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319  structures 468  species 0  interactions 19493  sequences 1247  architectures

Family: Kunitz_BPTI (PF00014)

Summary: Kunitz/Bovine pancreatic trypsin inhibitor domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Kunitz domain". More...

Kunitz domain Edit Wikipedia article

Kunitz/Bovine pancreatic trypsin inhibitor domain
PDB 1kth EBI.jpg
3D structure of the C-terminal Kunitz domain from human collagen alpha-3(VI) chain.[1]
Identifiers
SymbolKunitz_BPTI
PfamPF00014
InterProIPR002223
PROSITEPDOC00252
SCOPe5pti / SUPFAM
CDDcd00109

Kunitz domains are the active domains of proteins that inhibit the function of protein degrading enzymes or, more specifically, domains of Kunitz-type are protease inhibitors. They are relatively small with a length of about 50 to 60 amino acids and a molecular weight of 6 kDa. Examples of Kunitz-type protease inhibitors are aprotinin (bovine pancreatic trypsin inhibitor, BPTI), Alzheimer's amyloid precursor protein (APP), and tissue factor pathway inhibitor (TFPI).

Standalone Kunitz domains are used as a framework for the development of new pharmaceutical drugs.[2]

Structure

The structure is a disulfide rich alpha+beta fold. Bovine pancreatic trypsin inhibitor is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP, P17726). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways.[3] TAP molecules are highly dipolar,[4] and are arranged to form a twisted two-stranded antiparallel beta sheet followed by an alpha helix.[3]

The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family[5] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus, a species of poxvirus. They are short (about 50 to 60 amino acid residues) alpha/beta proteins with few secondary structures. The fold is constrained by three disulfide bonds. The type example for this family is BPTI[6] (or basic protease inhibitor), but the family includes numerous other members,[7][8][9][10] such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rat mast cell inhibitor of trypsin; a domain found in an alternatively spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha-1 and alpha-3 chains of type VI and type VII collagens; tissue factor pathway inhibitor precursor; and Kunitz STI protease inhibitor contained in legume seeds.

Drug development

Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. These properties have led to attempts at developing biopharmaceutical drugs from Kunitz domains. Candidate domains are selected from molecular libraries containing over 10 million variants with the aid of display techniques like phage display,[11] and can be produced in large scale by genetically engineered organisms.

The first of these drugs to be marketed was the kallikrein inhibitor ecallantide, used for the treatment of hereditary angioedema.[11] It was approved in the United States in 2009.[12] Another example is depelestat, an inhibitor of neutrophil elastase that has undergone Phase II clinical trials for the treatment of acute respiratory distress syndrome in 2006/2007[13] and has also been described as a potential inhalable cystic fibrosis treatment.[14]

Examples

Human proteins containing this domain include:

Several plant protease inhibitors of the Kunitz family, the Kunitz-STI protein family, include a beta trefoil fold.[15]

