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239  structures 8556  species 0  interactions 83435  sequences 1007  architectures

Family: E1-E2_ATPase (PF00122)

Summary: E1-E2 ATPase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Proton ATPase". More...

Proton ATPase Edit Wikipedia article

In the field of enzymology, a proton ATPase is an enzyme that catalyzes the following chemical reaction:

ATP + H
2
O
+ H+
in ADP + phosphate + H+
out

The 3 substrates of this enzyme are ATP, H
2
O
, and H+
, whereas its 3 products are ADP, phosphate, and H+
.

Proton ATPases are divided into three groups[1] as outlined below:

P-type proton ATPase

P-type ATPases form a covalent phosphorylated (hence the symbol ’P') intermediate as part of its reaction cycle. P-type ATPases undergo major conformational changes during the catalytic cycle. P-type ATPases are not evolutionary related to V- and F-type ATPases.[1]

Plasma membrane H+-ATPase

P-type proton ATPase[2][3][4][5] (or plasma membrane H+
-ATPase
) is found in the plasma membranes of eubacteria, archaea, protozoa, fungi and plants. Here it serves as a functional equivalent to the Na+/K+ ATPase of animal cells; i.e. it energizes the plasma membrane by forming an electrochemical gradient of protons (Na+ in animal cells), that in turn drives secondary active transport processes across the membrane. The plasma membrane H+-ATPase is a P3A ATPase with a single polypeptide of 70-100 kDa.

Gastric H+/K+ ATPase

Animals have a gastric hydrogen potassium ATPase or H+/K+ ATPase that belongs to the P-type ATPase family and functions as an electroneutral proton pump. This pump is found in the plasma membrane of cells in the gastric mucosa and functions to acidify the stomach.[6] This enzyme is a P2C ATPase, characterized by having a supporting beta-subunit, and is closely related to the Na+/K+ ATPase.

V-type proton ATPase

V-type proton ATPase[7][8][9] (or V-ATPase) translocate protons into intracellular organelles other than mitochondria and chloroplasts, but in certain cell types they are also found in the plasma membrane. V-type ATPases acidify the lumen of the vacuole (hence the symbol 'V') of fungi and plants, and that of the lysosome in animal cells. Furthermore, they are found in endosomes, clathrin coated vesicles, hormone storage granules, secretory granules, Golgi vesicles and in the plasma membrane of a variety of animal cells. Like F-type ATPases, V-type ATPases are composed of multiple subunits and carry out rotary catalysis.[10] The reaction cycle involves tight binding of ATP but proceeds without formation of a covalent phosphorylated intermediate. V-type ATPases are evolutionary related to F-type ATPases.[11]

F-type proton ATPase

F-type proton ATPase[12][13] (or F-ATPase) typically operates as an ATP synthase that dissipates a proton gradient rather than generating one; i.e. protons flow in the reverse direction compared to V-type ATPases. In eubacteria, F-type ATPases are found in plasma membranes. In eukaryotes, they are found in the mitochondrial inner membranes and in chloroplast thylakoid membranes. Like V-type ATPases, F-type ATPases are composed of multiple subunits and carry out rotary catalysis. The reaction cycle involves tight binding of ATP but proceeds without formation of a covalent phosphorylated intermediate. F-type ATPases are evolutionary related to V-type ATPases.[11]

