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381  structures 7235  species 0  interactions 28946  sequences 216  architectures

Family: HSP20 (PF00011)

Summary: Hsp20/alpha crystallin family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Hsp20". More...

Hsp20 Edit Wikipedia article

Hsp20/alpha crystallin family
Identifiers
SymbolHSP20
PfamPF00011
InterProIPR002068
PROSITEPDOC00791
SCOPe1shs / SUPFAM
CDDcd06464

The heat shock protein Hsp20 family, also known as small heat shock proteins (sHSPs), is a family of heat shock proteins.

Prokaryotic and eukaryotic organisms respond to heat shock or other environmental stress by inducing the synthesis of proteins collectively known as heat-shock proteins (hsp).[1] Amongst them is a family of proteins with an average molecular weight of 20 kDa, known as the hsp20 proteins.[2] These seem to act as protein chaperones that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates. Structurally, this family is characterised by the presence of a conserved C-terminal domain, alpha-crystallin domain, of about 100 residues. Recently, small heat shock proteins (sHSPs) were found in marine viruses (cyanophages).[3]

Function and regulation

Hsp20, like all heat shock proteins, is in abundance when cells are under stressed conditions.[4] Hsp20 is known to be expressed in many human tissues, including the brain and heart.[5] Hsp20 has been studied extensively in cardiac myocytes and is known to act as a chaperon protein, binding to protein kinase 1 (PDK1) and allowing its nuclear transport.[6] In addition, the phosphorylation of hsp20 has been shown to effect the structure of cells cytoskeletons.[7] Due to hsp20 commonly forming dimers with itself when heated, its function of chaperoning can be greatly affected.[8]

Human small heat shock proteins

References

  1. ^ Lindquist S, Craig EA (1988). "The heat-shock proteins". Annu. Rev. Genet. 22: 631–677. doi:10.1146/annurev.ge.22.120188.003215. PMID 2853609.
  2. ^ Merck KB, de Jong WW, Bloemendal H, Groenen PJ (1994). "Structure and modifications of the junior chaperone alpha-crystallin. From lens transparency to molecular pathology". Eur. J. Biochem. 225 (1): 1–9. doi:10.1111/j.1432-1033.1994.00001.x. PMID 7925426.
  3. ^ Maaroufi H, Tanguay RM (2013). "Analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host". PLoS ONE. 8 (11): e81207. Bibcode:2013PLoSO...881207M. doi:10.1371/journal.pone.0081207. PMC 3827213. PMID 24265841.
  4. ^ LI, D.C.; Lan, Fan; Chen, Dian-Fu; Yang, Wei-Jun; Lu, Bo (2012). "Thermotolerance and molecular chaperone function of the small heat shock protein HSP20 from hyperthermophilic archaeon, Sulfolobus solfataricus P2". Cell Stress Chaperones. 17 (1): 103–8. doi:10.1007/s12192-011-0289-z. PMC 3227843. PMID 21853411.
  5. ^ G.C, Fan; G, Chu; EG, Kranies (May 2005). "Hsp20 and its cardioprotection". Trends Cardiovasc. Med. 15 (4): 138–41. doi:10.1016/j.tcm.2005.05.004. PMID 16099377.
  6. ^ Yan Sin, Yuan; Currie, Susan; P Martin, Lauren; Wills, Tamara; S Baillie, George (2015). "Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy". Cell Commun Signal. 13: 16. doi:10.1186/s12964-015-0094-x. PMC 4356135. PMID 25889640.
  7. ^ M. Dreiza, Catherine; M. Brophy, Colleen; Komalavilas, Padmini; J. Furnish, Elizabeth; Joshi, Lokesh; A. Pallero, Manuel; E. Murphy-Ullrich, Joanne; von Rechenberg, Moritz; J. Ho, Yew-Seng; Richardson, Bonnie; Xu, Nafei; Zhen, Yuejun; M. Peltier, John; Panitch, Alyssa (2005). "Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics". The FASEB Journal. 19 (2): 261–263. doi:10.1096/fj.04-2911fje. PMID 15598710.
  8. ^ van Montfort, RL; Basha, E; Friedrich, KL; Slingsby, C; Vierling, E (2001). "Crystal structure and assembly of a eukaryotic small heat shock protein". Nature Structural Biology. 8 (12): 1025–1030. doi:10.1038/nsb722. PMID 11702068.
This article incorporates text from the public domain Pfam and InterPro: IPR002068

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Hsp20/alpha crystallin family Provide feedback

Not only do small heat-shock-proteins occur in eukaryotes and prokaryotes but they have also now been shown to occur in cyanobacterial phages as well as their bacterial hosts [2].

