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39  structures 5695  species 0  interactions 119688  sequences 1148  architectures

Family: Sugar_tr (PF00083)

Summary: Sugar (and other) transporter

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Sugar (and other) transporter Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR005828

This entry represents a subfamily of the major facilitator superfamily. Members in this family include sugar transporters, which are responsible for the binding and transport of various carbohydrates, organic alcohols, and acids in a wide range of prokaryotic and eukaryotic organisms [ PUBMED:3839598 ]. Most but not all members of this family catalyse sugar transport [ PUBMED:26098515 ].

Recent genome-sequencing data and a wealth of biochemical and molecular genetic investigations have revealed the occurrence of dozens of families of primary and secondary transporters. Two such families have been found to occur ubiquitously in all classifications of living organisms. These are the ATP-binding cassette (ABC) superfamily and the major facilitator superfamily (MFS), also called the uniporter-symporter-antiporter family. While ABC family permeases are in general multicomponent primary active transporters, capable of transporting both small molecules and macromolecules in response to ATP hydrolysis the MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. Although well over 100 families of transporters have now been recognised and classified, the ABC superfamily and MFS account for nearly half of the solute transporters encoded within the genomes of microorganisms. They are also prevalent in higher organisms. The importance of these two families of transport systems to living organisms can therefore not be overestimated [ PUBMED:9529885 ].

The MFS was originally believed to function primarily in the uptake of sugars but subsequent studies revealed that drug efflux systems, Krebs cycle metabolites, organophosphate:phosphate exchangers, oligosaccharide:H1 symport permeases, and bacterial aromatic acid permeases were all members of the MFS. These observations led to the probability that the MFS is far more widespread in nature and far more diverse in function than had been thought previously. 17 subgroups of the MFS have been identified [ PUBMED:9529885 ].

Evidence suggests that the MFS permeases arose by a tandem intragenic duplication event in the early prokaryotes. This event generated a 2-transmembrane-spanner (TMS) protein topology from a primordial 6-TMS unit. Surprisingly, all currently recognised MFS permeases retain the two six-TMS units within a single polypeptide chain, although in 3 of the 17 MFS families, an additional two TMSs are found [ PUBMED:8987357 ]. Moreover, the well-conserved MFS specific motif between TMS2 and TMS3 and the related but less well conserved motif between TMS8 and TMS9 [ PUBMED:1970645 ] prove to be a characteristic of virtually all of the more than 300 MFS proteins identified.

This family includes sugar and other type of transporters.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan MFS (CL0015), which has the following description:

The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth [1]. It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity [1]. All permeases of the MFS possess either 12 or 14 transmembrane helices [1].

The clan contains the following 23 members:

Acatn ATG22 BT1 Folate_carrier FPN1 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_4 MFS_5 MFS_Mycoplasma Nodulin-like Nuc_H_symport Nucleoside_tran OATP PTR2 PUCC Sugar_tr TLC TRI12 UNC-93

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(33)
Full
(119688)
Representative proteomes UniProt
(288468)
RP15
(15752)
RP35
(48805)
RP55
(94162)
RP75
(150594)
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HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(33)
Full
(119688)
Representative proteomes UniProt
(288468)
RP15
(15752)
RP35
(48805)
RP55
(94162)
RP75
(150594)
Alignment:
Format:
Order:
Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(33)
Full
(119688)
Representative proteomes UniProt
(288468)
RP15
(15752)
RP35
(48805)
RP55
(94162)
RP75
(150594)
Raw Stockholm Download     Download   Download        
Gzipped Download     Download   Download        