References

  1. ^ PDB: 1KTH​; Arnoux B, Ducruix A, Prangé T (July 2002). "Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution (0.9 Ã…)". Acta Crystallogr. D. 58 (Pt 7): 1252–4. doi:10.1107/S0907444902007333. PMID 12077460.
  2. ^ Nixon, AE; Wood, CR (2006). "Engineered protein inhibitors of proteases". Current Opinion in Drug Discovery & Development. 9 (2): 261–8. PMID 16566296.
  3. ^ a b Antuch W, Güntert P, Billeter M, Hawthorne T, Grossenbacher H, Wüthrich K (September 1994). "NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata". FEBS Lett. 352 (2): 251–7. doi:10.1016/0014-5793(94)00941-4. PMID 7925983.
  4. ^ St Charles R, Padmanabhan K, Arni RV, Padmanabhan KP, Tulinsky A (February 2000). "Structure of tick anticoagulant peptide at 1.6 A resolution complexed with bovine pancreatic trypsin inhibitor". Protein Sci. 9 (2): 265–72. doi:10.1110/ps.9.2.265. PMC 2144540. PMID 10716178.
  5. ^ Rawlings ND, Barrett AJ, Tolle DP (2004). "Evolutionary families of peptidase inhibitors". Biochem. J. 378 (Pt 3): 705–16. doi:10.1042/BJ20031825. PMC 1224039. PMID 14705960.
  6. ^ Wlodawer A, Housset D, Kim KS, Fuchs J, Woodward C (1991). "Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor". J. Mol. Biol. 220 (3): 757–770. doi:10.1016/0022-2836(91)90115-M. PMID 1714504.
  7. ^ Salier JP (1990). "Inter-alpha-trypsin inhibitor: emergence of a family within the Kunitz-type protease inhibitor superfamily". Trends Biochem. Sci. 15 (11): 435–439. doi:10.1016/0968-0004(90)90282-G. PMID 1703675.
  8. ^ Takahashi K, Ikeo K, Gojobori T (1992). "Evolutionary origin of a Kunitz-type trypsin inhibitor domain inserted in the amyloid beta precursor protein of Alzheimer's disease". J. Mol. Evol. 34 (6): 536–543. doi:10.1007/BF00160466. PMID 1593645.
  9. ^ Sprecher CA, Foster DC, Kisiel W, Mathewes S (1994). "Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3353–3357. Bibcode:1994PNAS...91.3353S. doi:10.1073/pnas.91.8.3353. PMC 43575. PMID 8159751.
  10. ^ Biemann K, Papayannopoulos IA (1992). "Amino acid sequence of a protease inhibitor isolated from Sarcophaga bullata determined by mass spectrometry". Protein Sci. 1 (2): 278–288. doi:10.1002/pro.5560010210. PMC 2142190. PMID 1304909.
  11. ^ a b Lehmann, A (2008). "Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery". Expert Opinion on Biological Therapy. 8 (8): 1187–99. doi:10.1517/14712598.8.8.1187. PMID 18613770.
  12. ^ Dyax Corp. (2009). "Full prescibing information Kalbitor" (PDF). Retrieved 2010-05-02.
  13. ^ Clinical trial number NCT00455767 for "Safety and Efficacy Study of Depelestat in Acute Respiratory Distress Syndrome (ARDS) Patients" at ClinicalTrials.gov
  14. ^ Attucci, S; Gauthier, A; Korkmaz, B; Delépine, P; Martino, MF; Saudubray, F; Diot, P; Gauthier, F (2006). "EPI-hNE4, a proteolysis-resistant inhibitor of human neutrophil elastase and potential anti-inflammatory drug for treating cystic fibrosis". The Journal of Pharmacology and Experimental Therapeutics. 318 (2): 803–9. doi:10.1124/jpet.106.103440. PMID 16627747.
  15. ^ Azarkan M, Martinez-Rodriguez S, Buts L, Baeyens-Volant D, Garcia-Pino A (Dec 2011). "The plasticity of the β-trefoil fold constitutes an evolutionary platform for protease inhibition". The Journal of Biological Chemistry. 286 (51): 43726–34. doi:10.1074/jbc.M111.291310. PMC 3243510. PMID 22027836.
This article incorporates text from the public domain Pfam and InterPro: IPR002223

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Kunitz/Bovine pancreatic trypsin inhibitor domain Provide feedback

Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP, P17726). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways [1]. TAP molecules are highly dipolar [2] and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix [1].

Literature references

  1. Antuch W, Guntert P, Billeter M, Hawthorne T, Grossenbacher H, Wuthrich K; , FEBS Lett 1994;352:251-257.: NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata. PUBMED:7925983 EPMC:7925983

  2. St Charles R, Padmanabhan K, Arni RV, Padmanabhan KP, Tulinsky A; , Protein Sci 2000;9:265-272.: Structure of tick anticoagulant peptide at 1.6 A resolution complexed with bovine pancreatic trypsin inhibitor. PUBMED:10716178 EPMC:10716178


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002223

The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [ PUBMED:14705960 ] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. They are short (~50 residue) alpha/beta proteins with few secondary structures. The fold is constrained by 3 disulphide bonds. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) [ PUBMED:1714504 ] (or basic protease inhibitor), but the family includes numerous other members [ PUBMED:1703675 , PUBMED:1593645 , PUBMED:8159751 , PUBMED:1304909 ], such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rodent mast cell inhibitor of trypsin; a domain found in an alternatively-spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha(1) and alpha(3) chains of type VII and type VI collagens; and tissue factor pathway inhibitor precursor.

