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343  structures 6103  species 0  interactions 51876  sequences 2813  architectures

Family: VWA (PF00092)

Summary: von Willebrand factor type A domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Von Willebrand factor type A domain". More...

Von Willebrand factor type A domain Edit Wikipedia article

von Willebrand factor type A domain
PDB 1lfa EBI.jpg
Structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.[1]
Identifiers
SymbolVWA
PfamPF00092
Pfam clanCL0128
InterProIPR002035
SCOPe1lfa / SUPFAM
CDDcd00198

The von Willebrand factor type A (vWA) domain is a protein domain named after its occurrence in von Willebrand factor (vWF), a large multimeric glycoprotein found in blood plasma. Mutant forms of vWF are involved in the aetiology of bleeding disorders.[2] This type A domain is the prototype for a protein superfamily (InterProIPR036465; see also Pfam clan).

The vWA domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins.[3][4][5] Although the majority of vWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWA domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands.[3] A number of human diseases arise from mutations in vWA domains.

Secondary structure prediction from 75 aligned vWA sequences has revealed a largely alternating sequence of alpha-helices and beta-strands.[4] Fold recognition algorithms were used to score sequence compatibility with a library of known structures: the vWA domain fold was predicted to be a doubly wound, open, twisted beta-sheet flanked by alpha-helices.[6] 3D structures have been determined for the I-domains of integrins CD11b (with bound magnesium)[7] and CD11a (with bound manganese).[8] The domain adopts a classic alpha/beta Rossmann fold and contains an unusual metal ion coordination site at its surface. It has been suggested that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands.[7] The residues constituting the MIDAS motif in the CD11b and CD11a I-domains are completely conserved, but the manner in which the metal ion is coordinated differs slightly.[8]

Human proteins containing this domain

ANTXR1; ANTXR2; BF; C2; CACHD1; CACNA2D1; CACNA2D2; CACNA2D3; CACNA2D4; CFB; CLCA1; CLCA2; CLCA4; COCH; COL12A1; COL14A1; COL20A1; COL21A1; COL22A1; COL28; COL6A1; COL6A2; COL6A3; COL7A1; COLA1L; CaCC1; ITGA1; ITGA10; ITGA11; ITGA2; ITGAD; ITGAE; ITGAL; ITGAM; ITGAX; ITIH1; ITIH2; ITIH3; ITIH4; ITIH5; ITIH5L; LOC285929; LOC340267; LOC389462; LOH11CR2A; MATN1; MATN2; MATN3; MATN4; PARP4; SEL-OB; SVEP1; VIT; VWA1; VWA2; VWF; hCLCA1; hCLCA2; CMG2;

References

  1. ^ Qu A, Leahy DJ (October 1995). "Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10277–81. doi:10.1073/pnas.92.22.10277. PMC 40779. PMID 7479767.
  2. ^ Ruggeri ZM, Ware J (1993). "von Willebrand factor". FASEB J. 7 (2): 308–316. PMID 8440408.
  3. ^ a b Colombatti A, Bonaldo P, Doliana R (1993). "Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins". Matrix. 13 (4): 297–306. doi:10.1016/S0934-8832(11)80025-9. PMID 8412987.
  4. ^ a b Smith KF, Haris PI, Chapman D, Perkins SJ, Williams SC, Sim RB (1994). "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform infrared spectroscopy. Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. Mol. Biol. 238 (1): 104–119. doi:10.1006/jmbi.1994.1271. PMID 8145250.
  5. ^ Bork P (1991). "Shuffled domains in extracellular proteins". FEBS Lett. 286 (1): 47–54. doi:10.1016/0014-5793(91)80937-X. PMID 1864378.
  6. ^ Perkins SJ, Edwards YJ (1995). "The protein fold of the von Willebrand factor type A domain is predicted to be similar to the open twisted beta-sheet flanked by alpha-helices found in human ras-p21". FEBS Lett. 358 (3): 283–286. doi:10.1016/0014-5793(94)01447-9. PMID 7843416.
  7. ^ a b Lee JO, Rieu P, Arnaout MA, Liddington R (1995). "Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)". Cell. 80 (4): 631–638. doi:10.1016/0092-8674(95)90517-0. PMID 7867070.
  8. ^ a b Leahy DJ, Qu A (1995). "Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10277–10281. doi:10.1073/pnas.92.22.10277. PMC 40779. PMID 7479767.