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite hmmls-iteration
Previous IDs: sugar_tr;
Type: Family
Sequence Ontology: SO:0100021
Author: Sonnhammer ELL
Number in seed: 33
Number in full: 119688
Average length of the domain: 359.40 aa
Average identity of full alignment: 17 %
Average coverage of the sequence by the domain: 79.60 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.3 22.3
Trusted cut-off 22.3 22.3
Noise cut-off 22.2 22.2
Model length: 452
Family (HMM) version: 26
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Sugar_tr domain has been found. There are 39 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096PY37 View 3D Structure Click here
A0A096PY37 View 3D Structure Click here
A0A0B4KFK6 View 3D Structure Click here
A0A0B4KGW3 View 3D Structure Click here
A0A0B4KGW3 View 3D Structure Click here
A0A0B4KHM5 View 3D Structure Click here
A0A0K3AVV4 View 3D Structure Click here
A0A0N7KJ56 View 3D Structure Click here
A0A0N7KMW2 View 3D Structure Click here
A0A0P0V7Z4 View 3D Structure Click here
A0A0P0VDA3 View 3D Structure Click here
A0A0P0VKQ4 View 3D Structure Click here
A0A0P0VRT7 View 3D Structure Click here
A0A0P0VRT7 View 3D Structure Click here
A0A0P0VSK4 View 3D Structure Click here
A0A0P0W4Z9 View 3D Structure Click here
A0A0P0WAY2 View 3D Structure Click here
A0A0P0WAY2 View 3D Structure Click here
A0A0P0WB92 View 3D Structure Click here
A0A0P0WCA4 View 3D Structure Click here
A0A0P0WFB6 View 3D Structure Click here
A0A0P0WFS2 View 3D Structure Click here
A0A0P0WGH5 View 3D Structure Click here
A0A0P0WGJ2 View 3D Structure Click here
A0A0P0WIF1 View 3D Structure Click here
A0A0P0WM58 View 3D Structure Click here
A0A0P0X7B4 View 3D Structure Click here
A0A0P0X7V4 View 3D Structure Click here
A0A0P0X814 View 3D Structure Click here
A0A0P0XKW0 View 3D Structure Click here
A0A0P0XML3 View 3D Structure Click here
A0A0P0Y4M3 View 3D Structure Click here
A0A0P0Y4S0 View 3D Structure Click here
A0A0R0EAF3 View 3D Structure Click here
A0A0R0ESS5 View 3D Structure Click here
A0A0R0ETB5 View 3D Structure Click here
A0A0R0F0H4 View 3D Structure Click here
A0A0R0F0H4 View 3D Structure Click here
A0A0R0F7N4 View 3D Structure Click here
A0A0R0FEL0 View 3D Structure Click here
A0A0R0FHK7 View 3D Structure Click here
A0A0R0FSD4 View 3D Structure Click here
A0A0R0FYN5 View 3D Structure Click here
A0A0R0FZ54 View 3D Structure Click here
A0A0R0FZ59 View 3D Structure Click here
A0A0R0FZD6 View 3D Structure Click here
A0A0R0G388 View 3D Structure Click here
A0A0R0G388 View 3D Structure Click here
A0A0R0G755 View 3D Structure Click here
A0A0R0G755 View 3D Structure Click here
A0A0R0G755 View 3D Structure Click here
A0A0R0G809 View 3D Structure Click here
A0A0R0GHH4 View 3D Structure Click here
A0A0R0GUC5 View 3D Structure Click here
A0A0R0H1C7 View 3D Structure Click here
A0A0R0HGC8 View 3D Structure Click here
A0A0R0HGC8 View 3D Structure Click here
A0A0R0HGC8 View 3D Structure Click here
A0A0R0I7U7 View 3D Structure Click here
A0A0R0IJL2 View 3D Structure Click here
A0A0R0J1S7 View 3D Structure Click here
A0A0R0J555 View 3D Structure Click here
A0A0R0J8A9 View 3D Structure Click here
A0A0R0J8A9 View 3D Structure Click here
A0A0R0JIL1 View 3D Structure Click here
A0A0R0JIL1 View 3D Structure Click here
A0A0R0JT45 View 3D Structure Click here
A0A0R0JT45 View 3D Structure Click here
A0A0R0K1S3 View 3D Structure Click here
A0A0R0K1S3 View 3D Structure Click here
A0A0R0KNA6 View 3D Structure Click here
A0A0R0KUT0 View 3D Structure Click here
A0A0R0KVA7 View 3D Structure Click here