The pancreatic trypsin inhibitor (Kunitz) family [ PUBMED:6996568 , PUBMED:1703675 , PUBMED:1593645 ] is one of the numerous families of serine proteinase inhibitors. The basic structure of such a type of inhibitor is shown in the following schematic representation:

            +-----------------------+
            |  +--------+           |
            |  |      **|*******    |
          xxCxxC#xxxCxxxCxxxxxxCxxxxCxx
                    |          |
                    +----------+

            {------50 residues------}

'C': conserved cysteine involved in a disulfide bond.
'#': active site residue.
'*': position of the pattern.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(99)
Full
(19493)
Representative proteomes UniProt
(39468)
RP15
(6370)
RP35
(10077)
RP55
(17585)
RP75
(22004)
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HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(99)
Full
(19493)
Representative proteomes UniProt
(39468)
RP15
(6370)
RP35
(10077)
RP55
(17585)
RP75
(22004)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(99)
Full
(19493)
Representative proteomes UniProt
(39468)
RP15
(6370)
RP35
(10077)
RP55
(17585)
RP75
(22004)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Fenech M
Number in seed: 99
Number in full: 19493
Average length of the domain: 53.10 aa
Average identity of full alignment: 36 %
Average coverage of the sequence by the domain: 15.34 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.0 21.0
Trusted cut-off 21.1 21.0
Noise cut-off 20.9 20.9
Model length: 53
Family (HMM) version: 25
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Kunitz_BPTI domain has been found. There are 319 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4JDE7 View 3D Structure Click here
A0A0G2K680 View 3D Structure Click here
A0A0G2KCR2 View 3D Structure Click here
A0A0G2L8G8 View 3D Structure Click here
A0A0R4IN41 View 3D Structure Click here
A0A2R8PW45 View 3D Structure Click here
A0A2R8PW45 View 3D Structure Click here
A0A2R8Q4V0 View 3D Structure Click here
A0A2R8QCE4 View 3D Structure Click here
A0A2R8QCE4 View 3D Structure Click here
A0A2R8QKV2 View 3D Structure Click here
A0A2R8RP31 View 3D Structure Click here
A0A2R8RP31 View 3D Structure Click here
A0A5E4LX17 View 3D Structure Click here
A1Z7L2 View 3D Structure Click here
A5JYT7 View 3D Structure Click here
B0S6C1 View 3D Structure Click here
B0S6C1 View 3D Structure Click here
B0S6C1 View 3D Structure Click here
B0V0E5 View 3D Structure Click here
B4ZJ91 View 3D Structure Click here
B9EQU3 View 3D Structure Click here
C0H5W1 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C0Z3L5 View 3D Structure Click here
C4NAN9 View 3D Structure Click here
C9QNZ6 View 3D Structure Click here
D3Z9K5 View 3D Structure Click here
D3Z9K5 View 3D Structure Click here
D3ZD40 View 3D Structure Click here
D3ZN64 View 3D Structure Click here
D4A0Q5 View 3D Structure Click here
D4A2Z2 View 3D Structure Click here
E1JHS1 View 3D Structure Click here
E1JHS4 View 3D Structure Click here
E1JHS5 View 3D Structure Click here
E1JI09 View 3D Structure Click here
E1JJ70 View 3D Structure Click here
E7EYN3 View 3D Structure Click here
E7EYN3 View 3D Structure Click here
E7F0N3 View 3D Structure Click here
E7F0N3 View 3D Structure Click here
E7FAB1 View 3D Structure Click here
E7FAB1 View 3D Structure Click here
E7FCX1 View 3D Structure Click here
E7FCX1 View 3D Structure Click here
E9PTI0 View 3D Structure Click here
F1LVU2 View 3D Structure Click here
F1LW49 View 3D Structure Click here
F1QAB3 View 3D Structure Click here
F1QEV7 View 3D Structure Click here
F1QEV7 View 3D Structure Click here
