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2106  structures 8488  species 0  interactions 28965  sequences 353  architectures

Family: Tubulin (PF00091)

Summary: Tubulin/FtsZ family, GTPase domain

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Tubulin/FtsZ family, GTPase domain Provide feedback

This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.

Literature references

  1. Nogales E, Wolf SG, Downing KH; , Nature 1998;391:199-203.: Structure of the alphabeta tubulin dimer by electron crystallography. PUBMED:9428769 EPMC:9428769

  2. Nogales E, Downing KH, Amos LA, Lowe J; , Nat Struct Biol 1998;5:451-458.: Tubulin and FtsZ form a distinct family of GTPases. PUBMED:9628483 EPMC:9628483

  3. Lowe J, Amos LA; , Nature 1998;391:203-206.: Crystal structure of the bacterial cell-division protein FtsZ [see comments] PUBMED:9428770 EPMC:9428770

  4. Miklos GL, Yamamoto M, Burns RG, Maleszka R; , Proc Natl Acad Sci U S A. 1997;94:5189-5194.: An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs. PUBMED:9144213 EPMC:9144213

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR003008

This entry represents a GTPase domain found in all tubulin chains, such as tubulin alpha, beta and gamma chains, and some bacterial FtsZ proteins [ PUBMED:9628483 ]. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells [ PUBMED:9144213 , PUBMED:9428770 ]. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings invitro and isubiquitous in bacteria and archaea.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Tubulin (CL0566), which has the following description:

The characteristic families of this clan are the tubulin GTPase domain and the alpha and beta tubulin subunits. A segmental duplication early on in the primate lineage has led to the creation of up to three tubulin-like domains in the higher primates. The most N-terminal one is the Misato domain, which probably represents the original domain [3].

The clan contains the following 4 members:

Misat_Tub_SegII Tubulin Tubulin_2 Tubulin_3


We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

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Representative proteomes UniProt

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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: tubulin;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A , Sonnhammer ELL , Griffiths-Jones SR
Number in seed: 87
Number in full: 28965
Average length of the domain: 177.00 aa
Average identity of full alignment: 35 %
Average coverage of the sequence by the domain: 42.75 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 33.0 33.0
Trusted cut-off 33.0 33.0
Noise cut-off 32.9 32.9
Model length: 197
Family (HMM) version: 27
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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The tree shows the occurrence of this domain across different species. More...


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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Tubulin domain has been found. There are 2106 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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