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686  structures 1887  species 0  interactions 21918  sequences 681  architectures

Family: Peptidase_C1 (PF00112)

Summary: Papain family cysteine protease

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Cysteine protease". More...

Cysteine protease Edit Wikipedia article

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This is the Wikipedia entry entitled "Papain". More...

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Papain family cysteine protease Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000668

This group of proteins belong to the cysteine peptidase family C1, sub-family C1A (papain family, clan CA).

The papain family has a wide variety of activities, including broad-range (papain) and narrow-range endo-peptidases, aminopeptidases, carboxypeptidases, dipeptidyl peptidases and enzymes with both exo- and endo-peptidase activity [ PUBMED:7845226 ]. Members of the papain family are widespread, found in bacteria, archaea, fungi, and practically all protozoa, plants and mammals [ PUBMED:7845226 ], and some viruses such as baculoviruses [ PUBMED:1363350 ]. The proteins are typically lysosomal or secreted. The catalytic residues of papain are Cys-25 and His-159, other important residues being Gln-19, which helps form the 'oxyanion hole', and Asn-175, which orientates the imidazole ring of His-159. Most papain-like cysteine peptidases are irreversibly inhibited by the synthetic inhibitor E64 [ PUBMED:7044372 ]. Leupeptin is a reversible inhibitor but is also an inhibitor of chymotrypsin-like serine peptidases.

A papain-like cysteine proteinase is typically synthesised as an inactive precursor (or zymogen) with an N-terminal propeptide. Activation requires removal of the propeptide. The propeptide is required for the proper folding of the newly synthesised enzyme, maintaining the peptidase in an inactive state and stabilisation of the enzyme against denaturing at neutral to alkaline pH conditions. Amino acid residues within the pro-region mediate their membrane association, and play a role in the transport of the proenzyme to lysosomes. A propeptide can exhibit high selectivity for inhibition of the peptidase from which it originates [ PUBMED:12188906 ].

The subfamily includes the following well characterised peptidases:

  • Animal lysosomal peptidases such as cathepsins B (EC 3.4.22.1), L (EC 3.4.22.15), H (EC 3.4.22.16), S (EC 3.4.22.27), K (EC 3.4.22.38), F (EC 3.4.22.41), O (EC 3.4.22.42), V (EC 3.4.22.43) and X (a carboxypeptidase, EC 3.4.18.1).
  • Plant peptidases such as papain (EC 3.4.22.2), ficin (EC 3.4.22.3), chymopapain (EC 3.4.22.6), asclepain A (EC 3.4.22.7), actinidin (EC 3.4.22.14), glycyl endopeptidase (EC 3.4.22.25), caricain (EC 3.4.22.30), ananain (EC 3.4.22.31), stem bromelain (EC 3.4.22.32 and fruit bromelain (EC 3.4.22.33).
  • Protozoan peptidases such as histolysain (EC 3.4.22.35) and cruzipain (EC 3.4.22.51).
  • Viral peptidases such as V-cath (EC 3.4.22.50).

There are also proteins in the family that are not peptidases because one or more of the active site residues is not conserved. These include testin, tubulointerstitial nephritis antigen and silicatein.

Cysteine peptidases with a chymotrypsin-like fold are included in clan PA, which also includes serine peptidases. Cysteine peptidases that are N-terminal nucleophile hydrolases are included in clan PB. Cysteine peptidases with a tertiary structure similar to that of the serine-type aspartyl dipeptidase are included in clan PC. Cysteine peptidases with an intein-like fold are included in clan PD, which also includes asparagine lyases.