F1QEV7 View 3D Structure Click here
F1QRA8 View 3D Structure Click here
F1QXZ6 View 3D Structure Click here
F1QXZ6 View 3D Structure Click here
F6ULY1 View 3D Structure Click here
F8Y417 View 3D Structure Click here
F8Y417 View 3D Structure Click here
G3V7D5 View 3D Structure Click here
G3V7D5 View 3D Structure Click here
G3V7D5 View 3D Structure Click here
G3V8S0 View 3D Structure Click here
G3V8S0 View 3D Structure Click here
G5EBJ3 View 3D Structure Click here
G5EBJ3 View 3D Structure Click here
G5ED57 View 3D Structure Click here
G5ED57 View 3D Structure Click here
I2HAB0 View 3D Structure Click here
J3KMK8 View 3D Structure Click here
M9MRN8 View 3D Structure Click here
M9MS11 View 3D Structure Click here
M9NDD9 View 3D Structure Click here
M9PCH1 View 3D Structure Click here
M9PE65 View 3D Structure Click here
O16701 View 3D Structure Click here
O16784 View 3D Structure Click here
O16784 View 3D Structure Click here
O17644 View 3D Structure Click here
O17644 View 3D Structure Click here
O17644 View 3D Structure Click here
O17644 View 3D Structure Click here
O17644 View 3D Structure Click here
O17644 View 3D Structure Click here
O17644 View 3D Structure Click here
O17644 View 3D Structure Click here
O35536 View 3D Structure Click here
O35536 View 3D Structure Click here
O35536 View 3D Structure Click here
O43278 View 3D Structure Click here
O43278 View 3D Structure Click here
O43291 View 3D Structure Click here
O43291 View 3D Structure Click here
O44621 View 3D Structure Click here
O44622 View 3D Structure Click here
O54819 View 3D Structure Click here
O54819 View 3D Structure Click here
O54819 View 3D Structure Click here
O62247 View 3D Structure Click here
O62504 View 3D Structure Click here
O62504 View 3D Structure Click here
O62504 View 3D Structure Click here
O62504 View 3D Structure Click here
O62504 View 3D Structure Click here
O76840 View 3D Structure Click here
O76840 View 3D Structure Click here
O76840 View 3D Structure Click here
O76840 View 3D Structure Click here
O76840 View 3D Structure Click here
O76840 View 3D Structure Click here
O76840 View 3D Structure Click here
O76840 View 3D Structure Click here
O76840 View 3D Structure Click here
O76840 View 3D Structure Click here
O76840 View 3D Structure Click here
O95428 View 3D Structure Click here
O95925 View 3D Structure Click here
P02760 View 3D Structure Click here
P02760 View 3D Structure Click here
P05067 View 3D Structure Click here
P08592 View 3D Structure Click here
P0C5J5 View 3D Structure Click here
P0C5J5 View 3D Structure Click here
P10646 View 3D Structure Click here
P10646 View 3D Structure Click here
P10646 View 3D Structure Click here
P12023 View 3D Structure Click here
P15943 View 3D Structure Click here
P48307 View 3D Structure Click here
P48307 View 3D Structure Click here
P48307 View 3D Structure Click here
P49223 View 3D Structure Click here
Q02445 View 3D Structure Click here
Q02445 View 3D Structure Click here
Q02445 View 3D Structure Click here
Q03610 View 3D Structure Click here
Q03610 View 3D Structure Click here
Q03610 View 3D Structure Click here
Q03610 View 3D Structure Click here
Q03610 View 3D Structure Click here
Q06481 View 3D Structure Click here
Q07456 View 3D Structure Click here
Q07456 View 3D Structure Click here
Q09983 View 3D Structure Click here
Q09983 View 3D Structure Click here
Q09983 View 3D Structure Click here
Q09983 View 3D Structure Click here
Q09983 View 3D Structure Click here
Q11101 View 3D Structure Click here
Q17457 View 3D Structure Click here
Q18761 View 3D Structure Click here
Q18761 View 3D Structure Click here
Q18761 View 3D Structure Click here