External links

This article incorporates text from the public domain Pfam and InterPro: IPR002035

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

von Willebrand factor type A domain Provide feedback

No Pfam abstract.

Literature references

  1. Bork P, Rohde K; , Biochem J 1991;279:908-911.: More von Willebrand factor type A domains? Sequence similarities with malaria thrombospondin-related anonymous protein, dihydropyridine-sensitive calcium channel and inter-alpha-trypsin inhibitor. PUBMED:1659389 EPMC:1659389


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002035

The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. Mutant forms are involved in the aetiology of bleeding disorders [ PUBMED:8440408 ]. In von Willebrand factor, the type A domain (vWF) is the prototype for a protein superfamily. The vWF domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins [ PUBMED:8412987 , PUBMED:8145250 , PUBMED:1864378 ]. Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands [ PUBMED:8412987 ]. A number of human diseases arise from mutations in VWA domains.

Secondary structure prediction from 75 aligned vWF sequences has revealed a largely alternating sequence of alpha-helices and beta-strands [ PUBMED:8145250 ]. The vWF domain fold is predicted to be a doubly-wound, open, twisted beta-sheet flanked by alpha-helices [ PUBMED:7843416 ]. 3D structures have been determined for the I-domains of integrins alpha-M (CD11b; with bound magnesium) [ PUBMED:7867070 ] and alpha-L (CD11a; with bound manganese) [ PUBMED:7479767 ]. The domain adopts a classic alpha/beta Rossmann fold and contains an unusual metal ion coordination site at its surface. It has been suggested that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands [ PUBMED:7867070 ]. The residues constituting the MIDAS motif in the CD11b and CD11a I-domains are completely conserved, but the manner in which the metal ion is coordinated differs slightly [ PUBMED:7479767 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan vWA-like (CL0128), which has the following description:

To add.

The clan contains the following 19 members:

CobT_C Copine DUF1194 DUF2201 DUF444 DUF58 Integrin_beta ivWA Ku_N Med25_VWA Sec23_trunk Ssl1 Ste5_C Tfb4 VWA vWA-TerF-like VWA_2 VWA_3 VWA_CoxE