A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. Hydrolysis involves usually a catalytic triad consisting of the thiol group of the cysteine, the imidazolium ring of a histidine, and a third residue, usually asparagine or aspartic acid, to orientate and activate the imidazolium ring. In only one family of cysteine peptidases, is the role of the general base assigned to a residue other than a histidine: in peptidases from family C89 (acid ceramidase) an arginine is the general base. Cysteine peptidases can be grouped into fourteen different clans, with members of each clan possessing a tertiary fold unique to the clan. Four clans of cysteine peptidases share structural similarities with serine and threonine peptidases and asparagine lyases. From sequence similarities, cysteine peptidases can be clustered into over 80 different families [ PUBMED:11517925 ]. Clans CF, CM, CN, CO, CP and PD contain only one family.

Cysteine peptidases are often active at acidic pH and are therefore confined to acidic environments, such as the animal lysosome or plant vacuole. Cysteine peptidases can be endopeptidases, aminopeptidases, carboxypeptidases, dipeptidyl-peptidases or omega-peptidases. They are inhibited by thiol chelators such as iodoacetate, iodoacetic acid, N -ethylmaleimide or p -chloromercuribenzoate.

Clan CA includes proteins with a papain-like fold. There is a catalytic triad which occurs in the order: Cys/His/Asn (or Asp). A fourth residue, usually Gln, is important for stabilising the acyl intermediate that forms during catalysis, and this precedes the active site Cys. The fold consists of two subdomains with the active site between them. One subdomain consists of a bundle of helices, with the catalytic Cys at the end of one of them, and the other subdomain is a beta-barrel with the active site His and Asn (or Asp). There are over thirty families in the clan, and tertiary structures have been solved for members of most of these. Peptidases in clan CA are usually sensitive to the small molecule inhibitor E64, which is ineffective against peptidases from other clans of cysteine peptidases [ PUBMED:7044372 ].

Clan CD includes proteins with a caspase-like fold. Proteins in the clan have an alpha/beta/alpha sandwich structure. There is a catalytic dyad which occurs in the order His/Cys. The active site His occurs in a His-Gly motif and the active site Cys occurs in an Ala-Cys motif; both motifs are preceded by a block of hydrophobic residues [ PUBMED:9891971 ]. Specificity is predominantly directed towards residues that occupy the S1 binding pocket, so that caspases cleave aspartyl bonds, legumains cleave asparaginyl bonds, and gingipains cleave lysyl or arginyl bonds.

Clan CE includes proteins with an adenain-like fold. The fold consists of two subdomains with the active site between them. One domain is a bundle of helices, and the other a beta barrell. The subdomains are in the opposite order to those found in peptidases from clan CA, and this is reflected in the order of active site residues: His/Asn/Gln/Cys. This has prompted speculation that proteins in clans CA and CE are related, and that members of one clan are derived from a circular permutation of the structure of the other.