References

  1. ^ a b Pedersen PL, Carafoli E (1987). "Ion motive ATPases. I. Ubiquity, properties, and significance to cell function". Trends in Biochemical Sciences. 12: 146–50. doi:10.1016/0968-0004(87)90071-5.
  2. ^ Goffeau A, Slayman CW (December 1981). "The proton-translocating ATPase of the fungal plasma membrane". Biochimica et Biophysica Acta. 639 (3–4): 197–223. doi:10.1016/0304-4173(81)90010-0. PMID 6461354.
  3. ^ Morsomme P, Slayman CW, Goffeau A (November 2000). "Mutagenic study of the structure, function and biogenesis of the yeast plasma membrane H(+)-ATPase". Biochimica et Biophysica Acta. 1469 (3): 133–57. doi:10.1016/S0304-4157(00)00015-0. PMID 11063881.
  4. ^ Palmgren MG (June 2001). "PLANT PLASMA MEMBRANE H+-ATPases: Powerhouses for Nutrient Uptake". Annual Review of Plant Physiology and Plant Molecular Biology. 52: 817–845. doi:10.1146/annurev.arplant.52.1.817. PMID 11337417.
  5. ^ Morth JP, Pedersen BP, Buch-Pedersen MJ, Andersen JP, Vilsen B, Palmgren MG, Nissen P (January 2011). "A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps". Nature Reviews. Molecular Cell Biology. 12 (1): 60–70. doi:10.1038/nrm3031. PMID 21179061.
  6. ^ Sachs G, Shin JM, Briving C, Wallmark B, Hersey S (1995). "The pharmacology of the gastric acid pump: the H+,K+ ATPase". Annu Rev Pharmacol Toxicol. 35: 277–305. doi:10.1146/annurev.pa.35.040195.001425. PMID 7598495.
  7. ^ Beyenbach KW, Wieczorek H (February 2006). "The V-type H+ ATPase: molecular structure and function, physiological roles and regulation". The Journal of Experimental Biology. 209 (Pt 4): 577–89. doi:10.1242/jeb.02014. PMID 16449553.
  8. ^ Nelson N (November 1992). "The vacuolar H(+)-ATPase--one of the most fundamental ion pumps in nature". The Journal of Experimental Biology. 172: 19–27. PMID 1337091.
  9. ^ Marshansky V, Rubinstein JL, Grüber G (June 2014). "Eukaryotic V-ATPase: novel structural findings and functional insights". Biochimica et Biophysica Acta. 1837 (6): 857–79. doi:10.1016/j.bbabio.2014.01.018. PMID 24508215.
  10. ^ Stewart AG, Laming EM, Sobti M, Stock D (April 2014). "Rotary ATPases--dynamic molecular machines". Current Opinion in Structural Biology. 25: 40–8. doi:10.1016/j.sbi.2013.11.013. PMID 24878343.
  11. ^ a b Mulkidjanian AY, Makarova KS, Galperin MY, Koonin EV (November 2007). "Inventing the dynamo machine: the evolution of the F-type and V-type ATPases". Nature Reviews. Microbiology. 5 (11): 892–9. doi:10.1038/nrmicro1767. PMID 17938630.
  12. ^ Boyer PD (1997). "The ATP synthase--a splendid molecular machine". Annual Review of Biochemistry. 66: 717–49. doi:10.1146/annurev.biochem.66.1.717. PMID 9242922.
  13. ^ Junge W, Nelson N (2015). "ATP synthase". Annual Review of Biochemistry. 84: 631–57. doi:10.1146/annurev-biochem-060614-034124. PMID 25839341.

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

E1-E2 ATPase Provide feedback

No Pfam abstract.

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External database links

This tab holds annotation information from the InterPro database.