A0A0R0LF34 View 3D Structure Click here
A0A0R4IIC8 View 3D Structure Click here
A0A0R4IKJ8 View 3D Structure Click here
A0A0R4IMT8 View 3D Structure Click here
A0A0R4J3V5 View 3D Structure Click here
A0A0R4J3X7 View 3D Structure Click here
A0A0R4J4D4 View 3D Structure Click here
A0A1D6DT49 View 3D Structure Click here
A0A1D6DT50 View 3D Structure Click here
A0A1D6E9C2 View 3D Structure Click here
A0A1D6E9C5 View 3D Structure Click here
A0A1D6E9C5 View 3D Structure Click here
A0A1D6E9C8 View 3D Structure Click here
A0A1D6EES3 View 3D Structure Click here
A0A1D6EES5 View 3D Structure Click here
A0A1D6EES6 View 3D Structure Click here
A0A1D6EP34 View 3D Structure Click here
A0A1D6EVD0 View 3D Structure Click here
A0A1D6EZM7 View 3D Structure Click here
A0A1D6EZN4 View 3D Structure Click here
A0A1D6F305 View 3D Structure Click here
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A0A1D6FCA5 View 3D Structure Click here
A0A1D6FDY2 View 3D Structure Click here
A0A1D6FKK2 View 3D Structure Click here
A0A1D6FKM5 View 3D Structure Click here
A0A1D6FKM5 View 3D Structure Click here
A0A1D6FKN0 View 3D Structure Click here
A0A1D6FWR3 View 3D Structure Click here
A0A1D6GE24 View 3D Structure Click here
A0A1D6GPN6 View 3D Structure Click here
A0A1D6GQ24 View 3D Structure Click here
A0A1D6GQ24 View 3D Structure Click here
A0A1D6GQ53 View 3D Structure Click here
A0A1D6GTC9 View 3D Structure Click here
A0A1D6H4J3 View 3D Structure Click here
A0A1D6HB78 View 3D Structure Click here
A0A1D6HSI3 View 3D Structure Click here
A0A1D6HSI3 View 3D Structure Click here
A0A1D6HVS2 View 3D Structure Click here
A0A1D6HXP9 View 3D Structure Click here
A0A1D6HYA1 View 3D Structure Click here
A0A1D6HYA1 View 3D Structure Click here
A0A1D6I1X6 View 3D Structure Click here
A0A1D6I3U3 View 3D Structure Click here
A0A1D6I3U3 View 3D Structure Click here
A0A1D6IFG4 View 3D Structure Click here
A0A1D6IHX5 View 3D Structure Click here
A0A1D6IHX8 View 3D Structure Click here
A0A1D6IHY2 View 3D Structure Click here
A0A1D6IHY3 View 3D Structure Click here
A0A1D6J484 View 3D Structure Click here
A0A1D6J7U0 View 3D Structure Click here
A0A1D6J968 View 3D Structure Click here
A0A1D6JAA1 View 3D Structure Click here
A0A1D6JAA1 View 3D Structure Click here
A0A1D6JF71 View 3D Structure Click here
A0A1D6JSE6 View 3D Structure Click here
A0A1D6JTD3 View 3D Structure Click here
A0A1D6K2C4 View 3D Structure Click here
A0A1D6K3V9 View 3D Structure Click here
A0A1D6K3W1 View 3D Structure Click here
A0A1D6K6F3 View 3D Structure Click here
A0A1D6KCI4 View 3D Structure Click here
A0A1D6KJL4 View 3D Structure Click here
A0A1D6KLZ4 View 3D Structure Click here
A0A1D6KXA5 View 3D Structure Click here
A0A1D6KXA5 View 3D Structure Click here
A0A1D6KXC2 View 3D Structure Click here
A0A1D6KXC2 View 3D Structure Click here
A0A1D6L677 View 3D Structure Click here
A0A1D6LG74 View 3D Structure Click here
A0A1D6LL27 View 3D Structure Click here
A0A1D6MD62 View 3D Structure Click here
A0A1D6MD70 View 3D Structure Click here
A0A1D6MD70 View 3D Structure Click here
A0A1D6MM01 View 3D Structure Click here
A0A1D6MPE6 View 3D Structure Click here
A0A1D6MR72 View 3D Structure Click here
A0A1D6N1F5 View 3D Structure Click here
A0A1D6NJW4 View 3D Structure Click here
A0A1D6NLF8 View 3D Structure Click here
A0A1D6NZS4 View 3D Structure Click here
A0A1D6P7W4 View 3D Structure Click here
A0A1D6P8G0 View 3D Structure Click here
A0A1D6PIC3 View 3D Structure Click here
A0A1D6PPY8 View 3D Structure Click here
A0A1D6PQ92 View 3D Structure Click here
A0A1D6PQ92 View 3D Structure Click here