Clan CL includes proteins with a sortase B-like fold. Peptidases in the clan hydrolyse and transfer bacterial cell wall peptides. The fold shows a closed beta barrel decorated with helices with the active site at one end of the barrel [ PUBMED:14725770 ]. The active site consists of a His/Cys catalytic dyad.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(157)
Full
(21918)
Representative proteomes UniProt
(53065)
RP15
(5709)
RP35
(12415)
RP55
(19370)
RP75
(24632)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(157)
Full
(21918)
Representative proteomes UniProt
(53065)
RP15
(5709)
RP35
(12415)
RP55
(19370)
RP75
(24632)
Alignment:
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Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(157)
Full
(21918)
Representative proteomes UniProt
(53065)
RP15
(5709)
RP35
(12415)
RP55
(19370)
RP75
(24632)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: Cys-protease;
Type: Domain
Sequence Ontology: SO:0000417
Author: Sonnhammer ELL
Number in seed: 157
Number in full: 21918
Average length of the domain: 194.80 aa
Average identity of full alignment: 30 %
Average coverage of the sequence by the domain: 53.24 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.7 20.7
Trusted cut-off 20.7 20.7
Noise cut-off 20.6 20.6
Model length: 219
Family (HMM) version: 25
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Peptidase_C1 domain has been found. There are 686 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JX50 View 3D Structure Click here
A0A0G2KAE5 View 3D Structure Click here
A0A0G2L792 View 3D Structure Click here
A0A0N7KCX2 View 3D Structure Click here
A0A0N7KIN5 View 3D Structure Click here
A0A0N7KRA0 View 3D Structure Click here
A0A0N7KRA1 View 3D Structure Click here
A0A0P0WQJ6 View 3D Structure Click here
A0A0P0WS10 View 3D Structure Click here
A0A0P0XQB7 View 3D Structure Click here
A0A0P0XQE7 View 3D Structure Click here
A0A0P0XQH0 View 3D Structure Click here
A0A0P0XQX8 View 3D Structure Click here
A0A0P0XR37 View 3D Structure Click here
A0A0P0XRA0 View 3D Structure Click here
A0A0R0EE49 View 3D Structure Click here
A0A0R0EE49 View 3D Structure Click here
A0A0R0EQB4 View 3D Structure Click here
A0A0R0F6I9 View 3D Structure Click here
A0A0R0F8Z1 View 3D Structure Click here
A0A0R0FYJ1 View 3D Structure Click here
A0A0R0FYJ1 View 3D Structure Click here
A0A0R0G4W2 View 3D Structure Click here
A0A0R0GB30 View 3D Structure Click here
A0A0R0GFY3 View 3D Structure Click here
A0A0R0H4M2 View 3D Structure Click here
A0A0R0H4M8 View 3D Structure Click here
A0A0R0H550 View 3D Structure Click here
A0A0R0H5F5 View 3D Structure Click here
A0A0R0H5F7 View 3D Structure Click here
A0A0R0H7V8 View 3D Structure Click here
A0A0R0HDY3 View 3D Structure Click here
A0A0R0HDY3 View 3D Structure Click here
A0A0R0HE40 View 3D Structure Click here
A0A0R0HF56 View 3D Structure Click here
A0A0R0HF56 View 3D Structure Click here
A0A0R0HF84 View 3D Structure Click here
A0A0R0I0K6 View 3D Structure Click here
A0A0R0ITP6 View 3D Structure Click here
A0A0R0J4X2 View 3D Structure Click here
A0A0R0JBA3 View 3D Structure Click here
A0A0R0JH87 View 3D Structure Click here
A0A0R0JH87 View 3D Structure Click here
A0A0R0JMB1 View 3D Structure Click here
A0A0R0JSH1 View 3D Structure Click here
A0A0R0JU44 View 3D Structure Click here
A0A0R0JUA1 View 3D Structure Click here
A0A0R0JW80 View 3D Structure Click here
A0A0R0K177 View 3D Structure Click here
A0A0R0KC23 View 3D Structure Click here