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Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(70)
Full
(83435)
Representative proteomes UniProt
(268050)
RP15
(11327)
RP35
(36988)
RP55
(74545)
RP75
(116805)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(70)
Full
(83435)
Representative proteomes UniProt
(268050)
RP15
(11327)
RP35
(36988)
RP55
(74545)
RP75
(116805)
Alignment:
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Order:
Sequence:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(70)
Full
(83435)
Representative proteomes UniProt
(268050)
RP15
(11327)
RP35
(36988)
RP55
(74545)
RP75
(116805)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Sonnhammer ELL , Bateman A
Number in seed: 70
Number in full: 83435
Average length of the domain: 186.10 aa
Average identity of full alignment: 23 %
Average coverage of the sequence by the domain: 20.99 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 28.1 28.1
Trusted cut-off 28.1 28.1
Noise cut-off 28.0 28.0
Model length: 181
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the E1-E2_ATPase domain has been found. There are 239 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096SBT9 View 3D Structure Click here
A0A0B4LGC2 View 3D Structure Click here
A0A0G2K3P7 View 3D Structure Click here
A0A0N7KES2 View 3D Structure Click here
A0A0P0VFR4 View 3D Structure Click here
A0A0P0VQP6 View 3D Structure Click here
A0A0P0VS26 View 3D Structure Click here
A0A0P0VTT2 View 3D Structure Click here
A0A0P0VX09 View 3D Structure Click here
A0A0P0W3I8 View 3D Structure Click here
A0A0P0X004 View 3D Structure Click here
A0A0P0Y1P2 View 3D Structure Click here
A0A0P0Y2E1 View 3D Structure Click here
A0A0R0FIK0 View 3D Structure Click here
A0A0R0FZY9 View 3D Structure Click here
A0A0R0G1Y0 View 3D Structure Click here
A0A0R0H670 View 3D Structure Click here
A0A0R0H8K5 View 3D Structure Click here
A0A0R0I422 View 3D Structure Click here
A0A0R0IAH0 View 3D Structure Click here
A0A0R0IMZ6 View 3D Structure Click here
A0A0R0IZT6 View 3D Structure Click here
A0A0R0J2X3 View 3D Structure Click here
A0A0R0JX32 View 3D Structure Click here
A0A0R0JZ81 View 3D Structure Click here
A0A0R0K0B7 View 3D Structure Click here
A0A0R0K4C4 View 3D Structure Click here
A0A0R0KP42 View 3D Structure Click here
A0A0R0KQ68 View 3D Structure Click here
A0A0R0KRJ2 View 3D Structure Click here
A0A0R0LL96 View 3D Structure Click here
A0A0R4IJ10 View 3D Structure Click here
A0A0R4IQS8 View 3D Structure Click here
A0A143ZZK9 View 3D Structure Click here
A0A1D6DVK9 View 3D Structure Click here
A0A1D6E3L5 View 3D Structure Click here
A0A1D6E3M8 View 3D Structure Click here
A0A1D6EKZ4 View 3D Structure Click here
A0A1D6EL09 View 3D Structure Click here
A0A1D6FQH9 View 3D Structure Click here
A0A1D6G139 View 3D Structure Click here
A0A1D6G4Q8 View 3D Structure Click here
A0A1D6GQJ5 View 3D Structure Click here
A0A1D6GQV3 View 3D Structure Click here
A0A1D6GU98 View 3D Structure Click here
A0A1D6GUZ6 View 3D Structure Click here
A0A1D6H246 View 3D Structure Click here
A0A1D6H478 View 3D Structure Click here
A0A1D6HUV1 View 3D Structure Click here
A0A1D6I7L2 View 3D Structure Click here
A0A1D6II73 View 3D Structure Click here
A0A1D6IQZ9 View 3D Structure Click here
A0A1D6JDM1 View 3D Structure Click here
A0A1D6JGC8 View 3D Structure Click here
A0A1D6JJK6 View 3D Structure Click here
A0A1D6JKC9 View 3D Structure Click here
A0A1D6JMJ0 View 3D Structure Click here