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(127)
Full
(51876)
Representative proteomes UniProt
(130462)
RP15
(8236)
RP35
(21548)
RP55
(47546)
RP75
(66844)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(127)
Full
(51876)
Representative proteomes UniProt
(130462)
RP15
(8236)
RP35
(21548)
RP55
(47546)
RP75
(66844)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(127)
Full
(51876)
Representative proteomes UniProt
(130462)
RP15
(8236)
RP35
(21548)
RP55
(47546)
RP75
(66844)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prodom
Previous IDs: vwa;
Type: Domain
Sequence Ontology: SO:0000417
Author: Sonnhammer ELL , Bateman A
Number in seed: 127
Number in full: 51876
Average length of the domain: 171.50 aa
Average identity of full alignment: 18 %
Average coverage of the sequence by the domain: 29.74 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.8 23.8
Trusted cut-off 23.8 23.8
Noise cut-off 23.7 23.7
Model length: 175
Family (HMM) version: 30
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the VWA domain has been found. There are 343 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JTX7 View 3D Structure Click here
A0A0G2JTX7 View 3D Structure Click here
A0A0G2JTX7 View 3D Structure Click here
A0A0G2JTX7 View 3D Structure Click here
A0A0G2JTX7 View 3D Structure Click here
A0A0G2JTX7 View 3D Structure Click here
A0A0G2JTX7 View 3D Structure Click here
A0A0G2JTX7 View 3D Structure Click here
A0A0G2JTX7 View 3D Structure Click here
A0A0G2JYF9 View 3D Structure Click here
A0A0G2K470 View 3D Structure Click here
A0A0G2K7L7 View 3D Structure Click here
A0A0G2KCR2 View 3D Structure Click here
A0A0G2KCR2 View 3D Structure Click here
A0A0G2L8G8 View 3D Structure Click here
A0A0G2L8G8 View 3D Structure Click here
A0A0N7KTY9 View 3D Structure Click here
A0A0P0V5S3 View 3D Structure Click here
A0A0P0XB69 View 3D Structure Click here
A0A0P0XV48 View 3D Structure Click here
A0A0P0XVD7 View 3D Structure Click here
A0A0P0XVD7 View 3D Structure Click here
A0A0P0Y7Y6 View 3D Structure Click here
A0A0R4IB74 View 3D Structure Click here
A0A0R4ICZ6 View 3D Structure Click here
A0A0R4IGD8 View 3D Structure Click here
A0A0R4IJT2 View 3D Structure Click here
A0A0R4IP59 View 3D Structure Click here
A0A0R4IR54 View 3D Structure Click here
A0A0R4IT72 View 3D Structure Click here
A0A0R4ITJ5 View 3D Structure Click here
A0A0R4ITJ5 View 3D Structure Click here
A0A0R4IU44 View 3D Structure Click here
A0A131MBU3 View 3D Structure Click here
A0A164D3B2 View 3D Structure Click here
A0A164D3B2 View 3D Structure Click here
A0A1D5NSP7 View 3D Structure Click here
A0A1D6F4K8 View 3D Structure Click here
A0A1D6GPU3 View 3D Structure Click here
A0A1D6HD96 View 3D Structure Click here
A0A1D6HNV0 View 3D Structure Click here
A0A1D6JNC8 View 3D Structure Click here
A0A1D6JNC9 View 3D Structure Click here
A0A1D6KTS9 View 3D Structure Click here
A0A1D6KTT0 View 3D Structure Click here
A0A1I9LN98 View 3D Structure Click here
A0A1X7RBP4 View 3D Structure Click here
A0A2I3BPJ2 View 3D Structure Click here
A0A2R8QDT8 View 3D Structure Click here
A0A2R8QKR9 View 3D Structure Click here
A0A2R8QKS0 View 3D Structure Click here
A0A2R8QMM2 View 3D Structure Click here
A0A2R8QMM2 View 3D Structure Click here
A0A2R8QMM2 View 3D Structure Click here
A0A2R8RP31 View 3D Structure Click here
A0A2R8RP31 View 3D Structure Click here
A0A2R8RP31 View 3D Structure Click here
A0A2R8RP31 View 3D Structure Click here
A0A2R8RP31 View 3D Structure Click here
A0A2R8RQ80 View 3D Structure Click here
A0A2R8RSK7 View 3D Structure Click here
A0A368UHZ2 View 3D Structure Click here
A2AR69 View 3D Structure Click here
A2AX52 View 3D Structure Click here
A2AX52 View 3D Structure Click here
A2AX52 View 3D Structure Click here
A2AX52 View 3D Structure Click here
A2AX52 View 3D Structure Click here
A2AX52 View 3D Structure Click here
A2AX52 View 3D Structure Click here
A5WWJ4 View 3D Structure Click here
A5WWJ4 View 3D Structure Click here
A6H584 View 3D Structure Click here
A6H584 View 3D Structure Click here
A6H584 View 3D Structure Click here
A6H584 View 3D Structure Click here
A6H584 View 3D Structure Click here
A6H584 View 3D Structure Click here
A6H584 View 3D Structure Click here
A6H584 View 3D Structure Click here
A6H584 View 3D Structure Click here