A0A0R0KWV5 View 3D Structure Click here
A0A0R0KWV5 View 3D Structure Click here
A0A0R0KXW0 View 3D Structure Click here
A0A0R4IK18 View 3D Structure Click here
A0A0R4IUN6 View 3D Structure Click here
A0A0R4J5M9 View 3D Structure Click here
A0A143ZWJ1 View 3D Structure Click here
A0A144A2G5 View 3D Structure Click here
A0A144A2G5 View 3D Structure Click here
A0A1D6DW35 View 3D Structure Click here
A0A1D6EEX8 View 3D Structure Click here
A0A1D6EEY9 View 3D Structure Click here
A0A1D6EEZ9 View 3D Structure Click here
A0A1D6EM70 View 3D Structure Click here
A0A1D6EM80 View 3D Structure Click here
A0A1D6ER43 View 3D Structure Click here
A0A1D6ESI5 View 3D Structure Click here
A0A1D6EVL1 View 3D Structure Click here
A0A1D6F2H8 View 3D Structure Click here
A0A1D6F6N1 View 3D Structure Click here
A0A1D6FFM0 View 3D Structure Click here
A0A1D6FM57 View 3D Structure Click here
A0A1D6FYD0 View 3D Structure Click here
A0A1D6GGX8 View 3D Structure Click here
A0A1D6GTM2 View 3D Structure Click here
A0A1D6GUE7 View 3D Structure Click here
A0A1D6HD70 View 3D Structure Click here
A0A1D6HI75 View 3D Structure Click here
A0A1D6HI75 View 3D Structure Click here
A0A1D6I3J9 View 3D Structure Click here
A0A1D6ICV6 View 3D Structure Click here
A0A1D6IIP0 View 3D Structure Click here
A0A1D6IIP1 View 3D Structure Click here
A0A1D6IKX9 View 3D Structure Click here
A0A1D6J4A8 View 3D Structure Click here
A0A1D6JG12 View 3D Structure Click here
A0A1D6KMS9 View 3D Structure Click here
A0A1D6LPA2 View 3D Structure Click here
A0A1D6LPA3 View 3D Structure Click here
A0A1D6LWA0 View 3D Structure Click here
A0A1D6LWA2 View 3D Structure Click here
A0A1D6MEN2 View 3D Structure Click here
A0A1D6MEN3 View 3D Structure Click here
A0A1D6MHR4 View 3D Structure Click here
A0A1D6MK11 View 3D Structure Click here
A0A1D6N408 View 3D Structure Click here
A0A1D6N853 View 3D Structure Click here
A0A1D6NUP6 View 3D Structure Click here
A0A1D6NUQ6 View 3D Structure Click here
A0A1D6NUQ6 View 3D Structure Click here
A0A1D6NYF9 View 3D Structure Click here
A0A1D6NYG2 View 3D Structure Click here
A0A1D6NYG3 View 3D Structure Click here
A0A1D6PEZ3 View 3D Structure Click here
A0A1D6PSD8 View 3D Structure Click here
A0A1D6PTB9 View 3D Structure Click here
A0A1D6PTC3 View 3D Structure Click here
A0A1X7YI07 View 3D Structure Click here
A0A2R8QDZ6 View 3D Structure Click here
A1ZAU4 View 3D Structure Click here
A2BEM8 View 3D Structure Click here
A2BF64 View 3D Structure Click here
A4HTP0 View 3D Structure Click here
A4HYH2 View 3D Structure Click here
A4I4D6 View 3D Structure Click here
A5WVL6 View 3D Structure Click here
A7MCR6 View 3D Structure Click here
A8E588 View 3D Structure Click here
B4F9B5 View 3D Structure Click here
B4FS65 View 3D Structure Click here
B4FS90 View 3D Structure Click here
B4FX40 View 3D Structure Click here
B4FYA3 View 3D Structure Click here
B4FZ79 View 3D Structure Click here
B5KVP9 View 3D Structure Click here
B6TIC7 View 3D Structure Click here
B6TLC8 View 3D Structure Click here
B7ZXQ3 View 3D Structure Click here
C4IZ54 View 3D Structure Click here
C6TA48 View 3D Structure Click here
C6TDZ7 View 3D Structure Click here
C6TKC0 View 3D Structure Click here
D3ZFE5 View 3D Structure Click here
D3ZP54 View 3D Structure Click here
D3ZZ07 View 3D Structure Click here
E7F8Y7 View 3D Structure Click here
E7FA09 View 3D Structure Click here
E9Q623 View 3D Structure Click here
E9QBE2 View 3D Structure Click here
E9QE79 View 3D Structure Click here