A0A1D6JQ62 View 3D Structure Click here
A0A1D6JQD0 View 3D Structure Click here
A0A1D6JRX7 View 3D Structure Click here
A0A1D6JYK5 View 3D Structure Click here
A0A1D6K197 View 3D Structure Click here
A0A1D6KEU3 View 3D Structure Click here
A0A1D6KIE0 View 3D Structure Click here
A0A1D6KJJ2 View 3D Structure Click here
A0A1D6KVF4 View 3D Structure Click here
A0A1D6KXS4 View 3D Structure Click here
A0A1D6KZT2 View 3D Structure Click here
A0A1D6L337 View 3D Structure Click here
A0A1D6M3W3 View 3D Structure Click here
A0A1D6M7B4 View 3D Structure Click here
A0A1D6MV33 View 3D Structure Click here
A0A1D6N1X0 View 3D Structure Click here
A0A1D6NG99 View 3D Structure Click here
A0A1D6NTT8 View 3D Structure Click here
A0A1D6P5L7 View 3D Structure Click here
A0A1D6P5L7 View 3D Structure Click here
A0A1D6PAY7 View 3D Structure Click here
A0A1D6QC18 View 3D Structure Click here
A0A1D6QC18 View 3D Structure Click here
A0A1D6QHD5 View 3D Structure Click here
A0A1D6QK34 View 3D Structure Click here
A0A1D8PDD2 View 3D Structure Click here
A0A1D8PEI4 View 3D Structure Click here
A0A1D8PGL4 View 3D Structure Click here
A0A1D8PJ01 View 3D Structure Click here
A0A1D8PLQ7 View 3D Structure Click here
A0A1D8PQK6 View 3D Structure Click here
A0A286Y8A8 View 3D Structure Click here
A0A286Y8X6 View 3D Structure Click here
A0A286Y8X6 View 3D Structure Click here
A0A2R8Q705 View 3D Structure Click here
A0A2R8Q983 View 3D Structure Click here
A0A2R8QFL1 View 3D Structure Click here
A0A2R8QFP5 View 3D Structure Click here
A0A2R8QJH4 View 3D Structure Click here
A0A2R8QKM0 View 3D Structure Click here
A0A2R8QLX3 View 3D Structure Click here
A0A2R8QLX3 View 3D Structure Click here
A0A2R8QNN7 View 3D Structure Click here
A0A2R8RK22 View 3D Structure Click here
A0A368UHC2 View 3D Structure Click here
A0A368UHW8 View 3D Structure Click here
A0A381MFJ0 View 3D Structure Click here
A3AWA4 View 3D Structure Click here
A3BF39 View 3D Structure Click here
A3FIN4 View 3D Structure Click here
A4HRZ6 View 3D Structure Click here
A4HSA9 View 3D Structure Click here
A4HT82 View 3D Structure Click here
A4HTD0 View 3D Structure Click here
A4HTF0 View 3D Structure Click here
A4HVT2 View 3D Structure Click here
A4HXD4 View 3D Structure Click here
A4HY21 View 3D Structure Click here
A4HY23 View 3D Structure Click here
A4I8W5 View 3D Structure Click here
A4I980 View 3D Structure Click here
A4IA89 View 3D Structure Click here
A4IBA6 View 3D Structure Click here
A7L9Z8 View 3D Structure Click here
A8DZ26 View 3D Structure Click here
A8QI34 View 3D Structure Click here
A9C3Q4 View 3D Structure Click here
B0S5H3 View 3D Structure Click here
B0S5H3 View 3D Structure Click here
B0S5Q5 View 3D Structure Click here
B3DFZ2 View 3D Structure Click here
B8JKS7 View 3D Structure Click here
B8JKS9 View 3D Structure Click here
B8JKT0 View 3D Structure Click here
B9DFX7 View 3D Structure Click here
C4J1E7 View 3D Structure Click here
D3ZFC5 View 3D Structure Click here
D4A3X6 View 3D Structure Click here
D4A509 View 3D Structure Click here
D4A7K5 View 3D Structure Click here
D4AA47 View 3D Structure Click here
D4ABB8 View 3D Structure Click here
E7FFK0 View 3D Structure Click here
E9AG74 View 3D Structure Click here
F1M9L4 View 3D Structure Click here
F1MA70 View 3D Structure Click here
F1MAA4 View 3D Structure Click here
F1Q4S1 View 3D Structure Click here
F1Q5B3 View 3D Structure Click here
F1Q7N8 View 3D Structure Click here