Literature references

  1. Kim KK, Kim R, Kim SH , Nature 1998;394:595-599.: Crystal structure of a small heat-shock protein. PUBMED:9707123 EPMC:9707123

  2. Maaroufi H, Tanguay RM;, PLoS One. 2013;8:e81207.: Analysis and phylogeny of small heat shock proteins from marine viruses and their cyanobacteria host. PUBMED:24265841 EPMC:24265841


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002068

Prokaryotic and eukaryotic organisms respond to heat shock or other environmental stress by inducing the synthesis of proteins collectively known as heat-shock proteins (hsp) [ PUBMED:2853609 ]. Amongst them is a family of proteins with an average molecular weight of 20 Kd, known as the hsp20 proteins [ PUBMED:7925426 ]. These seem to act as chaperones that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates.

These low-molecular-weight proteins are evolutionarily related to alpha-crystallin [ PUBMED:6285380 ]. Alpha-crystallin is an abundant constituent of the eye lens of most vertebrate species. Its main function appears to be to maintain the correct refractive index and transparency of the lens. It is also found in other tissues where it seems to act as a chaperone [ PUBMED:7925426 , PUBMED:22120592 ]. Other related proteins include certain surface antigens [ PUBMED:1370952 ].

This entry represents a conserved C-terminal domain of about 100 residues characteristic of this group of proteins [ PUBMED:7723051 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan HSP20 (CL0190), which has the following description:

The small heat shock proteins (sHSPs) prevent protein aggregation during heat shock and oppose regulated cell death. A conserved arginine residue in the HSP20/alpha-crystallin domain (Pfam:PF00011) has in fact been implicated in the development of cataracts and myopathies [1]. The CS family (Pfam:PF04969) includes proteins that are known to bind HSP90 [2], as well as p23 (Swiss:Q15185), which is an HSP90 co-chaperone [3].

The clan contains the following 6 members:

ArsA_HSP20 CS GvpH HSP20 PIH1_CS Pih1_fungal_CS

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(25)
Full
(28946)
Representative proteomes UniProt
(89465)
RP15
(5061)
RP35
(14948)
RP55
(27033)
RP75
(40706)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(25)
Full
(28946)
Representative proteomes UniProt
(89465)
RP15
(5061)
RP35
(14948)
RP55
(27033)
RP75
(40706)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(25)
Full
(28946)
Representative proteomes UniProt
(89465)
RP15
(5061)
RP35
(14948)
RP55
(27033)
RP75
(40706)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Sonnhammer ELL
Number in seed: 25
Number in full: 28946
Average length of the domain: 97.20 aa
Average identity of full alignment: 23 %
Average coverage of the sequence by the domain: 53.70 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.8 20.8
Trusted cut-off 20.8 20.8
Noise cut-off 20.7 20.7
Model length: 102
Family (HMM) version: 23
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the HSP20 domain has been found. There are 381 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0N7KIC7 View 3D Structure Click here
A0A0P0V0J3 View 3D Structure Click here
A0A0P0VTB1 View 3D Structure Click here
A0A0R0E8Z6 View 3D Structure Click here
A0A0R0F1R8 View 3D Structure Click here
A0A0R0F3K2 View 3D Structure Click here
A0A0R0GA14 View 3D Structure Click here
A0A0R0GPZ3 View 3D Structure Click here
A0A0R0GZI4 View 3D Structure Click here
A0A0R0H093 View 3D Structure Click here
A0A0R0HSQ5 View 3D Structure Click here
A0A0R0I012 View 3D Structure Click here
A0A0R0IBV5 View 3D Structure Click here
A0A0R0II89 View 3D Structure Click here
A0A0R0IYL6 View 3D Structure Click here
A0A0R0J5K1 View 3D Structure Click here
A0A0R0J9F3 View 3D Structure Click here
A0A0R0K9D7 View 3D Structure Click here
A0A0R0KI86 View 3D Structure Click here
A0A0R0L186 View 3D Structure Click here
A0A0R0LBQ9 View 3D Structure Click here
A0A0R4IC54 View 3D Structure Click here
A0A0R4IG31 View 3D Structure Click here
A0A0R4J3J4 View 3D Structure Click here
A0A0R4J3N3 View 3D Structure Click here
A0A0R4J3Q7 View 3D Structure Click here
A0A0R4J3Q9 View 3D Structure Click here
A0A0R4J3X4 View 3D Structure Click here
A0A0R4J4X6 View 3D Structure Click here
A0A0R4J5L7 View 3D Structure Click here
A0A140G945 View 3D Structure Click here
A0A140LGF7 View 3D Structure Click here
A0A1D6EGH3 View 3D Structure Click here
A0A1D6F559 View 3D Structure Click here
A0A1D6GL72 View 3D Structure Click here
A0A1D6GL74 View 3D Structure Click here
A0A1D6HI24 View 3D Structure Click here
A0A1D6I3X6 View 3D Structure Click here
A0A1D6JXF4 View 3D Structure Click here
A0A1D6KBW7 View 3D Structure Click here
A0A1D6KC46 View 3D Structure Click here
A0A1D6KUQ3 View 3D Structure Click here
A0A1D6KZ63 View 3D Structure Click here
A0A1D6LR68 View 3D Structure Click here
A0A1D6LZI5 View 3D Structure Click here
A0A1D6ME89 View 3D Structure Click here
A0A1D6MZJ2 View 3D Structure Click here
A0A1D6N718 View 3D Structure Click here
A0A1D6NKW6 View 3D Structure Click here
A0A1I6CMC9 View 3D Structure Click here
A2BHS1 View 3D Structure Click here
A4I4V9 View 3D Structure Click here
A4VAK4 View 3D Structure Click here
A5JV83 View 3D Structure Click here
A5PMM3 View 3D Structure Click here
B0M0L8 View 3D Structure Click here
B0M1A7 View 3D Structure Click here
B4F976 View 3D Structure Click here
B4F9E8 View 3D Structure Click here
B4F9K4 View 3D Structure Click here
B4FDS8 View 3D Structure Click here
B4FES7 View 3D Structure Click here
B4FT59 View 3D Structure Click here
B4G197 View 3D Structure Click here
B6SIX0 View 3D Structure Click here
B6SLV6 View 3D Structure Click here
B6SRC0 View 3D Structure Click here
B6SRT5 View 3D Structure Click here
B6TDB5 View 3D Structure Click here
B6TMR8 View 3D Structure Click here
B6TR54 View 3D Structure Click here
B6U6V5 View 3D Structure Click here
B6UD04 View 3D Structure Click here
B7EZJ7 View 3D Structure Click here
C0P8J4 View 3D Structure Click here
C0PD31 View 3D Structure Click here
C0PJF1 View 3D Structure Click here
C0PPG1 View 3D Structure Click here
C4J5C1 View 3D Structure Click here
C4J643 View 3D Structure Click here