F1Q8A0 View 3D Structure Click here
F1QCP8 View 3D Structure Click here
F1R4G6 View 3D Structure Click here
F1R7B3 View 3D Structure Click here
F1R8Y0 View 3D Structure Click here
F1R9W6 View 3D Structure Click here
F1RDQ9 View 3D Structure Click here
F1RE14 View 3D Structure Click here
F4HVZ1 View 3D Structure Click here
F4HZW2 View 3D Structure Click here
F4JNL3 View 3D Structure Click here
G3V9F8 View 3D Structure Click here
G5EGP8 View 3D Structure Click here
I1J446 View 3D Structure Click here
I1J447 View 3D Structure Click here
I1JQZ6 View 3D Structure Click here
I1JSR6 View 3D Structure Click here
I1JT65 View 3D Structure Click here
I1JT73 View 3D Structure Click here
I1JTM0 View 3D Structure Click here
I1JXE2 View 3D Structure Click here
I1K268 View 3D Structure Click here
I1K795 View 3D Structure Click here
I1K796 View 3D Structure Click here
I1KC88 View 3D Structure Click here
I1KEJ9 View 3D Structure Click here
I1KEK2 View 3D Structure Click here
I1KEK3 View 3D Structure Click here
I1KEK6 View 3D Structure Click here
I1KEL0 View 3D Structure Click here
I1KEN8 View 3D Structure Click here
I1KES2 View 3D Structure Click here
I1KES3 View 3D Structure Click here
I1KLT2 View 3D Structure Click here
I1L1Q3 View 3D Structure Click here
I1LJ95 View 3D Structure Click here
I1LL41 View 3D Structure Click here
I1LPZ4 View 3D Structure Click here
I1LR49 View 3D Structure Click here
I1LR51 View 3D Structure Click here
I1LSC0 View 3D Structure Click here
I1LSF8 View 3D Structure Click here
I1LSI6 View 3D Structure Click here
I1LSJ1 View 3D Structure Click here
I1M8Q5 View 3D Structure Click here
I1MC68 View 3D Structure Click here
I1MER7 View 3D Structure Click here
I1MHG0 View 3D Structure Click here
I1MMG2 View 3D Structure Click here
I1MUK9 View 3D Structure Click here
I1MVT7 View 3D Structure Click here
I1MXL3 View 3D Structure Click here
I1NBK8 View 3D Structure Click here
K7K0Y1 View 3D Structure Click here
K7KXR2 View 3D Structure Click here
K7KXR4 View 3D Structure Click here
K7KXR5 View 3D Structure Click here
K7KXR6 View 3D Structure Click here
K7KXR7 View 3D Structure Click here
K7KXR8 View 3D Structure Click here
K7KXR9 View 3D Structure Click here
K7KXS2 View 3D Structure Click here
K7KXU2 View 3D Structure Click here
K7KXU2 View 3D Structure Click here
K7KXU4 View 3D Structure Click here
K7KXU4 View 3D Structure Click here
K7KXU7 View 3D Structure Click here
K7KXU7 View 3D Structure Click here
K7L2V8 View 3D Structure Click here
K7LUE4 View 3D Structure Click here
K7LUF0 View 3D Structure Click here
K7LUF0 View 3D Structure Click here
K7LUG1 View 3D Structure Click here
K7LUH9 View 3D Structure Click here
K7LUI2 View 3D Structure Click here
K7LUI3 View 3D Structure Click here
K7LW54 View 3D Structure Click here
K7LW54 View 3D Structure Click here
K7M1C1 View 3D Structure Click here
K7MGB8 View 3D Structure Click here
K7MNZ5 View 3D Structure Click here
K7U1V7 View 3D Structure Click here
K7VC84 View 3D Structure Click here
K7VRR0 View 3D Structure Click here
K7W288 View 3D Structure Click here
K7W7X1 View 3D Structure Click here
M0RDV7 View 3D Structure Click here
O16288 View 3D Structure Click here
O16289 View 3D Structure Click here
O16454 View 3D Structure Click here
O17255 View 3D Structure Click here
O22961 View 3D Structure Click here
O35186 View 3D Structure Click here
O45466 View 3D Structure Click here
O45734 View 3D Structure Click here
O60911 View 3D Structure Click here
O62484 View 3D Structure Click here