A0A1D6Q3M7 View 3D Structure Click here
A0A1D6Q5H6 View 3D Structure Click here
A0A1D6QNY8 View 3D Structure Click here
A0A1D6QSS3 View 3D Structure Click here
A0A1D8PCL1 View 3D Structure Click here
A0A1D8PG81 View 3D Structure Click here
A0A1D8PG82 View 3D Structure Click here
A0A1D8PH98 View 3D Structure Click here
A0A1D8PKH9 View 3D Structure Click here
A0A1D8PL74 View 3D Structure Click here
A0A1D8PLY7 View 3D Structure Click here
A0A1D8PN12 View 3D Structure Click here
A0A1D8PN12 View 3D Structure Click here
A0A1D8PN14 View 3D Structure Click here
A0A1D8PN14 View 3D Structure Click here
A0A1D8PQI9 View 3D Structure Click here
A0A1D8PQJ5 View 3D Structure Click here
A0A1D8PQL0 View 3D Structure Click here
A0A1D8PSC9 View 3D Structure Click here
A0A1D8PSH1 View 3D Structure Click here
A0A1D8PSX6 View 3D Structure Click here
A0A1D8PTF7 View 3D Structure Click here
A0A1D8PTJ9 View 3D Structure Click here
A0A1Q1CLX2 View 3D Structure Click here
A0A1X7YG26 View 3D Structure Click here
A0A1Z1CGZ4 View 3D Structure Click here
A0A238UKL7 View 3D Structure Click here
A0A286Y8I9 View 3D Structure Click here
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A0A2R8QA97 View 3D Structure Click here
A0A2R8QF01 View 3D Structure Click here
A0A2R8QL75 View 3D Structure Click here
A0A2R8QL75 View 3D Structure Click here
A0A2R8QL95 View 3D Structure Click here
A0A2R8QL95 View 3D Structure Click here
A0A368UIG5 View 3D Structure Click here
A0A368UNF5 View 3D Structure Click here
A0A381N054 View 3D Structure Click here
A0A381N054 View 3D Structure Click here
A1A5C7 View 3D Structure Click here
A1Z8N1 View 3D Structure Click here
A1ZA52 View 3D Structure Click here
A2CEX0 View 3D Structure Click here
A2CF25 View 3D Structure Click here
A2RVG5 View 3D Structure Click here
A4HWI5 View 3D Structure Click here
A4I0Q6 View 3D Structure Click here
A4I8N6 View 3D Structure Click here
A4IC83 View 3D Structure Click here
A4IC83 View 3D Structure Click here
A4IG77 View 3D Structure Click here
A4ZYQ5 View 3D Structure Click here
A6NK97 View 3D Structure Click here
A6NKX4 View 3D Structure Click here
A8JQU1 View 3D Structure Click here
A9JTH0 View 3D Structure Click here
A9ULS7 View 3D Structure Click here
B0UY92 View 3D Structure Click here
B2GV36 View 3D Structure Click here
B2RT89 View 3D Structure Click here
B4FDN6 View 3D Structure Click here
B4FF54 View 3D Structure Click here
B4FQN6 View 3D Structure Click here
B4FR74 View 3D Structure Click here
B4FS29 View 3D Structure Click here
B4FSQ6 View 3D Structure Click here
B4FWK6 View 3D Structure Click here
B4FYT1 View 3D Structure Click here
B4FZ36 View 3D Structure Click here
B4G157 View 3D Structure Click here
B6TAG3 View 3D Structure Click here
B6TI70 View 3D Structure Click here
B6TXX9 View 3D Structure Click here
B6U6U2 View 3D Structure Click here
B6U6U2 View 3D Structure Click here
B7F8I2 View 3D Structure Click here
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B8A122 View 3D Structure Click here
B8JJ01 View 3D Structure Click here
C0HE66 View 3D Structure Click here
C0LZ80 View 3D Structure Click here
C0P3C7 View 3D Structure Click here
C0P495 View 3D Structure Click here
C0P753 View 3D Structure Click here
C0PE06 View 3D Structure Click here
C0PE06 View 3D Structure Click here
C0PHL2 View 3D Structure Click here
C3UZD0 View 3D Structure Click here
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C3UZD6 View 3D Structure Click here
C3UZD7 View 3D Structure Click here
C4JC09 View 3D Structure Click here
C6TMP6 View 3D Structure Click here
C7J066 View 3D Structure Click here