Q18761 View 3D Structure Click here
Q18761 View 3D Structure Click here
Q19021 View 3D Structure Click here
Q19021 View 3D Structure Click here
Q19021 View 3D Structure Click here
Q19305 View 3D Structure Click here
Q1LYP0 View 3D Structure Click here
Q1WCN6 View 3D Structure Click here
Q1WCN6 View 3D Structure Click here
Q1WCN6 View 3D Structure Click here
Q20008 View 3D Structure Click here
Q20008 View 3D Structure Click here
Q20014 View 3D Structure Click here
Q20014 View 3D Structure Click here
Q21418 View 3D Structure Click here
Q21418 View 3D Structure Click here
Q21418 View 3D Structure Click here
Q21418 View 3D Structure Click here
Q21418 View 3D Structure Click here
Q22685 View 3D Structure Click here
Q22685 View 3D Structure Click here
Q22685 View 3D Structure Click here
Q22685 View 3D Structure Click here
Q22685 View 3D Structure Click here
Q23456 View 3D Structure Click here
Q23456 View 3D Structure Click here
Q23456 View 3D Structure Click here
Q23456 View 3D Structure Click here
Q23456 View 3D Structure Click here
Q23456 View 3D Structure Click here
Q23456 View 3D Structure Click here
Q2UY09 View 3D Structure Click here
Q2UY11 View 3D Structure Click here
Q3UW09 View 3D Structure Click here
Q3UW55 View 3D Structure Click here
Q3V5K6 View 3D Structure Click here
Q3ZAL6 View 3D Structure Click here
Q4KUS1 View 3D Structure Click here
Q4R127 View 3D Structure Click here
Q4V4A5 View 3D Structure Click here
Q4V608 View 3D Structure Click here
Q4V621 View 3D Structure Click here
Q4V8Q2 View 3D Structure Click here
Q4V8Q2 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q5ZR42 View 3D Structure Click here
Q64240 View 3D Structure Click here
Q64240 View 3D Structure Click here
Q6IE19 View 3D Structure Click here
Q6IL46 View 3D Structure Click here
Q6NUX0 View 3D Structure Click here
Q6NUX0 View 3D Structure Click here
Q6UDR6 View 3D Structure Click here
Q7JKQ3 View 3D Structure Click here
Q7K3Y9 View 3D Structure Click here
Q7KN04 View 3D Structure Click here
Q7TQN3 View 3D Structure Click here
Q7TQN3 View 3D Structure Click here
Q8IPF1 View 3D Structure Click here
Q8IQ06 View 3D Structure Click here
Q8IUA0 View 3D Structure Click here
Q8R0S6 View 3D Structure Click here
Q8R0S6 View 3D Structure Click here
Q8SZI8 View 3D Structure Click here
Q8TEU8 View 3D Structure Click here
Q8TEU8 View 3D Structure Click here
Q94163 View 3D Structure Click here
Q94164 View 3D Structure Click here
Q95X61 View 3D Structure Click here
Q96NZ8 View 3D Structure Click here
Q96NZ8 View 3D Structure Click here
Q9D263 View 3D Structure Click here
Q9DA01 View 3D Structure Click here
Q9EPX2 View 3D Structure Click here
Q9R097 View 3D Structure Click here
Q9R097 View 3D Structure Click here
Q9U350 View 3D Structure Click here
Q9U350 View 3D Structure Click here
Q9U350 View 3D Structure Click here
Q9U350 View 3D Structure Click here
Q9U350 View 3D Structure Click here
Q9U350 View 3D Structure Click here
Q9UAZ2 View 3D Structure Click here
Q9VCM3 View 3D Structure Click here
Q9VCM5 View 3D Structure Click here
Q9VE31 View 3D Structure Click here
Q9VF11 View 3D Structure Click here
Q9VQT1 View 3D Structure Click here
Q9VQT5 View 3D Structure Click here
Q9VQT6 View 3D Structure Click here
Q9VQT7 View 3D Structure Click here
Q9VQT8 View 3D Structure Click here
Q9VQT9 View 3D Structure Click here
Q9VQU0 View 3D Structure Click here
Q9WU03 View 3D Structure Click here
Q9WU03 View 3D Structure Click here
U4PMC3 View 3D Structure Click here
U4PMC3 View 3D Structure Click here
U4PMC3 View 3D Structure Click here
U4PMC3 View 3D Structure Click here
U4PMC3 View 3D Structure Click here