O62484 View 3D Structure Click here
O64458 View 3D Structure Click here
O65493 View 3D Structure Click here
O70370 View 3D Structure Click here
O96163 View 3D Structure Click here
O96164 View 3D Structure Click here
O96165 View 3D Structure Click here
O96166 View 3D Structure Click here
O96167 View 3D Structure Click here
P00786 View 3D Structure Click here
P00787 View 3D Structure Click here
P04988 View 3D Structure Click here
P04989 View 3D Structure Click here
P06797 View 3D Structure Click here
P07154 View 3D Structure Click here
P07711 View 3D Structure Click here
P07858 View 3D Structure Click here
P09668 View 3D Structure Click here
P10605 View 3D Structure Click here
P15242 View 3D Structure Click here
P22895 View 3D Structure Click here
P25774 View 3D Structure Click here
P25776 View 3D Structure Click here
P25777 View 3D Structure Click here
P25778 View 3D Structure Click here
P25807 View 3D Structure Click here
P43234 View 3D Structure Click here
P43235 View 3D Structure Click here
P43295 View 3D Structure Click here
P43296 View 3D Structure Click here
P43297 View 3D Structure Click here
P43507 View 3D Structure Click here
P43508 View 3D Structure Click here
P43509 View 3D Structure Click here
P43510 View 3D Structure Click here
P49935 View 3D Structure Click here
P53634 View 3D Structure Click here
P54639 View 3D Structure Click here
P54639 View 3D Structure Click here
P54640 View 3D Structure Click here
P55097 View 3D Structure Click here
P56202 View 3D Structure Click here
P56203 View 3D Structure Click here
P80067 View 3D Structure Click here
P90850 View 3D Structure Click here
P91110 View 3D Structure Click here
P91991 View 3D Structure Click here
P92005 View 3D Structure Click here
P97821 View 3D Structure Click here
Q02765 View 3D Structure Click here
Q0J0J4 View 3D Structure Click here
Q0J238 View 3D Structure Click here
Q0JE83 View 3D Structure Click here
Q0WVJ5 View 3D Structure Click here
Q10716 View 3D Structure Click here
Q10717 View 3D Structure Click here
Q10MU5 View 3D Structure Click here
Q18740 View 3D Structure Click here
Q1L8W8 View 3D Structure Click here
Q1LUC6 View 3D Structure Click here
Q20950 View 3D Structure Click here
Q21810 View 3D Structure Click here
Q23030 View 3D Structure Click here
Q23894 View 3D Structure Click here
Q2AAB9 View 3D Structure Click here
Q2QU43 View 3D Structure Click here
Q2TN87 View 3D Structure Click here
Q32PZ8 View 3D Structure Click here
Q3ULP7 View 3D Structure Click here
Q43448 View 3D Structure Click here
Q499S6 View 3D Structure Click here
Q4CMU6 View 3D Structure Click here
Q4CQ35 View 3D Structure Click here
Q4CTX9 View 3D Structure Click here
Q4CV00 View 3D Structure Click here
Q4D659 View 3D Structure Click here
Q4DC63 View 3D Structure Click here
Q4DE83 View 3D Structure Click here
Q4DQB0 View 3D Structure Click here
Q4DV75 View 3D Structure Click here
Q4DW02 View 3D Structure Click here
Q4DW03 View 3D Structure Click here
Q4E0J6 View 3D Structure Click here
Q4E0J7 View 3D Structure Click here
Q4E5M4 View 3D Structure Click here
Q4QRC2 View 3D Structure Click here
Q4V894 View 3D Structure Click here
Q502A6 View 3D Structure Click here
Q54D62 View 3D Structure Click here
Q54F16 View 3D Structure Click here
Q54IS1 View 3D Structure Click here
Q54J84 View 3D Structure Click here
Q54MB6 View 3D Structure Click here
Q54ME1 View 3D Structure Click here
Q54QD9 View 3D Structure Click here
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