Click here
Q8RXQ1 View 3D Structure Click here
Q8RZF8 View 3D Structure Click here
Q8S237 View 3D Structure Click here
Q8VY22 View 3D Structure Click here
Q8VYR3 View 3D Structure Click here
Q8VYS5 View 3D Structure Click here
Q93ZA5 View 3D Structure Click here
Q940H3 View 3D Structure Click here
Q94K00 View 3D Structure Click here
Q9CAX1 View 3D Structure Click here
Q9FFZ4 View 3D Structure Click here
Q9FG35 View 3D Structure Click here
Q9FGE9 View 3D Structure Click here
Q9FHM0 View 3D Structure Click here
Q9FJ06 View 3D Structure Click here
Q9H1Q7 View 3D Structure Click here
Q9LDG2 View 3D Structure Click here
Q9LFT0 View 3D Structure Click here
Q9LFT1 View 3D Structure Click here
Q9LHL6 View 3D Structure Click here
Q9LRS2 View 3D Structure Click here
Q9LUZ6 View 3D Structure Click here
Q9LY46 View 3D Structure Click here
Q9LZQ1 View 3D Structure Click here
Q9M896 View 3D Structure Click here
Q9SEZ9 View 3D Structure Click here
Q9SIN2 View 3D Structure Click here
Q9SRL3 View 3D Structure Click here
Q9ZQR5 View 3D Structure Click here
Q9ZV89 View 3D Structure Click here