C7J4X0 View 3D Structure Click here
D3Z8A7 View 3D Structure Click here
D3ZCM6 View 3D Structure Click here
D3ZLC4 View 3D Structure Click here
D3ZNG4 View 3D Structure Click here
D3ZNG4 View 3D Structure Click here
D3ZVY8 View 3D Structure Click here
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D3ZXZ4 View 3D Structure Click here
D4A237 View 3D Structure Click here
D4A271 View 3D Structure Click here
E7F6Z2 View 3D Structure Click here
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E7FF19 View 3D Structure Click here
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E9AHY8 View 3D Structure Click here
E9AHY8 View 3D Structure Click here
E9PU08 View 3D Structure Click here
E9QDT2 View 3D Structure Click here
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E9QGX4 View 3D Structure Click here
F1Q880 View 3D Structure Click here
F1Q9K9 View 3D Structure Click here
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F1QII7 View 3D Structure Click here
F1QKX0 View 3D Structure Click here
F1QN13 View 3D Structure Click here
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F1QZA8 View 3D Structure Click here
F1QZR1 View 3D Structure Click here
F1R0H0 View 3D Structure Click here
F1R0H0 View 3D Structure Click here
F1R0Q1 View 3D Structure Click here
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F1RB41 View 3D Structure Click here
F4JJ77 View 3D Structure Click here
F4JJ78 View 3D Structure Click here
G3V9H5 View 3D Structure Click here
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G5EC34 View 3D Structure Click here
G5EC93 View 3D Structure Click here
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G5EDU0 View 3D Structure Click here
G5EEI9 View 3D Structure Click here
G5EGL6 View 3D Structure Click here
H9C1D0 View 3D Structure Click here
I1J669 View 3D Structure Click here
I1J807 View 3D Structure Click here
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I1JCP6 View 3D Structure Click here
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I1JVE9 View 3D Structure Click here
I1JVF0 View 3D Structure Click here
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I1JWX1 View 3D Structure Click here
I1K3G6 View 3D Structure Click here
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I1K5X7 View 3D Structure Click here
I1K6U5 View 3D Structure Click here
I1K6U5 View 3D Structure Click here
I1K9Z3 View 3D Structure Click here
I1KCR2 View 3D Structure Click here
I1KF36 View 3D Structure Click here
I1KFQ4 View 3D Structure Click here
I1KG17 View 3D Structure Click here
I1KGN0 View 3D Structure Click here
I1KQQ8 View 3D Structure Click here
I1KRW0 View 3D Structure Click here
I1KRW0 View 3D Structure Click here
I1KRW1 View 3D Structure Click here
I1KRW1 View 3D Structure Click here
I1KV64 View 3D Structure Click here
I1KVW4 View 3D Structure Click here
I1KVW4 View 3D Structure Click here
I1L248 View 3D Structure Click here
I1L248 View 3D Structure Click here
I1L3X2 View 3D Structure Click here
I1L4I4 View 3D Structure Click here
I1L4M1 View 3D Structure Click here
I1L798 View 3D Structure Click here
I1L7A2 View 3D Structure Click here
I1L7H9 View 3D Structure Click here
I1LE59 View 3D Structure Click here
I1LF83 View 3D Structure Click here
I1LFJ6 View 3D Structure Click here
I1LFT2 View 3D Structure Click here
I1LG72 View 3D Structure Click here
I1LHP8 View 3D Structure Click here
I1LHP9 View 3D Structure Click here
I1LHQ0 View 3D Structure Click here
I1LHQ1 View 3D Structure Click here
I1LHQ2 View 3D Structure Click here
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