C6SWI2 View 3D Structure Click here
C6SXG1 View 3D Structure Click here
C6T1V2 View 3D Structure Click here
C6T2F2 View 3D Structure Click here
C6T2N6 View 3D Structure Click here
C6T5U3 View 3D Structure Click here
C6TC68 View 3D Structure Click here
C6THQ1 View 3D Structure Click here
C6TNH7 View 3D Structure Click here
C7G080 View 3D Structure Click here
C7IY02 View 3D Structure Click here
C7IZC4 View 3D Structure Click here
D4ACX7 View 3D Structure Click here
F1Q807 View 3D Structure Click here
F1QZY5 View 3D Structure Click here
F1R2H6 View 3D Structure Click here
F4HWW7 View 3D Structure Click here
F4K6X6 View 3D Structure Click here
G3XCP0 View 3D Structure Click here
G5EE36 View 3D Structure Click here
G5EE65 View 3D Structure Click here
G5EF99 View 3D Structure Click here
I1J732 View 3D Structure Click here
I1JJ64 View 3D Structure Click here
I1JSQ5 View 3D Structure Click here
I1JU00 View 3D Structure Click here
I1JW03 View 3D Structure Click here
I1JYK1 View 3D Structure Click here
I1JZS1 View 3D Structure Click here
I1K8F1 View 3D Structure Click here
I1KAZ9 View 3D Structure Click here
I1L3W2 View 3D Structure Click here
I1LC12 View 3D Structure Click here
I1LDG1 View 3D Structure Click here
I1LID7 View 3D Structure Click here
I1LJW6 View 3D Structure Click here
I1LNC8 View 3D Structure Click here
I1LUS1 View 3D Structure Click here
I1M3H4 View 3D Structure Click here
I1M6V1 View 3D Structure Click here
I1M7E1 View 3D Structure Click here
I1M965 View 3D Structure Click here
I1MFG5 View 3D Structure Click here
I1MGW7 View 3D Structure Click here
I1MK54 View 3D Structure Click here
I1MKZ4 View 3D Structure Click here
I1MTQ5 View 3D Structure Click here
I1ND86 View 3D Structure Click here
K7KB29 View 3D Structure Click here
K7KDM2 View 3D Structure Click here
K7KP15 View 3D Structure Click here
K7KVW6 View 3D Structure Click here
K7KYJ0 View 3D Structure Click here
K7L2S4 View 3D Structure Click here
K7L8A0 View 3D Structure Click here
K7LEW2 View 3D Structure Click here
K7LXB2 View 3D Structure Click here
K7ME23 View 3D Structure Click here
K7MGP7 View 3D Structure Click here
K7MHL6 View 3D Structure Click here
K7MNE0 View 3D Structure Click here
K7MQU7 View 3D Structure Click here
K7MXW1 View 3D Structure Click here
K7N3X1 View 3D Structure Click here
K7TTJ0 View 3D Structure Click here
K7UST5 View 3D Structure Click here
K7V336 View 3D Structure Click here
K7VA55 View 3D Structure Click here
K7VQ98 View 3D Structure Click here
M9PCC9 View 3D Structure Click here
O14368 View 3D Structure Click here
O14558 View 3D Structure Click here
O35878 View 3D Structure Click here
O49710 View 3D Structure Click here
O53673 View 3D Structure Click here
O64960 View 3D Structure Click here
O74984 View 3D Structure Click here
O81822 View 3D Structure Click here
P02489 View 3D Structure Click here
P02511 View 3D Structure Click here
P02513 View 3D Structure Click here
P02515 View 3D Structure Click here
P02516 View 3D Structure Click here
P02517 View 3D Structure Click here
P02518 View 3D Structure Click here
P02519 View 3D Structure Click here
P02520 View 3D Structure Click here
P04792 View 3D Structure Click here
P04793 View 3D Structure Click here
P04794 View 3D Structure Click here
P04795 View 3D Structure Click here
P05477 View 3D Structure Click here
P05478 View 3D Structure Click here
P05812 View 3D Structure Click here
P06581 View 3D Structure Click here
P06582 View 3D Structure Click here
P09887 View 3D Structure Click here
P0C054 View 3D Structure Click here
P0C058 View 3D Structure Click here
P13853 View 3D Structure Click here
P14602 View 3D Structure Click here
P15992 View 3D Structure Click here
P19036 View 3D Structure Click here
P19037 View 3D Structure Click here
P21769 View 3D Structure Click here
P22979 View 3D Structure Click here
P23927 View 3D Structure Click here
P23928 View 3D Structure Click here
P24622 View 3D Structure Click here
P24623 View 3D Structure Click here
P24631 View 3D Structure Click here
P24632 View 3D Structure Click here
P27777 View 3D Structure Click here
P29830 View 3D Structure Click here
P30236 View 3D Structure Click here