F1QBG4 View 3D Structure Click here
F1QBG4 View 3D Structure Click here
F1R1X4 View 3D Structure Click here
F1RC03 View 3D Structure Click here
F1RC03 View 3D Structure Click here
F1REW4 View 3D Structure Click here
F4KHQ2 View 3D Structure Click here
F6PDY7 View 3D Structure Click here
F6PDY7 View 3D Structure Click here
F8W2B0 View 3D Structure Click here
G3V7I3 View 3D Structure Click here
G5E829 View 3D Structure Click here
G5E829 View 3D Structure Click here
G5EBE7 View 3D Structure Click here
G5EBH1 View 3D Structure Click here
G5EDU1 View 3D Structure Click here
G5EE14 View 3D Structure Click here
G5EEK8 View 3D Structure Click here
G5EFR6 View 3D Structure Click here
G5EFR6 View 3D Structure Click here
G5EFV6 View 3D Structure Click here
G8GVE0 View 3D Structure Click here
I1J9E1 View 3D Structure Click here
I1JA65 View 3D Structure Click here
I1JGA0 View 3D Structure Click here
I1JM65 View 3D Structure Click here
I1JNA7 View 3D Structure Click here
I1JPG1 View 3D Structure Click here
I1JTQ7 View 3D Structure Click here
I1JUM2 View 3D Structure Click here
I1JWZ3 View 3D Structure Click here
I1JXU9 View 3D Structure Click here
I1JZT5 View 3D Structure Click here
I1K1G8 View 3D Structure Click here
I1K2D4 View 3D Structure Click here
I1K370 View 3D Structure Click here
I1K861 View 3D Structure Click here
I1K8G7 View 3D Structure Click here
I1K937 View 3D Structure Click here
I1KBT2 View 3D Structure Click here
I1KCP1 View 3D Structure Click here
I1KD58 View 3D Structure Click here
I1KGW2 View 3D Structure Click here
I1KR29 View 3D Structure Click here
I1KRI8 View 3D Structure Click here
I1KVJ0 View 3D Structure Click here
I1KVR4 View 3D Structure Click here
I1KXN1 View 3D Structure Click here
I1L5J0 View 3D Structure Click here
I1L6Z6 View 3D Structure Click here
I1LA34 View 3D Structure Click here
I1LH66 View 3D Structure Click here
I1LIT6 View 3D Structure Click here
I1LUH9 View 3D Structure Click here
I1LVP7 View 3D Structure Click here
I1LWI1 View 3D Structure Click here
I1LZM3 View 3D Structure Click here
I1M5Y0 View 3D Structure Click here
I1M6A4 View 3D Structure Click here
I1M9S1 View 3D Structure Click here
I1MC84 View 3D Structure Click here
I1MCB8 View 3D Structure Click here
I1MGV5 View 3D Structure Click here
I1MGZ2 View 3D Structure Click here
I1MI27 View 3D Structure Click here
I1MKG4 View 3D Structure Click here
I1MSP4 View 3D Structure Click here
I1MTP0 View 3D Structure Click here
I1MTX6 View 3D Structure Click here
I1MVM0 View 3D Structure Click here
I1MWG2 View 3D Structure Click here
I1N1N9 View 3D Structure Click here
I1N5P8 View 3D Structure Click here
I1N6I6 View 3D Structure Click here
I1N912 View 3D Structure Click here
I1N9K8 View 3D Structure Click here
I1NA25 View 3D Structure Click here
I3ITM6 View 3D Structure Click here
K7KI34 View 3D Structure Click here
K7L4D4 View 3D Structure Click here
K7L6G0 View 3D Structure Click here
K7L889 View 3D Structure Click here
K7LC34 View 3D Structure Click here
K7LMP8 View 3D Structure Click here
K7LWS4 View 3D Structure Click here
K7LWU0 View 3D Structure Click here
K7MCV9 View 3D Structure Click here
K7MJ28 View 3D Structure Click here
K7MK57 View 3D Structure Click here
K7MM17 View 3D Structure Click here
K7MTT9 View 3D Structure Click here
K7MW11 View 3D Structure Click here
K7MY99 View 3D Structure Click here
K7U845 View 3D Structure Click here
K7UUB3 View 3D Structure Click here
K7VI72 View 3D Structure Click here