A6NF34 View 3D Structure Click here
A6NMZ7 View 3D Structure Click here
A6NMZ7 View 3D Structure Click here
A6NMZ7 View 3D Structure Click here
A6NMZ7 View 3D Structure Click here
A6NMZ7 View 3D Structure Click here
A6NMZ7 View 3D Structure Click here
A6NMZ7 View 3D Structure Click here
A6NMZ7 View 3D Structure Click here
A6X935 View 3D Structure Click here
A8TX70 View 3D Structure Click here
A8TX70 View 3D Structure Click here
A8TX70 View 3D Structure Click here
A8TX70 View 3D Structure Click here
A8TX70 View 3D Structure Click here
A8TX70 View 3D Structure Click here
A8TX70 View 3D Structure Click here
A8TX70 View 3D Structure Click here
A8TX70 View 3D Structure Click here
B1H259 View 3D Structure Click here
B1H259 View 3D Structure Click here
B2RYM3 View 3D Structure Click here
B3DFV8 View 3D Structure Click here
B3DFV8 View 3D Structure Click here
C0H5W1 View 3D Structure Click here
C0H5W1 View 3D Structure Click here
C0HF51 View 3D Structure Click here
C0P695 View 3D Structure Click here
C4J5Y0 View 3D Structure Click here
D3ZE04 View 3D Structure Click here
D3ZE04 View 3D Structure Click here
D3ZFH5 View 3D Structure Click here
D3ZII5 View 3D Structure Click here
D3ZL10 View 3D Structure Click here
D3ZL10 View 3D Structure Click here
D3ZL10 View 3D Structure Click here
D3ZL10 View 3D Structure Click here
D3ZL10 View 3D Structure Click here
D3ZL10 View 3D Structure Click here
D3ZL10 View 3D Structure Click here
D3ZL10 View 3D Structure Click here
D3ZMS3 View 3D Structure Click here
D3ZMS3 View 3D Structure Click here
D3ZN64 View 3D Structure Click here
D3ZN64 View 3D Structure Click here
D3ZUL3 View 3D Structure Click here
D3ZUL3 View 3D Structure Click here
D3ZUL3 View 3D Structure Click here
D3ZW82 View 3D Structure Click here
D3ZWZ1 View 3D Structure Click here
D3ZZT9 View 3D Structure Click here
D3ZZT9 View 3D Structure Click here
D4A0J4 View 3D Structure Click here
D4A0J4 View 3D Structure Click here
D4A0J4 View 3D Structure Click here
E7F2W8 View 3D Structure Click here
E7F463 View 3D Structure Click here
E7F9M9 View 3D Structure Click here
E7FB76 View 3D Structure Click here
E7FCH6 View 3D Structure Click here
E7FCV8 View 3D Structure Click here
E7FCV8 View 3D Structure Click here
E7FCV8 View 3D Structure Click here
E7FD47 View 3D Structure Click here
E7FF10 View 3D Structure Click here
E9PUL3 View 3D Structure Click here
E9Q6R1 View 3D Structure Click here
E9Q7P1 View 3D Structure Click here
E9QDD7 View 3D Structure Click here
E9QDN6 View 3D Structure Click here
E9QDN6 View 3D Structure Click here
E9QGV2 View 3D Structure Click here
E9QHI5 View 3D Structure Click here
F1LNH3 View 3D Structure Click here
F1LNH3 View 3D Structure Click here
F1LNH3 View 3D Structure Click here
F1LP44 View 3D Structure Click here
F1LT78 View 3D Structure Click here
F1LUU1 View 3D Structure Click here
F1LXS3 View 3D Structure Click here
F1LXS3 View 3D Structure Click here
F1M095 View 3D Structure Click here
F1M095 View 3D Structure Click here
F1M6H4 View 3D Structure Click here
F1M6H4 View 3D Structure Click here
F1M6H4 View 3D Structure Click here
F1M6H4 View 3D Structure Click here
F1M6H4 View 3D Structure Click here
F1M6H4 View 3D Structure Click here
F1M6H4 View 3D Structure Click here
F1M7N4 View 3D Structure Click here
F1Q4S4 View 3D Structure Click here
F1Q4S4 View 3D Structure Click here
F1Q5U3 View 3D Structure Click here
F1Q6P3 View 3D Structure Click here
F1Q6P3 View 3D Structure Click here
F1Q6P3 View 3D Structure Click here
F1Q6X1 View 3D Structure Click here
F1QAB3 View 3D Structure Click here
F1QAB3 View 3D Structure Click here
F1QC06 View 3D Structure Click here
F1QH95 View 3D Structure Click here
F1QJB3 View 3D Structure Click here
F1QSJ9 View 3D Structure Click here
F1QTF9 View 3D Structure Click here
F1QWI2 View 3D Structure Click here
F1R7M3 View 3D Structure Click here
F1R886 View 3D Structure Click here
F1R9Y1 View 3D Structure Click here
F1R9Y1 View 3D Structure Click here
F1REM9 View 3D Structure Click here
F4IU12 View 3D Structure Click here
F4JSV3 View 3D Structure Click here
G3V9L9 View 3D Structure Click here
G5ECR0 View 3D Structure Click here
G5EE24 View 3D Structure Click here
G5EGU7 View 3D Structure Click here
I1J4W4 View 3D Structure Click here
I1J6W3 View 3D Structure Click here
I1L1R5 View 3D Structure Click here