P31170 View 3D Structure Click here
P31673 View 3D Structure Click here
P34328 View 3D Structure Click here
P34696 View 3D Structure Click here
P35385 View 3D Structure Click here
P42930 View 3D Structure Click here
P82147 View 3D Structure Click here
P97541 View 3D Structure Click here
P9WMK1 View 3D Structure Click here
Q08275 View 3D Structure Click here
Q0DY72 View 3D Structure Click here
Q0E4A8 View 3D Structure Click here
Q109M7 View 3D Structure Click here
Q10P60 View 3D Structure Click here
Q12329 View 3D Structure Click here
Q12988 View 3D Structure Click here
Q14990 View 3D Structure Click here
Q16082 View 3D Structure Click here
Q17849 View 3D Structure Click here
Q19227 View 3D Structure Click here
Q19228 View 3D Structure Click here
Q1ZXL6 View 3D Structure Click here
Q20164 View 3D Structure Click here
Q20363 View 3D Structure Click here
Q20660 View 3D Structure Click here
Q208N7 View 3D Structure Click here
Q2FVN2 View 3D Structure Click here
Q38806 View 3D Structure Click here
Q39818 View 3D Structure Click here
Q39819 View 3D Structure Click here
Q41815 View 3D Structure Click here
Q4E663 View 3D Structure Click here
Q53M11 View 3D Structure Click here
Q54I91 View 3D Structure Click here
Q54LU4 View 3D Structure Click here
Q54VP4 View 3D Structure Click here
Q54W43 View 3D Structure Click here
Q54WT6 View 3D Structure Click here
Q550E9 View 3D Structure Click here
Q551F8 View 3D Structure Click here
Q551G1 View 3D Structure Click here
Q552K9 View 3D Structure Click here
Q552K9 View 3D Structure Click here
Q55GH8 View 3D Structure Click here
Q566R8 View 3D Structure Click here
Q57733 View 3D Structure Click here
Q5AHH4 View 3D Structure Click here
Q5EBG6 View 3D Structure Click here
Q5VRY1 View 3D Structure Click here
Q61999 View 3D Structure Click here
Q652V8 View 3D Structure Click here
Q67X83 View 3D Structure Click here
Q69XV5 View 3D Structure Click here
Q6AUW3 View 3D Structure Click here
Q6EQG6 View 3D Structure Click here
Q6K7E9 View 3D Structure Click here
Q6L4S2 View 3D Structure Click here
Q6Z6L5 View 3D Structure Click here
Q6Z7V2 View 3D Structure Click here
Q6ZFT8 View 3D Structure Click here
Q76NU5 View 3D Structure Click here
Q7EZ57 View 3D Structure Click here
Q7G566 View 3D Structure Click here
Q7G754 View 3D Structure Click here
Q7XE46 View 3D Structure Click here
Q7XUW5 View 3D Structure Click here
Q84J50 View 3D Structure Click here
Q84K79 View 3D Structure Click here
Q84Q72 View 3D Structure Click here
Q84Q77 View 3D Structure Click here
Q86H60 View 3D Structure Click here
Q86I25 View 3D Structure Click here
Q86KF5 View 3D Structure Click here
Q86KF5 View 3D Structure Click here
Q8I5T9 View 3D Structure Click here
Q8IB02 View 3D Structure Click here
Q8IES0 View 3D Structure Click here
Q8IQW5 View 3D Structure Click here
Q8MMN1 View 3D Structure Click here
Q8MPA5 View 3D Structure Click here
Q8MPA7 View 3D Structure Click here
Q8S1F2 View 3D Structure Click here
Q8UUZ6 View 3D Structure Click here
Q940Y3 View 3D Structure Click here
Q943E6 View 3D Structure Click here
Q943E7 View 3D Structure Click here
Q943E9 View 3D Structure Click here
Q943Q3 View 3D Structure Click here
Q96331 View 3D Structure Click here
Q99PR8 View 3D Structure Click here
Q9BQS6 View 3D Structure Click here
Q9DAM3 View 3D Structure Click here
Q9EPX0 View 3D Structure Click here
Q9FGM9 View 3D Structure Click here
Q9FHQ3 View 3D Structure Click here
Q9FIT9 View 3D Structure Click here
Q9JK92 View 3D Structure Click here
Q9LNW0 View 3D Structure Click here
Q9M670 View 3D Structure Click here
Q9PUR2 View 3D Structure Click here
Q9QUK5 View 3D Structure Click here
Q9QZ57 View 3D Structure Click here
Q9QZ58 View 3D Structure Click here
Q9S732 View 3D Structure Click here
Q9SRD6 View 3D Structure Click here
Q9SSQ8 View 3D Structure Click here
Q9SYG1 View 3D Structure Click here
Q9UBY9 View 3D Structure Click here
Q9UJY1 View 3D Structure Click here
Q9VL41 View 3D Structure Click here
Q9VSA9 View 3D Structure Click here
Q9VSX2 View 3D Structure Click here
Q9XET1 View 3D Structure Click here
Q9XIE3 View 3D Structure Click here
Q9ZVC6 View 3D Structure Click here
Q9ZW31 View 3D Structure Click here