K7VJC3 View 3D Structure Click here
M0R6E0 View 3D Structure Click here
M9PG15 View 3D Structure Click here
O14022 View 3D Structure Click here
O14072 View 3D Structure Click here
O14983 View 3D Structure Click here
O16331 View 3D Structure Click here
O16436 View 3D Structure Click here
O22218 View 3D Structure Click here
O23087 View 3D Structure Click here
O43520 View 3D Structure Click here
O43861 View 3D Structure Click here
O55143 View 3D Structure Click here
O59666 View 3D Structure Click here
O59868 View 3D Structure Click here
O60423 View 3D Structure Click here
O64474 View 3D Structure Click here
O64806 View 3D Structure Click here
O70228 View 3D Structure Click here
O74431 View 3D Structure Click here
O75110 View 3D Structure Click here
O75185 View 3D Structure Click here
O81108 View 3D Structure Click here
P03960 View 3D Structure Click here
P05023 View 3D Structure Click here
P05030 View 3D Structure Click here
P06685 View 3D Structure Click here
P06686 View 3D Structure Click here
P06687 View 3D Structure Click here
P09626 View 3D Structure Click here
P09627 View 3D Structure Click here
P0ABB8 View 3D Structure Click here
P0CW77 View 3D Structure Click here
P11505 View 3D Structure Click here
P11505 View 3D Structure Click here
P11506 View 3D Structure Click here
P11506 View 3D Structure Click here
P11507 View 3D Structure Click here
P13586 View 3D Structure Click here
P13587 View 3D Structure Click here
P13607 View 3D Structure Click here
P13637 View 3D Structure Click here
P15718 View 3D Structure Click here
P16615 View 3D Structure Click here
P18596 View 3D Structure Click here
P19456 View 3D Structure Click here
P19657 View 3D Structure Click here
P20020 View 3D Structure Click here
P20020 View 3D Structure Click here
P20431 View 3D Structure Click here
P20648 View 3D Structure Click here
P20649 View 3D Structure Click here
P22189 View 3D Structure Click here
P22189 View 3D Structure Click here
P22700 View 3D Structure Click here
P23634 View 3D Structure Click here
P23634 View 3D Structure Click here
P28876 View 3D Structure Click here
P35670 View 3D Structure Click here
P37617 View 3D Structure Click here
P38360 View 3D Structure Click here
P38929 View 3D Structure Click here
P38995 View 3D Structure Click here
P39986 View 3D Structure Click here
P40527 View 3D Structure Click here
P50993 View 3D Structure Click here
P54678 View 3D Structure Click here
P54679 View 3D Structure Click here
P54707 View 3D Structure Click here
P54708 View 3D Structure Click here
P57792 View 3D Structure Click here
P70704 View 3D Structure Click here
P70705 View 3D Structure Click here
P90735 View 3D Structure Click here
P90747 View 3D Structure Click here
P91203 View 3D Structure Click here
P92939 View 3D Structure Click here
P96271 View 3D Structure Click here
P98194 View 3D Structure Click here
P98195 View 3D Structure Click here
P98196 View 3D Structure Click here
P98197 View 3D Structure Click here
P98199 View 3D Structure Click here
P98200 View 3D Structure Click here
P98205 View 3D Structure Click here
P9WPS3 View 3D Structure Click here
P9WPS5 View 3D Structure Click here
P9WPS7 View 3D Structure Click here
P9WPS9 View 3D Structure Click here
P9WPT1 View 3D Structure Click here
P9WPT3 View 3D Structure Click here
P9WPT5 View 3D Structure Click here
P9WPT7 View 3D Structure Click here
P9WPT9 View 3D Structure Click here
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