I1L4W2 View 3D Structure Click here
K7TP80 View 3D Structure Click here
K7TUS1 View 3D Structure Click here
K7U204 View 3D Structure Click here
K7VA22 View 3D Structure Click here
M0R6T8 View 3D Structure Click here
O00339 View 3D Structure Click here
O00339 View 3D Structure Click here
O01545 View 3D Structure Click here
O08746 View 3D Structure Click here
O08746 View 3D Structure Click here
O15232 View 3D Structure Click here
O35701 View 3D Structure Click here
O43405 View 3D Structure Click here
O43405 View 3D Structure Click here
O45441 View 3D Structure Click here
O45442 View 3D Structure Click here
O45443 View 3D Structure Click here
O45444 View 3D Structure Click here
O45445 View 3D Structure Click here
O62171 View 3D Structure Click here
O75578 View 3D Structure Click here
O76430 View 3D Structure Click here
O76430 View 3D Structure Click here
O76836 View 3D Structure Click here
O89029 View 3D Structure Click here
O89029 View 3D Structure Click here
O95460 View 3D Structure Click here
O95460 View 3D Structure Click here
O97267 View 3D Structure Click here
O97267 View 3D Structure Click here
O97267 View 3D Structure Click here
O97267 View 3D Structure Click here
O97267 View 3D Structure Click here
O97267 View 3D Structure Click here
P00751 View 3D Structure Click here
P04186 View 3D Structure Click here
P05555 View 3D Structure Click here
P06681 View 3D Structure Click here
P11215 View 3D Structure Click here
P12109 View 3D Structure Click here
P12109 View 3D Structure Click here
P12109 View 3D Structure Click here
P12110 View 3D Structure Click here
P12110 View 3D Structure Click here
P12110 View 3D Structure Click here
P17301 View 3D Structure Click here
P18614 View 3D Structure Click here
P19823 View 3D Structure Click here
P19827 View 3D Structure Click here
P20701 View 3D Structure Click here
P20702 View 3D Structure Click here
P21180 View 3D Structure Click here
P21941 View 3D Structure Click here
P21941 View 3D Structure Click here
P24063 View 3D Structure Click here
P34393 View 3D Structure Click here
P34393 View 3D Structure Click here
P38570 View 3D Structure Click here
P51942 View 3D Structure Click here
P51942 View 3D Structure Click here
P56199 View 3D Structure Click here
P58335 View 3D Structure Click here
P61622 View 3D Structure Click here
P76396 View 3D Structure Click here
P76481 View 3D Structure Click here
Q02788 View 3D Structure Click here
Q02788 View 3D Structure Click here
Q02788 View 3D Structure Click here
Q04857 View 3D Structure Click here
Q04857 View 3D Structure Click here
Q04857 View 3D Structure Click here
Q05707 View 3D Structure Click here
Q05707 View 3D Structure Click here
Q06033 View 3D Structure Click here
Q0DR99 View 3D Structure Click here
Q0PMD2 View 3D Structure Click here
Q0WQX9 View 3D Structure Click here
Q10RY0 View 3D Structure Click here
Q13349 View 3D Structure Click here
Q14624 View 3D Structure Click here
Q14CN2 View 3D Structure Click here
Q18048 View 3D Structure Click here
Q18048 View 3D Structure Click here
Q19853 View 3D Structure Click here
Q1LYI5 View 3D Structure Click here
Q21281 View 3D Structure Click here
Q21394 View 3D Structure Click here
Q21394 View 3D Structure Click here
Q21540 View 3D Structure Click here
Q21916 View 3D Structure Click here
Q22783 View 3D Structure Click here
Q23561 View 3D Structure Click here
Q23563 View 3D Structure Click here
Q23564 View 3D Structure Click here
Q23565 View 3D Structure Click here
Q2UY09 View 3D Structure Click here
Q2UY09 View 3D Structure Click here
Q2UY11 View 3D Structure Click here
Q2UY11 View 3D Structure Click here
Q3UW98 View 3D Structure Click here
Q3V0T4 View 3D Structure Click here
Q3V3R4 View 3D Structure Click here
Q4W528 View 3D Structure Click here
Q54ES2 View 3D Structure Click here
Q54JE1 View 3D Structure Click here
Q55DY0 View 3D Structure Click here
Q5EBC0 View 3D Structure Click here
Q5GFL6 View 3D Structure Click here
Q5GFL6 View 3D Structure Click here
Q5GFL6 View 3D Structure Click here
Q5NIW0 View 3D Structure Click here
Q5NJJ5 View 3D Structure Click here
Q5NJJ5 View 3D Structure Click here
Q5RH29 View 3D Structure Click here
Q5VU97 View 3D Structure Click here
Q5XI24 View 3D Structure Click here
Q5XI24 View 3D Structure Click here
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